22 research outputs found
Cumulative, additive benefits of memantine-donepezil combination over component monotherapies in moderate to severe Alzheimer’s dementia: a pooled area under the curve analysis
Advances in the therapy of Alzheimer's disease: Targeting amyloid beta and tau and perspectives for the future
Worldwide multidisciplinary translational research has led to a growing knowledge of the genetics and molecular pathogenesis of Alzheimer's disease (AD) indicating that pathophysiological brain alterations occur decades before clinical signs and symptoms of cognitive decline can be diagnosed. Consequently, therapeutic concepts and targets have been increasingly focused on early-stage illness before the onset of dementia; and distinct classes of compounds are now being tested in clinical trials. At present, there is a growing consensus that therapeutic progress in AD delaying disease progression would significantly decrease the expanding global burden. The evolving hypothesis- and evidence-based generation of new diagnostic research criteria for early-stage AD has positively impacted the development of clinical trial designs and the characterization of earlier and more specific target populations for trials in prodromal as well as in pre- and asymptomatic at-risk stages of AD
Diffusion imaging changes in grey matter in Alzheimer’s disease: a potential marker of early neurodegeneration
Reflections on the Future of Pharmaceutical Public-Private Partnerships: From Input to Impact
US, EU, and Japanese Regulatory Guidelines for Development of Drugs for Treatment of Alzheimer’s Disease: Implications for Global Drug Development
The Roles of Inflammation and Immune Mechanisms in Alzheimer's Disease
The Alzheimer's Association’s Research Roundtable met in April 2015 to explore the role of immune and inflammatory mechanisms in the progression of Alzheimer’s disease (AD). The ability of innate immune cells, such as microglia and astrocytes, to mediate neuroinflammation in AD has been implicated as a contributor to disease pathogenesis. Adaptive immunity also plays a role in responding to disease or injury in the central nervous system (CNS), while innate immunity appears to drive neuroinflammation. An increased understanding of these processes may lead to new therapeutic targets, animal models and biomarkers for AD. The barriers and challenges toward new treatments will be discussed