Effect of concentrated growth factor (CGF) on short-term clinical outcomes after partially impacted mandibular third molar surgery: A split-mouth randomized clinical study

isik, gozde/0000-0001-9572-3049; , meltem/0000-0002-7088-9701WOS: 000531647300004PubMed: 31299343Purpose: the aim of this study was to evaluate the effectiveness of concentrated growth factor(CGF) on soft tissue healing and postoperative side effects following third molar surgery. Methods: This study was designed on 60 patients as a randomized single-blind clinical trial. the predictor variable was the implementation of CGF fibrin matrix, which was categorized as CGF and non-CGF. the primary outcome variable of the study was the healing of soft tissue around the extraction socket. the secondary outcome variables were pain, swelling and trismus. Data were analyzed using the non-parametric Brunner and Langer model. Statistical significance was set at P < .001. Results: Sixty patients (39 female, 21 male; mean age 25.82) with impacted mandibular third molars participated in the study. Statistical analysis revealed that there were significant differences between the control and test groups with regard to soft tissue healing, postoperative pain, swelling, and trismus (P < 0.001). Conclusion: the application of CGF accelerates soft tissue healing and is beneficial in minimising postoperative side effects, particularly pain, swelling and trismus, after extraction of mandibular third molars. (C) 2019 Published by Elsevier Masson SAS

The role of concentrated growth factor on implant stability: A preliminary study

, meltem/0000-0002-7088-9701WOS: 000572692400009PubMed: 31476535Purpose: the purpose of this preliminary study was to evaluate the effect of concentrated growth factor (CGF) on dental implant stability in type 2 bone using the resonance frequency analysis (RFA) device Smartpeg (R). Methods: the researchers carried out a prospective cohort study on a sample group composed of 12 patients (mean age = 67) who required dental implants. Implant socket preparation (with and without CGF) was the primary predictor variable. in each patient, two dental implants were inserted in the anterior mandible. For the test group, one dental implant socket was covered with CGF membrane, while the other socket was prepared conventionally for the control group. Implant stability, as measured by RFA, was the outcome variable. Measurements were taken using the Ostell device at the time of implant placement and at the 1st, 2nd and 4th weeks. Results: Mean implant stability quotients (ISQs) were 67.00 +/- 4.573 for the study group and 64.75 +/- 5.065 for the control group. the difference between the two groups was not statistically significant. Conclusion: It was found that CGF did not provide beneficial effect on dental implant stability in the early healing period in type 2 bone. (C) 2019 Elsevier Masson SAS. All rights reserved