The Focal plane Detector Package on the TUNL Split-pole Spectrograph

A focal plane detector for the Enge Split-pole Spectrograph at Triangle Universities Nuclear Laboratory has been designed. The detector package consists of two position sensitive gas avalanche counters, a gas proportionality energy loss section, and a residual energy scintillator. This setup allows both particle identification and focal plane reconstruction. In this paper we will detail the construction of each section along with their accompanying electronics and data acquisition. Effects of energy loss throughout the detector, ray tracing procedures, and resolution as a function of fill pressure and bias voltage are also investigated. A measurement of the $^{27}\!$Al$(d,p)$ reaction is used to demonstrate detector performance and to illustrate a Bayesian method of energy calibration

Talking culture? Egalitarianism, color-blindness and racism in Australian elementary schools

This study examines egalitarianism as an ethnic-racial socialization message used by teachers with 8-12 year old children in four socio-demographically diverse elementary schools in Melbourne, Australia. The three main types of egalitarian messages identified are i) procedural-justice color-blindness, ii) distributive-justice color-blindness and iii) colormuteness, and each is explored in relation to how teachers talk to children about racial, ethnic and cultural diversity, and racism. We conclude that teacher confidence and capability, and to a lesser degree, school context, influenced the types of egalitarian messages used about diversity and the extent to which teachers had explicit and critical discussions about racism

Appendix – Supplemental material for From the FEC to the Ballot Box: Voter Accountability for Campaign Finance Law Violations

<p>Supplemental material, Appendix for From the FEC to the Ballot Box: Voter Accountability for Campaign Finance Law Violations by Ben Gaskins, Ellen Seljan, Todd Lochner, Katie Kowal, Zane Dundon and Maya Gold in American Politics Research</p

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

Neurotoxic amyloid β peptide (Aβ) accumulates in the brains of individuals with Alzheimer disease (AD). The APOE4 allele is a major risk factor for sporadic AD and has been associated with increased brain parenchymal and vascular amyloid burden. How apoE isoforms influence Aβ accumulation in the brain has, however, remained unclear. Here, we have shown that apoE disrupts Aβ clearance across the mouse blood-brain barrier (BBB) in an isoform-specific manner (specifically, apoE4 had a greater disruptive effect than either apoE3 or apoE2). Aβ binding to apoE4 redirected the rapid clearance of free Aβ40/42 from the LDL receptor–related protein 1 (LRP1) to the VLDL receptor (VLDLR), which internalized apoE4 and Aβ-apoE4 complexes at the BBB more slowly than LRP1. In contrast, apoE2 and apoE3 as well as Aβ-apoE2 and Aβ-apoE3 complexes were cleared at the BBB via both VLDLR and LRP1 at a substantially faster rate than Aβ-apoE4 complexes. Astrocyte-secreted lipo-apoE2, lipo-apoE3, and lipo-apoE4 as well as their complexes with Aβ were cleared at the BBB by mechanisms similar to those of their respective lipid-poor isoforms but at 2- to 3-fold slower rates. Thus, apoE isoforms differentially regulate Aβ clearance from the brain, and this might contribute to the effects of APOE genotype on the disease process in both individuals with AD and animal models of AD

Nonstationary weather and water extremes: a review of methods for their detection, attribution, and management

Hydroclimatic extremes such as intense rainfall, floods, droughts, heatwaves, and wind/storms have devastating effects each year. One of the key challenges for society is understanding how these extremes are evolving and likely to unfold beyond their historical distributions under the influence of multiple drivers such as changes in climate, land cover, and other human factors. Methods for analysing hydroclimatic extremes have advanced considerably in recent decades. Here we provide a review of the drivers, metrics and methods for the detection, attribution, management and projection of nonstationary hydroclimatic extremes. We discuss issues and uncertainty associated with these approaches (e.g arising from insufficient record length, spurious nonstationarities, or incomplete representation of nonstationary sources in modelling frameworks), examine empirical and simulation-based frameworks for analysis of nonstationary extremes, and identify gaps for future research