22 research outputs found

    When a crisis hits: be resilient and a catalyst for positive change

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    When facing a crisis, leaders need to take a thoughtful, positive, resilient, and transformative approach to crisis management. However, they often do the opposite, denying and minimising the problem, or reactively taking action that escalates the situation. Sarah Kovoor-Misra describes four key capabilities that can help organisations not only prevent or quickly contain damage, but strengthen trust, gain new insights, and emerge with capacities that can help them cope more effectively with future crises and challenges

    Management Training Needs Assessment United Methodist Community Centers

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    This report outlines a management training plan for the United Methodist Community Centers, Inc. (UMCC). UMCC is a community service agency which focuses on bringing positive change for minorities and other disadvantaged people in the Omaha community. UMCC is one of Omaha\u27s major community service agencies and has two locations, the Wesley House in north Omaha and the Woodson Center in south Omaha. A broad range of community programs are coordinated and managed from these two centers, including, for example: family enhancement programs, a woman\u27s resource center, sweat equity housing development, senior meals programs, pre-school and after-school learning programs, and a variety of other youth activities

    Atrial arrhythmogenicity in aged Scn5a+/∆KPQ mice modeling long QT type 3 syndrome and its relationship to Na+ channel expression and cardiac conduction

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    Recent studies have reported that human mutations in Nav1.5 predispose to early age onset atrial arrhythmia. The present experiments accordingly assess atrial arrhythmogenicity in aging Scn5a+/∆KPQ mice modeling long QT3 syndrome in relationship to cardiac Na+ channel, Nav1.5, expression. Atrial electrophysiological properties in isolated Langendorff-perfused hearts from 3- and 12-month-old wild type (WT), and Scn5a+/∆KPQ mice were assessed using programmed electrical stimulation and their Nav1.5 expression assessed by Western blot. Cardiac conduction properties were assessed electrocardiographically in intact anesthetized animals. Monophasic action potential recordings demonstrated increased atrial arrhythmogenicity specifically in aged Scn5a+/ΔKPQ hearts. These showed greater action potential duration/refractory period ratios but lower atrial Nav1.5 expression levels than aged WT mice. Atrial Nav1.5 levels were higher in young Scn5a+/ΔKPQ than young WT. These levels increased with age in WT but not Scn5a+/ΔKPQ. Both young and aged Scn5a+/ΔKPQ mice showed lower heart rates and longer PR intervals than their WT counterparts. Young Scn5a+/ΔKPQ mice showed longer QT and QTc intervals than young WT. Aged Scn5a+/ΔKPQ showed longer QRS durations than aged WT. PR intervals were prolonged and QT intervals were shortened in young relative to aged WT. In contrast, ECG parameters were similar between young and aged Scn5a+/ΔKPQ. Aged murine Scn5a+/ΔKPQ hearts thus exhibit an increased atrial arrhythmogenicity. The differing Nav1.5 expression and electrocardiographic indicators of slowed cardiac conduction between Scn5a+/ΔKPQ and WT, which show further variations associated with aging, may contribute toward atrial arrhythmia in aged Scn5a+/ΔKPQ hearts
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