The survival rate survey of the patients undergoing liver transplants

Introduction: Liver transplantation is a widely distinguished and highly practical therapy for liver cirrhosis. In any case, liver transplant surgery assumes a risk of influential complications. In this way, the survival rate of liver transplant patients at Razi Healing Center in Rasht from 2017 to 2022 was investigated. Materials and Methods: In this retrospective cohort study, liver transplant patients referred to Razi Hospital in Rasht, Iran, from 2017 to 2022 were studied. Patient demographic and clinical information were collected. Survival was determined using Kaplan-Meier estimates. Log rank was used to determine differences between study groups in survival. Results: Out of 46 patients who underwent liver transplantation surgery, 54.3% of patients survived. Also, the most common causes of death for the samples of this study were COVID-19 and hemorrhage. Patients with autoimmune cirrhosis due to hepatitis have a significantly higher risk of death than those with cirrhosis due to other factors. Postoperative vascular thrombosis was found to be significantly associated with reduced patient survival. Patient outcomes improved significantly in the second part of the six-year liver transplant study. The study highlights the importance of increasing experience in liver transplant surgery and postoperative care to improve outcomes. Conclusion: According to the results of this study, patients with autoimmune cirrhosis due to hepatitis have a higher risk of death than those with cirrhosis due to other causes. In addition, postoperative vascular thrombosis is believed to significantly reduce patient survival. The study highlights the importance of increasing experience in liver transplant surgery and postoperative care to improve outcomes for these patients

Relationship between KRAS and NRAS factors with clinicopathologic findings in patients with metastatic colon cancer

Introduction: Colorectal cancer (CRC) is the third common cancer among human and the fourth common reason of mortalities caused by cancers around the world. During recent years, EGFR-related molecular pathways are known as an important therapeutic pathway. High frequency of mutations of RAS family such as KRAS and NRAS and their rapid incidence in colon cancer indicates their high potential as a biomarker for early detection. Materials and Methods: In this cross sectional retrograde study, patients with colorectal cancer referring to Golestan Razi and Poursina Hospitals in Iran were evaluated during years 2009-2018. The rates of KRAS and NRAS factors were evaluated on paraffinized pathology samples of patients with metastatic colon cancer. Then, the correlation between mutation in these two factors with other clinicopathological findings of patients such as age, gender, tumor grade, location of primary lesion, time to progression (TTP), family history and presence or absence of lymphovascular invasion was investigated. Results: There was no significant correlation observed between occurrence of NRAS and KRAS with age group, family history and gender in the present study. But there was a significant statistical correlation between the rate of NRAS gene incidence with location of primary lesion and tumor grade. Finally, there was found a significant correlation between both KRAS and NRAS genes with TTP, so that TTP of patients reported less than patients without mutations in both groups. Conclusion: The present study showed that presence of both mutations in KRAS and NRAS makes the prognosis of disease worth such a way the location of primary lesion and tumor grade are two effective factors in incidence of NRAS gene and lymphovascular invasion is the effective factor on KRAS gene incidence. also, TTP is lower among patients with mutations in both KRAS and NRAS genes