Severe hemolytic anemia associated with mild pneumonia caused by Mycoplasma pneumonia

We report a case of M. pneumoniae infection presenting with severe hemolytic anemia in a 4-year-old girl, with a ten-day history of paleness, weakness, and nonproductive cough. She was very pale and tachycardic. However, she was not tachypneic. Chest examination showed normal breath sounds. No rhoncus or whistling was heard. As the erythrocyte sedimentation rate was excessively elevated, the differential diagnosis primarily comprised hematological malignancies. Direct Coombs' test was positive. Diagnosis of M. pneumoniae infection was confirmed by elevated levels of M. pneumoniae IgG and IgM antibodies and a chest X-ray suggestive of atypical pneumonia. The patient was treated with clarithromycin and packed red cell transfusion and showed a favorable recovery within ten days after admission. In conclusion, this case demonstrates that severe hemolytic anemia caused by M. pneumoniae is not always associated with severe pulmonary involvement, even when the respiratory infection is very mild, M. pneumoniae may be the cause of severe anemia. © 2012 Zafer Kurugol et al

Serum immunoglobulin (IgG, IgM, IgA) and IgG subclass concentrations in healthy children: a study using nephelometric technique

WOS: 000236123400004PubMed ID: 16562781Immunoglobulin (Ig) G, IgM, IgA and IgG subclass (IgG1, IgG2, IgG3, IgG4) concentrations were determined in more than 500 healthy Turkish children using nephelometric technique. These parameters were thought to be highly varied for different ethnic groups because of environmental and genetic factors. Methodology used in previous studies has been reported to affect age-related normal values. Serum IgG, IgM, IgA and IgG1, IgG2, IgG3, IgG4 levels were measured in 510, 491, 486, 542, 511, 515, and 545 healthy children, respectively. According to their age, the patients were divided into 14 groups. In contrast to most of the previous studies, age-related normal values for IgG4 levels were also obtained. In conclusion, it has been suggested that our study as an example for Caucasians using nephelometric technique will supply useful information about age-related normal serum immunoglobulin and IgG subclass concentrations

Seroprevalence of hepatitis a infection in the Turkish Republic of Northern Cyprus

This study was conducted to determine the seroprevalence of hepatitis A virus (HAV) infection in the Turkish Republic of Northern Cyprus. Materials and Methods: A total of 660 unvaccinated persons 1 to 30 years old were selected for the study with cluster sampling. Information on sociodemographic characteristics was gathered for each participant and, in 641 of them, anti-HAV antibodies were assayed using an enzyme immune assay. Results: Anti-HAV prevalence in the Turkish population under the age of 30 in Northern Cyprus was 23.9%. For the age groups 1-5, 6-10 and 11-15 years, seroprevalence rates were relatively low (11.4, 9.4 and 12%, respectively). For age groups 16 years and over, HAV seroprevalence gradually increased with age, rising to 30.4% in 16 to 20 years and to 52.5% in 21 to 30 years of age. In addition to age, other variables significantly associated with HAV seroprevalence included low family income, family size, waste water sewage, and the education level of parents. Conclusions: Anti-HAV seroprevalence in the Turkish Republic of Northern Cyprus shows an intermediate prevalence. As well as expanding health education and improving sanitation, a hepatitis A universal mass vaccination program would be logical for the population. © TÜBITAK

Pemphigus vulgaris in childhood. A case report

PubMed ID: 18487981An 11-year-old girl with vesicles and eroded lesions on her oral mucosa and tongue was diagnosed as having pemphigus vulgaris. The diagnosis was confirmed by histopathologic and immunofluorescence studies. The patient was succesfully treated with methylprednisolone and azathioprine. After two months maintenance therapy was started. She is still taking methylprednisolone and azathioprine as maintenance therapy and no recurrence has been observed

Two cases of Guillain-Barré syndrome during measles elimination campaign in Izmir

PubMed ID: 18971907The authors report two cases of Guillain-Barré Syndrome (GBS) occurred during a national measles vaccination campaign in Izmir, Turkey. Among more than 325 000 vaccine recipients, only 2 cases of GBS were observed within the 10-week risk period. These cases yielded an incidence of 0.615 per 100 000 vaccine doses. The authors think that association between measles vaccination and GBS is coincidental, rather than causal. However, an epidemiological evaluation in Turkey is needed to clearly show that there is no causal association between measles vaccination and GBS