Millimeter Interferometric HCN(1-0) and HCO+(1-0) Observations of Luminous Infrared Galaxies

We present the results on millimeter interferometric observations of four luminous infrared galaxies (LIRGs), Arp 220, Mrk 231, IRAS 08572+3915, and VV 114, and one Wolf-Rayet galaxy, He 2-10, using the Nobeyama Millimeter Array (NMA). Both the HCN(1-0) and HCO+(1-0) molecular lines were observed simultaneously and their brightness-temperature ratios were derived. High-quality infrared L-band (2.8-4.1 micron) spectra were also obtained for the four LIRGs to better constrain their energy sources deeply buried in dust and molecular gas. When combined with other LIRGs we have previously observed with NMA, the final sample comprised nine LIRGs (12 LIRGs' nuclei) with available interferometric HCN(1-0) and HCO+(1-0) data-sufficient to investigate the overall trend in comparison with known AGNs and starburst galaxies. We found that LIRGs with luminous buried AGN signatures at other wavelengths tend to show high HCN(1-0)/HCO+(1-0) brightness-temperature ratios as seen in AGN-dominated galaxies, while the Wolf-Rayet galaxy He 2-10 displays a small ratio. An enhanced HCN abundance in the interstellar gas surrounding a strongly X-ray-emitting AGN, as predicted by some chemical calculations, is a natural explanation of our results.Comment: 43 pages, 11 figures, accepted for publication in Astronomical Journal. Higher resolution version is available at http://optik2.mtk.nao.ac.jp/~imanishi/Paper/HCN2/HCN2.pd

First Detection of 12CO (1--0) Emission from Two Narrow-Line Seyfert 1 Galaxies

In order to investigate how the growth of galactic bulges progresses with the growth of central black holes (BHs), we observed molecular gas (fuel for the coming star formation) in possibly young active galaxies, narrow-line Seyfert 1 galaxies (NLS1s). We present the results of radio observations of 12CO(1--0) using the Nobeyama Millimeter Array (with 2--4 kpc spatial resolution) for two FIR-bright NLS1s, yielding the first detection of their CO emission. Corresponding molecular--gas masses M(H2) of (1-3) X 109 Msun are the 2nd and 4th largest ones among NLS1s. By estimating dynamical masses and bulge masses M(bulge) for these two NLS1s using CO channel map and CO line widths, we found M(H2) amount to 0.13--0.35 of these masses. Taking account the star formation efficiency (~ 0.1), the increase in M(bulge) in those NLS1s in the near future (~< 10^{7.5} yr) is expected not to be a huge fraction (1--5% of the preexisting stars). Bulge growth may have finished before BH growth, or bulge--BH coevolution may proceed with many, occasional discrete events, where one coevolution event produces only a small amount of mass growth of BHs and of bulges. We also discuss the ratios of star-formation rate--to--gas accretion rate onto BHs, finding that two NLS1s have very small ratios (~ 1) compared with the M(bulge)/M(BH) ratios found in active and inactive galaxies (~ 700). This huge difference suggests either the non-overlapped coevolution, long star formation duration or temporarily high accretion rate during NLS1 phase.Comment: 29 pages, 8 figures, Accepted for publication in The Astrophysical Journa

Interferometric 12CO(J=2-1) image of the Nuclear Region of Seyfert 1 Galaxy NGC 1097

We have mapped the central region of the Seyfert 1 galaxy NGC 1097 in 12CO(J=2-1) with the Submillieter Array (SMA). The 12CO(J=2-1) map shows a central concentration and a surrounding ring, which coincide respectively with the Seyfert nucleus and a starburst ring. The line intensity peaks at the nucleus, whereas in a previously published 12CO(J=1-0) map the intensity peaks at the starburst ring. The molecular ring has an azimuthally averaged 12CO(J=2-1)/(J=1-0) intensity ratio (R21) of about unity, which is similar to those in nearby active star forming galaxies, suggesting that most of the molecular mass in the ring is involved in fueling the starburst. The molecular gas can last for only about 1.2\times10^8 years without further replenishment assuming a constant star formation rate and a perfect conversion of gas to stars. The velocity map shows that the central molecular gas is rotating with the molecular ring in the same direction, while its velocity gradient is much steeper than that of the ring. This velocity gradient of the central gas is similar to what is usually observed in some Seyfert 2 galaxies. To view the active nucleus directly in the optical, the central molecular gas structure can either be a low-inclined disk or torus but not too low to be less massive than the mass of the host galaxy itself, be a highly-inclined thin disk or clumpy and thick torus, or be an inner part of the galactic disk. The R21 value of ~1.9 of the central molecular gas component, which is significantly higher than the value found at the molecular gas ring, indicates that the activity of the Seyfert nucleus may have a significant influence on the conditions of the molecular gas in the central component.Comment: 22 pages, 4 figures, accepted by Ap

Formation of a Massive Black Hole at the Center of the Superbubble in M82

We performed 12CO(1-0), 13CO(1-0), and HCN(1-0) interferometric observations of the central region (about 450 pc in radius) of M82 with the Nobeyama Millimeter Array, and have successfully imaged a molecular superbubble and spurs. The center of the superbubble is clearly shifted from the nucleus by 140 pc. This position is close to that of the massive black hole (BH) of >460 Mo and the 2.2 micron secondary peak (a luminous supergiant dominated cluster), which strongly suggests that these objects may be related to the formation of the superbubble. Consideration of star formation in the cluster based on the infrared data indicates that (1) energy release from supernovae can account for the kinetic energy of the superbubble, (2) the total mass of stellar-mass BHs available for building-up the massive BH may be much higher than 460 Mo, and (3) it is possible to form the middle-mass BH of 100-1000 Mo within the timescale of the superbubble. We suggest that the massive BH was produced and is growing in the intense starburst region.Comment: 9 pages, 3 figures, to appear in ApJ Lette

Vascular E-selectin expression correlates with CD8 lymphocyte infiltration and improved outcome in Merkel cell carcinoma

Merkel cell carcinoma (MCC) is an aggressive, polyomavirus-linked skin cancer. While CD8 lymphocyte infiltration into the tumor is strongly correlated with improved survival, these cells are absent or sparse in most MCCs. We investigated whether specific mechanisms of T-cell migration may be commonly disrupted in MCC tumors with poor CD8 lymphocyte infiltration. Intratumoral vascular E-selectin, critical for T-cell entry into skin, was downregulated in the majority (52%) of MCCs (n=56), and its loss was associated with poor intratumoral CD8 lymphocyte infiltration (p<0.05; n=45). Importantly, survival was improved in MCC patients whose tumors had higher vascular E-selectin expression (p<0.05). Local nitric oxide (NO) production is one mechanism of E-selectin downregulation and it can be tracked by quantifying nitrotyrosine, a stable biomarker of NO-induced reactive nitrogen species (RNS). Indeed, increasing levels of nitrotyrosine within MCC tumors were associated with low E-selectin expression (p<0.05; n=45) and decreased CD8 lymphocyte infiltration (p<0.05, n=45). These data suggest that one mechanism of immune evasion in MCC may be restriction of T cell entry into the tumor. Existing therapeutic agents that modulate E-selectin expression and/or RNS generation may restore T cell entry and could potentially synergize with other immune-stimulating therapies