Case Report Asymptomatic Congenital Hyperinsulinism due to a Glucokinase-Activating Mutation, Treated as Adrenal Insufficiency for Twelve Years

Congenital hyperinsulinism (CHI) caused by a glucokinase-(GCK-) activating mutation shows autosomal dominant inheritance, and its severity ranges from mild to severe. A 43-year-old female with asymptomatic hypoglycemia (47 mg/dL) was diagnosed as partial adrenal insufficiency and the administration of hydrocortisone (10 mg/day) was initiated. Twelve years later, her 8-monthold grandchild was diagnosed with CHI. Heterozygosity of exon 6 c.590T>C (p.M197T) was identified in a gene analysis of GCK, which was also detected in her son and herself. The identification of GCK-activating mutations in hyperinsulinemic hypoglycemia patients may be useful for a deeper understanding of the pathophysiology involved and preventing unnecessary glucocorticoid therapy

Effects of Fe fertilizer eluate on the growth of Sargassum horneri at the germling and immature stages

To aid in the restoration of coastal barren ground areas, it is important to clarify the effects of chelated iron on the growth of seaweed. In particular, for the further development of practical methods to promote seaweed growth, Fe-binding organic ligands, such as humic substances (HSs) composed of humus materials, rather than Fe-binding inorganic ligands, such as ethylenediaminetetraacetic acid (EDTA), should be investigated. In this study, the effects of an Fe fertilizer, made from HSs and steelmaking slag, on the growth of the brown alga Sargassum horneri at the germling and immature stages were examined. The addition of the Fe fertilizer eluate containing Fe organic ligand complexes clearly promoted the growth of S. horneri at the germling and immature stages. It was also clear that the effect of Fe concentration in the Fe fertilizer eluate on the growth rate was almost the same as that of Fe–EDTA. Moreover, the addition of the Fe fertilizer eluate had a great effect on the brown color of S. horneri thalli and promoted the increased content of photosynthetic pigments, such as chlorophyll a. Based on these experimental results, the application of the Fe fertilizer containing Fe organic ligand complexes is expected to become an effective method for the restoration of the barren ground phenomenon in Fe-deficient coastal areas. © 2015 Springer Science+Business Media DordrechtEmbargo Period 12 month

Erratum to: Contrasting effects of blue and red LED irradiations on the growth of Sargassum horneri during the germling and immature stages

The original version of this article unfortunately contained a mistake. Figure 7 was incorrect. The correct Figure is given below: (Figure presented). © 2017, Springer Science+Business Media Dordrecht.Embargo Period 12 month

Contrasting effects of blue and red LED irradiations on the growth of Sargassum horneri during the germling and immature stages

The brown seaweed Sargassum horneri (Sargassaceae) is important for marine environment conservation. It could be used for a food material, medical applications, and future biofuel production. We compared the growth of S. horneri cultures under single wavelength blue and red light during the germling and immature stages. The growth rate based on the thallus area of S. horneri during the germling stage was faster under blue LED light than under red LED light. Furthermore, based on the wet weight of S. horneri, during the immature stage, blue LED light resulted in a faster growth rate than red LED light. Moreover, during the immature stage, compared with red LED light, blue LED light tended to increase the content of photosynthetic pigments. We conclude that use of blue LED light in indoor tanks during the germling and immature stages will improve the efficiency of S. horneri culture. © 2016 Springer Science+Business Media DordrechtEmbargo Period 12 month

Asymptomatic Congenital Hyperinsulinism due to a Glucokinase-Activating Mutation, Treated as Adrenal Insufficiency for Twelve Years

Congenital hyperinsulinism (CHI) caused by a glucokinase- (GCK-) activating mutation shows autosomal dominant inheritance, and its severity ranges from mild to severe. A 43-year-old female with asymptomatic hypoglycemia (47 mg/dL) was diagnosed as partial adrenal insufficiency and the administration of hydrocortisone (10 mg/day) was initiated. Twelve years later, her 8-month-old grandchild was diagnosed with CHI. Heterozygosity of exon 6 c.590T>C (p.M197T) was identified in a gene analysis of GCK, which was also detected in her son and herself. The identification of GCK-activating mutations in hyperinsulinemic hypoglycemia patients may be useful for a deeper understanding of the pathophysiology involved and preventing unnecessary glucocorticoid therapy

Multidisciplinary approach for treatment of a dentigerous cyst – marsupialization, orthodontic treatment, and implant placement: a case report

Abstract Background Dentigerous cysts are common odontogenic cysts associated with unerupted teeth. We describe a previously unreported case of a multidisciplinary approach using surgical, orthodontic, and implant treatment to establish the occlusion for a patient with a maxillary dentigerous cyst. Case presentation An 18-year-old Japanese woman visited our hospital with a chief complaint of gingival swelling in her anterior maxillary region, midline diastema, and tooth crowding. Her main symptom was this gingival swelling. A panoramic radiograph revealed a radiolucent area, 30 mm in diameter, round in shape, and with well-demarcated margins including the maxillary canine. Computed tomography revealed a cystic cavity filled with homogeneous fluid of the same density as water, and a distolingually inclined canine. Our clinical diagnosis was maxillary dentigerous cyst with an unerupted distolingually inclined canine. The selected treatment was marsupialization of the dentigerous cyst, followed by orthodontic traction of the unerupted canine, and simultaneous orthodontic treatment of the midline diastema and tooth crowding. The orthodontic traction failed because the canine did not erupt completely, and the canine was extracted. The treatment plan was then changed to implant treatment after the tooth crowding and midline diastema had been improved. Because the alveolar ridge width was inadequate, the implant was placed after a two-stage implant treatment; therefore, a satisfactory occlusion could be achieved. Our patient did not experience any complications, and the cyst has not recurred. A radiograph taken 7 years after marsupialization of the dentigerous cyst revealed that the cystic cavity had been replaced by new bone. Conclusions In general, orthodontic traction of an unerupted tooth after marsupialization should be the best option. However, if orthodontic traction fails, a multidisciplinary approach involving implant treatment may be necessary. We describe a case in which a multidisciplinary approach involving surgical, orthodontic, and implant treatment was used to establish a satisfactory occlusion for a patient with a dentigerous cyst