An On-the-Road Comparison of In-Vehicle Navigation Assistance Systems

We compared system performance and driver opinion of 3 in-vehicle navigation aids - two advanced traveler information systems (ATISs; Ali-Scout and TetraStar) and written instructions - when used on the road concurrently under identical conditions. Few drivers in the study had difficulty finding initial routes or became lost. Users of Ali-Scout, an ATIS that utilizes traffic information in routing, drove longer-distance routes, got lost more frequently, and gave their system less positive ratings than did TetraStar users. Users of the 2 ATISs traversed routes that were significantly shorter in duration than those driven by users of written instructions. The time savings benefit of the advanced technology systems over written instructions was greatest during peak traffic conditions. Drivers who were familiar with the road network, overall, had less difficulty finding destinations and drove shorter-duration routes than drivers who were unfamiliar with the road network. Actual or potential applications of this research include improving the design of technologies that provide navigation assistance to travelers.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67382/2/10.1518_001872099779591222.pd

Book reviews

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43527/1/11116_2004_Article_BF00172656.pd

Pck-ing up steam: widening the salmonid gluconeogenic gene duplication trail

Rainbow trout have, as salmonid fish species, undergone sequential genome duplication events in their evolutionary history. In addition to a teleost-specific whole genome duplication approximately 320–350 million years ago, rainbow trout and salmonids in general underwent an additional salmonid lineage-specific genome duplication event approximately 80 million years ago. Through the recent sequencing of salmonid genome sequences, including the rainbow trout, the identification and study of duplicated genes has become available. A particular focus of interest has been the evolution and regulation of rainbow trout gluconeogenic genes, as recent molecular and gene expression evidence points to a possible contribution of previously uncharacterized gluconeogenic gene paralogues to the rainbow trout long-studied glucose intolerant phenotype. Since the publication of the initial rainbow trout genome draft, resequencing and annotation have further improved genome coverage. Taking advantage of these recent improvements, we here identify a salmonid-specific genome duplication of ancestral mitochondrial phosphoenolpyruvate carboxykinase 2 isoenzyme, we termed pck2a andpck2b. Cytosolic phosphoenolpyruvate carboxykinase (Pck1) and, more recently mitochondrial Pck2, are considered to be the rate-limiting enzymes in de novo gluconeogenesis. Following in silico confirmation of salmonid pck2a and pck2b evolutionary history, we simultaneously profiled cytosolic pck1 and mitochondrial pck2a and pck2b expression in rainbow trout liver under several experimental conditions known to regulate hepatic gluconeogenesis. Cytosolic pck1 abundance was increased by nutritional (diets with a high protein to carbohydrate ratio compared to diets with a low carbohydrate to protein ratio) and glucoregulatory endocrine factors (glucagon and cortisol), revealing that the well-described transcriptional regulation of pck1 in mammals is present in rainbow trout. Conversely, and in contrast to mammals, we here describe endocrine regulation of pck2a (decrease in abundance in response to glucagon infusion), and nutritional, social-status-dependent and hypoxiadependent regulation of pck2b. Specifically, pck2b transcript abundance increased in trout fed a diet with a low protein to carbohydrate ratio compared to a diet with a high protein to carbohydrate ratio, in dominant fish compared to subordinate fish as well as hypoxia. This specific and differential expression of rainbow trout pck2 ohnologues is indicative of functional diversification, and possible functional consequences are discussed in light of the recently highlighted gluconeogenic roles of mitochondrial pck2 in mammalian models

The Influence of Hearing Impairment on Driving Avoidance Among a Large Cohort of Older Drivers

As people age, some of the commonly experienced psychomotor, visual, and cognitive declines can interfere with the ability to safely drive, often leading to situational avoidance of challenging driving situations. The effect of hearing impairment on these avoidance behaviors has not been comprehensively studied. Data from the American Automobile Association (AAA) Longitudinal Research on Aging Drivers (LongROAD) study were used to assess the effect of hearing impairment on driving avoidance, using three measures of hearing. Results indicated that hearing loss plays a complex role in driving avoidance, and that an objective hearing measure was a stronger predictor than hearing aid use and self-rated hearing. Greater hearing impairment was related to less nighttime and freeway driving, more trips farther than 15 mi from home, and lower odds of avoiding peak driving times. The moderating influence of hearing on both vision and cognition is also discussed, along with study implications and future research.http://deepblue.lib.umich.edu/bitstream/2027.42/193065/2/vivoda-et-al-2021-the-influence-of-hearing-impairment-on-driving-avoidance-among-a-large-cohort-of-older-drivers.pdfPublished versio