Lack of cardiovascular side effects of the new tricyclic antidepressant tianeptine. A double-blind, placebo-controlled study in young healthy volunteers.

In a double-blind, placebo-controlled, crossover study, the effects of therapeutic doses of the new tricyclic antidepressant tianeptine on cardiovascular function were closely monitored in 21 healthy volunteers during a 2-week treatment period. Blood pressure measurements, ECG recording, 24-h Holter monitoring, and echocardiography were carried out at 1-week intervals. Isotopic ventriculography was measured twice under each treatment. Tianeptine did not produce orthostatic hypotension or increase heart rate. No ECG changes could be observed and the cardiac conduction time remained unchanged. One subject presented with an increase in frequency of ventricular premature beats that could not be definitely attributed to the drug. Cardiac output assessed at rest and after a bicycle exercise stress test was not altered. The present study suggests that tianeptine is a tricyclic antidepressant endowed with less cardiac toxicity than classical tricyclic antidepressants.Clinical TrialControlled Clinical TrialJournal Articleinfo:eu-repo/semantics/publishe

Avaliação dos fluxos das valvas aórtica e pulmonar com ecocardiografia Doppler pulsátil em cães clinicamente sadios Evaluation of aortic and pulmonary valves flow with pulsed-wave Doppler echocardiography in healthy dogs

Avaliaram-se com Doppler pulsátil os fluxos das valvas aórtica (AO) e pulmonar (Pul) por meio de análise qualitativa (presença de regurgitações valvares e características do espectro avaliado) e quantitativa, com obtenção de parâmetros ecocardiográficos como velocidades máxima (V. Max.) e média (V. Me.), integral de velocidade (VTI), tempo de aceleração (TA) e ejeção (TE), de 30 cães considerados clinicamente sadios por meio de exames físico, laboratoriais, eletrocardiográfico, ecocardiográfico (modos uni e bidimensional), radiográfico de tórax e mensuração da pressão arterial sistêmica. Obtiveram-se os seguintes resultados para os referidos parâmetros: V.max. AO= 1,22± 19,38m/s; V. Me. AO= 0,72± 0,08m/s; VTI AO= 0,14± 0,02m; TA AO= 38,80± 11,29ms; TE AO= 197,90± 24,77ms; V. Max. Pul= 0,95± 0,18m/s; V. Me. Pul= 0,63± 0,10m/s; VTI Pul= 0,13± 0,02m; TA Pul= 70,97± 18,87ms; TE Pul= 203,70± 28,98ms. Em apenas três animais observou-se regurgitação pulmonar. Alguns parâmetros apresentaram correlação negativa com a variável freqüência cardíaca (VTI AO, TE AO, VTI Pul, TA Pul, TE Pul); outros correlação positiva com a variável peso (VTI AO, TA AO, TE AO, VTI Pul, TE Pul,) e não se observou influência da variável sexo na maioria dos parâmetros avaliados. Na comparação entre os dois fluxos, observaram-se V. Max. AO e V. Me. AO maiores que V. Max. Pul. e V. Me. Pul., respectivamente, VTI AO maior que VTI Pul, e TA AO menor que TA Pul.<br>This study evaluated aortic (AO) and pulmonary (Pul) valves flow with pulsed-wave Doppler by qualitative (presence of valvar insufficiency and characteristic of flow profile) and quantitative analysis, and the following echocardiographic parameters were obtained: peak (PV) and mean (MV) velocities, velocity-time integral (VTI), acceleration (AT) and ejection (ET) time. Thirty dogs were studied, and to be considered normal, physical, laboratory, electrocardiographic, echocardiographic (uni and bidimensional mode) exams, thoracic radiography, and measurement of the blood pressure were accomplished, and the following echocardiographic parameters were obtained: AO PV= 1.22± 19.38m/s; AO MV= 0.72± 0.08m/s; AO VTI= 0.14± 0.02m; AO AT= 38.80± 11.29ms; AO ET= 197.90± 24.77ms; Pul PV= 0.95± 0.18m/s; Pul MV= 0.63± 0.10m/s; Pul VTI= 0.13± 0.02m; Pul AT= 70.97± 18.87ms; Pul ET= 203.70± 28.98ms. Heart rate presented negative correlation with AO VTI, AO ET, Pul VTI, Pul AT, Pul ET, and the variable weight had positive correlation with AO VTI, AO AT, AO ET, Pul VTI, Pul ET, differently from the gender, that had no influence on the evaluated parameters. The comparison of aortic and pulmonary valves flow demonstrated AO PV and AO MV higher than Pul PV and Pul MV, respectively, AO VTI higher than Pul VTI, and Pul AT higher than AO AT

The spectrum of mitral regurgitation in idiopathic mitral valve prolapse: a color Doppler study.

To characterize the spectrum of mitral regurgitation in mitral valve prolapse, one hundred patients were studied by color Doppler flow mapping. The findings were correlated with the clinical presentation and with the possible complications. Mitral regurgitation was absent in 46 patients, mild in 26 patients, moderate in 18 patients and severe in 10 patients. The jet orientation was central in 15 patients, antero-medial in 13 patients and postero-lateral in 26 patients. The regurgitation was early systolic in 7 patients, late systolic in 20 patients and holosystolic in 27 patients. A good agreement was observed between the color flow patterns and the presence, timing and radiation of a murmur. Systolic clicks were not predictors of the presence or the severity of regurgitation. The grade of mitral regurgitation was positively correlated with, age, left heart enlargement and valvular redundancy. No sex difference was observed. The prevalence of serious arrhythmias or cerebral ischemic events was not significantly increased when a regurgitation was present.Journal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe