1 research outputs found
Evaluation of skin irritation potentials of different cosmetic products in Turkish market by reconstructed human epidermis model
Human skin is a protective barrier against the toxic effects of
cosmetics. Marketing of cosmetic products with ingredients tested on
animals was prohibited in 2013. Since then, safety evaluation of
cosmetic products is performed by using alternative in vitro toxicity
tests. In vitro 3-D reconstructed human epidermis (RhE) tissue models
are now used to define skin irritation/corrosion potentials of cosmetic
ingredients and end-products. The main aim of this study was to evaluate
skin irritation potentials of topically used cosmetic end-products which
were marketed in Turkey during 2015-2017, by using the EpiDerm in vitro
3D-human skin model. Sixty widely used cosmetic products were collected
from different markets/cosmetic shops. Among hair care products, only
one shampoo was found to be strong/severe skin irritant/possible
corrosive while 22 shampoos were moderate skin irritant and 11 shampoos
were moderate to mild skin irritant. Among 6 skin care products, one was
found to be moderate to mild skin irritant. We can suggest that
alternative in vitro tests should continuously be used to test both the
ingredients and the final cosmetic formulations