Czy można lekceważyć łagodnego guza serca? Opis chorej ze śluzakiem serca powikłanym zatorowością, wstrząsem septycznym i zespołem wykrzepiania wewnątrznaczyniowego

W pracy, przedstawiono przypadek młodej kobiety, u której zdiagnozowano „de novo” śluzaka lewego przedsionka. Skrajnie ciężki przebieg choroby doprowadził do nieodwracalnych powikłań i trwałego uszczerbku na zdrowiu w tym amputacji w zakresie obu kończyn dolnych. W proces diagnostyczny zaangażowany był zespół doświadczonych lekarzy, a terapia wymagała wysokospecjalistycznych zabiegów z zakresu medycyny zachowawczej oraz operacyjnej.

Czy można lekceważyć łagodnego guza serca? Opis chorej ze śluzakiem serca powikłanym zatorowością, wstrząsem septycznym i zespołem wykrzepiania wewnątrznaczyniowego

W pracy, przedstawiono przypadek młodej kobiety, u której zdiagnozowano de novo śluzaka lewego przedsionka. Skrajnie ciężki przebieg choroby doprowadził do nieodwracalnych powikłań i trwałego uszczerbku na zdrowiu w tym amputacji w zakresie obu kończyn dolnych. W proces diagnostyczny zaangażowany był zespół doświadczonych lekarzy, a terapia wymagała wysokospecjalistycznych zabiegów z zakresu medycyny zachowawczej oraz operacyjnej.Słowa kluczowe: śluzak serca, powikłania zakrzepowo-zatorow

Factors that Predict Parental Willingness to Have Their Children Vaccinated against HPV in a Country with Low HPV Vaccination Coverage

Background: Adolescent HPV (Human Papilloma Virus) vaccination is yet to be introduced as a mandatory program in Poland. Polish literature on factors associated with adolescent HPV vaccination is scant, despite the fact that uptake is one of the poorest in the European Union. Objectives: To assess HPV awareness and identify independent predictors for parental willingness to have their children vaccinated against HPV. Methods: All parents of first grade students from three selected high schools in Zgorzelec, Poland, who participated in parent–teacher meetings at the time the study was conducted, had their children unvaccinated regarding HPV, and who gave informed consent to participate were included. There were 600 first grade students; 9 were vaccinated against HPV. This left 591 parents who met the eligibility criteria; the response rate was 76.1%. Results: Awareness of HPV was reported by 55.3% of 450 parents (mean age 42 years, 70.9% females); 85.1% expressed their willingness to vaccinate their children against HPV; 31.3% identified HPV as a sexually transmitted pathogen, and 36.2% identified it as a risk factor of cervical cancer. Multivariable logistic regression analyses indicated that being employed (OR 2.09; 95% CI: 1.10–3.86), having positive attitudes toward vaccines (OR 3.02; 95% CI: 1.34–6.49), previous information about HPV (OR 2.02; 95% CI: 1.17–3.51), and concerns about the side effects of the HPV vaccine (OR 0.60; 95% CI: 0.35–0.99) were independent predictors of parents’ willingness to vaccinate. Conclusions: Attitudes regarding their child being vaccinated against HPV were positive among Polish parents, even though awareness and knowledge of HPV in this group were low. Most of the significant factors that influenced their willingness were modifiable, such as being informed about HPV and having positive attitudes toward vaccines. Future interventions should focus specifically on vulnerable subgroups, such as unemployed parents

Genetic contribution to all cancers: the first demonstration using the model of breast cancers from Poland stratified by age at diagnosis and tumour pathology

The aim of the study is to verify the hypothesis that genetic polymorphisms are associated with the predisposition to all malignancies. Using as a model breast cancers from the homogenous Polish population (West Pomeranian region) after stratification of 977 patients by age at diagnosis (under 51 years and above 50 years) and by tumour pathology (ductal cancers––low and high grade, lobular cancers, ER-positive/negative) we tested this hypothesis. Altogether 20 different groups of breast cancer cases have been analyzed. The results were compared to a group of unaffected controls that were matched by age, sex, ethnicity and geographical location and originated from families without cancers of any site among relatives. Molecular alterations selected for analyses included those which have been previously recognized as being associated with breast cancer predisposition. Statistically significant differences between the breast cancer cases and controls were observed in 19 of the 20 analyzed groups. Genetic changes were present in more than 90% of the breast cancer patients in 18 of 20 groups. The highest proportion of cases with constitutional changes—99.3% (139/140) was observed for lobular cancers. The number and type of genetic marker and/or the level of their association with the specific cancer predisposition was different between groups. Markers associated with majority of groups included: BRCA1, CHEK2, p53, TNRnTT, FGFRnAA, XPD CC/AA and XPD GG. Some markers appeared to be group specific and included polymorphisms in CDKN2A, CYP1B1, M3K nAA, and RS67