Взаємозв'язок регуляції водно-сольового обміну і гемостазу

В работе установлено, что перестройка гормональной регуляции водносолевого обмена в ответ на острую постегеморрагическую гиповолемию направлена на задержку в организме воды и ионов натрия на фоне увеличения интенсивности вазоспастического регуляторного сигнала, что характеризуется увеличением содержания в крови ангиотензина II, антидиуретического гормона и уменьшением концентрации α-предсердного натрийуретического пептида (ПНП). Концентрация в крови а-ПНП выявляет отрицательную корреляционную взаимозависимость с параметрами функциональной активности тромбоцитов. Основным фактором, способствующим активации тромбоцитов в условиях острой изоосмолярной гипогидратации, является ангиотензин II, действие которого модулируется противоположными эффектами α-ПНП.It is found, that the hormonal regulation of a water-salt balance after sharp isoosmotic hyperhydration is directed to a delay in the body of water and sodium on the background of actirftion of vasoconstrictory mechanisms due to the increase of the blood content of angiotensin II, antydiuratic hormone and the reduction of concentration α-atrial natriuretic peptide (α-NUP) between them. Negative correlation concentration in blood α-NUP reveals and parameters of functional activity of thrombocytes. A major factor promoting activation of thrombocytes in conditions of a sharp isoosmotic hyperhydration is the angiotensin II action of which is balanced by opposite effects α-NUP

The best defence is not being there : avoidance of larger carnivores is not driven by risk intensity

ACKNLOWDGEMENTS We would like to thank the Cairngorms Connect, Forestry and Land Scotland, Wildland.Ltd, the Royal Society for the Protection of Birds and NatureScot for providing access to the study sites, and their staff who supported our work. We would like to thank Thomas MacDonell and Wildland.Ltd in particular for their in-kind contributions and continued support. Comments by two anonymous reviewers and the journal’s associate editor contributed to improve this article. The study was funded by Forestry and Land Scotland, the School of Biological Sciences (University of Aberdeen) and Wildland.Ltd.Peer reviewedPublisher PD

Lethal interactions among forest-grouse predators are numerous, motivated by hunger and carcasses, and their impacts determined by the demographic value of the victims

ACKNOWLEDGEMENTS We would like to thank two anonymous reviewers for their critical read of an earlier version of this manuscript and the insightful comments to improve it. This work was funded by Forestry and Land Scotland and the School of Biological Sciences (University of Aberdeen).Peer reviewedPublisher PD

Strong inference from transect sign surveys : combining spatial autocorrelation and misclassification occupancy models to quantify the detectability of a recovering carnivore

Acknowledgements We are very grateful for the input provided by Elizabeth Croose, Declan O'Mahony and Denise O'Meara on pine marten survey methodology and related constraints, which we hope this paper will go some way toward relieving. Christopher Sutherland was incredibly helpful in discussion of occupancy modelling techniques. We would also like to thank Thys Simpson, Colin McClean and Shaila Rao for arranging access to private estates for surveying. Funding — Forest Enterprise Scotland and the University of Aberdeen provided funding for the project. The Carnegie Trust supported the lead author, E. McHenry, in this research through the award of a tuition fees bursary.Peer reviewedPublisher PD

Evaluating diversionary feeding as a method to resolve conservation conflicts in a recovering ecosystem

Funding: Scottish University Partnership of Environmental Research (SUPER DTP), Grant/Award Number: NE/S007342/1; Forestry and Land Scotland.1. The recovery of mammalian predators of conservation concern in Europe is a success story, but their impact on some prey species of conservation concern may cause conservation dilemmas. This calls for effective intervention strategies that mitigate predator impacts without compromising their recovery. 2. We evaluated diversionary feeding as a management intervention tool to reduce depredation on nests of rapidly declining Western capercaillies in Scotland. We studied the influence of diversionary feeding provision on the fates of artificial nests deployed using a replicated and representative randomised landscape-scale experiment. This comprised 30 'paired' control (no diversionary feeding) and treatment (diversionary feeding applied) sites, 60 in total, each containing six artificial nests distributed across 600 km2. The experiment was replicated over 2 years, and in the second year, the control-treatment pairs were reversed, yielding 60 treatment and 60 control sites and 720 artificial nests. 3. Diversionary feeding substantially reduced depredation of artificial nests, translating into an 82.5% increase in predicted nest survival over 28 days of incubation. The increase in survival was mostly accounted for by a reduction in the probability that a pine marten, the main nest predator, consumed or cached eggs. Diversionary food also significantly reduced nest predation by badgers, although the magnitude of this effect varied by year. 4. Synthesis and applications. Diversionary feeding is an easily employable method shown in this study to reduce predator impact (functional) without lethal (numerical) intervention. Managers should proceed with its application for conserving capercaillie in Scotland without delay.Peer reviewe

Divination: Exemplifying and Configuring Archetypes in Ceramics

Abstract/Summary Dissertation Divination: Exemplifying and Configuring Archetypes in Ceramics is a study of my research practice. The cards of the tarot can be used as a conceptual framework and source of inspiration for making ceramic sculptures. The cards can be used to understand the creative process as an expression of archetypes. My dissertation discusses these archetypes from the tarot cards, both in their historical operation, their manifestation in my art practice, as well as, examining approaches taken to these archetypes by other artists such as Salvador Dali and Niki de Saint Phalle. The theoretical basis for the dissertation is informed by the writings of Carl G. Jung who has proposed concepts dealing with creativity, coincidence, a collective unconscious and archetypes. These ideas form a model for the understanding of my studio work. As background, the dissertation examines examples of artworks that could be seen to be drawn from a collective unconscious. Studio Work The studio work consists of a series of ceramic sculptures formulating the archetypes that I have derived from the tarot cards. The three dimensional clay, with found inclusions, examines the idea of specific archetypes. These archetypes are titled in the works including: The Fool, Strength, The Magician, Tarot Sun, The Empress II, The Lovers, Empress l, The Chariot I and II The Angel Temperance, The Tarot Devil and The World. The ceramic objects have been created in clay using handbuilding techniques. The clay was such that it could include found ceramic pieces and be refired. The pieces have been re-fired many times to achieve a variety of glaze effects. The works range in size from 30-60 cms approximately and include freestanding sculptures and complementing flat wall works

Socioeconomic Outcome and Quality of Life in Adults after Status Epilepticus: A Multicenter, Longitudinal, Matched Case–Control Analysis from Germany

BackgroundThere is a lack of data concerning socioeconomic outcome and quality of life (QoL) in patients after status epilepticus (SE) in Germany.Patients and methodsAdult patients treated between 2011 and 2015 due to SE at the university hospitals in Frankfurt, Greifswald, and Marburg were asked to fill out a questionnaire regarding long-term outcome of at least 3 months after discharge. The SE cohort consisted of 25.9% patients with an acute symptomatic, 42% with a remote symptomatic and previous epilepsy, 22.2% with a new-onset remote symptomatic, and 9.9% with other or unknown etiology. A matched case–control analysis was applied for comparison with patients with drug refractory epilepsy and seizure remission, both not previously affected by SE.ResultsA total of 81 patients (mean age: 58.7 ± 18.0 years; 58% female) participated. A non-refractory course was present in 59.3%, while 27.2% had a refractory SE (RSE) and 13.6% had a superrefractory SE (SRSE). Before admission, a favorable modified Rankin Scale (mRS) of 0–3 was found in 82.7% (67/81), deteriorating to 38.3% (31/81) (p = 0.003) at discharge. The majority returned home [51.9% (42/81)], 32.1% entered a rehabilitation facility, while 12.3% were transferred to a nursing home and 3.7% to another hospital. The overall mRS at follow-up did not change; 61.8% (45/74) reached an mRS of 0–3. In RSE and SRSE, the proportion with a favorable mRS increased from 45.5% at discharge to 70% at follow-up, while QoL was comparable to a non-refractory SE course. Matched epilepsy controls in seizure remission were treated with a lower mean number of anticonvulsants (1.3 ± 0.7) compared to controls with drug refractory epilepsy (1.9 ± 0.8; p < 0.001) or SE (1.9 ± 1.1; p < 0.001). A major depression was found in 32.8% of patients with SE and in 36.8% of drug refractory epilepsy, but only in 20.3% of patients in seizure remission. QoL was reduced in all categories (QOLIE-31) in SE patients in comparison with patients in seizure remission, but was comparable to patients with drug refractory epilepsy.DiscussionPatients after SE show substantial impairments in their QoL and daily life activities. However, in the long term, patients with RSE and SRSE had a relatively favorable outcome comparable to that of patients with a non-refractory SE course. This underlines the need for efficient therapeutic options in SE

Agreement of general practitioners with the guideline-based stepped-care strategy for patients with osteoarthritis of the hip or knee: A cross-sectional study

Background: To improve the management of hip or knee osteoarthritis (OA), a multidisciplinary guideline-based stepped-care strategy (SCS) with recommendations regarding the appropriate non-surgical treatment modalities and optimal sequence for care has been developed. Implementation of this SCS in the general practice may be hampered by the negative attitude of general practitioners (GPs) towards the strategy. In order to develop a tailored implementation plan, we assessed the GPs' views regarding specific recommendations in the SCS and their working procedures with regard to OA. Methods. A survey was conducted among a random sample of Dutch GPs. Questions included the GP's demographical characteristics and the practice setting as well as how the management of OA was organized and whether the GPs supported the SCS recommendations. In particular, we assessed GP's views regarding the effectiveness of 14 recommended and non-recommended treatment modalities. Furthermore, we calculated their agreement with 7 statements based on the SCS recommendations regarding the sequence for care. With a linear regression model, we identified factors that seemed to influence the GPs' agreement with the SCS recommendations. Results: Four hundred fifty-six GPs (37%) aged 30-65 years, of whom 278 males (61%), responded. Seven of the 11 recommended modalities (i.e. oral Non-Steroidal Anti-Inflammatory Drugs, physical therapy, glucocorticoid intra-articular injections, education, lifestyle advice, acetaminophen, and tramadol) were considered effective by the majority of the GPs (varying between 95-60%). The mean agreement score, based on a 5-point scale, with the recommendations regarding the sequence for care was 2.8 (SD = 0.5). Ten percent of the variance in GPs' agreement could be explained by the GPs' attitudes regarding the effectiveness of the recommended and non-recommended non-surgical treatment modalities and the type of practice. Conclusion: In general, GPs support the recommendations in the SCS. Therefore, we expect that their attitudes will not impede a successful implementation in general practice. Our results provide sev