3 research outputs found
ΠΠΠΠΠΠ ΠΠΠΠ―ΠΠΠ― Π‘Π’Π ΠΠΠ ΠΠΠΠΠ’ΠΠ ΠΠΠΠ‘Π’ΠΠ ΠΠ ΠΠΠ ΠΠΠΠΠΠΠ‘Π’Π¬
ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΡΠ²ΠΎΡΠΎΡΠΎΡΠ½ΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ Ρ Π΄Π΅ΡΠ΅ΠΉ Π΄ΠΎΡΠΊΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ° Ρ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²ΠΎΠΌ Π°ΡΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΏΠ΅ΠΊΡΡΠ°
The aim of this study was to investigate the serum concentration of amino acids, as well as their derivatives, in children with an autism spectrum disorder of preschool age. Material and methods. There are 35 boys with ASD (ICD-10: F84.0) of preschool age (3-6 years) and 35 healthy peers were examined. Determination of serum concentration of amino acids and their derivatives was carried out by high performance liquid chromatography (HPLC) on a PerkinElmer S200 chromatograph (PerkinElmer, USA). Results. It was found that the concentration of leucine, lysine, threonine, tryptophan, arginine, glutamine, serine, 1-methylhistidine, Ξ±-aminobutyric acid and taurine was characterized by a significant decrease relative to the control values by 11%, 22%, 19%, 22%, 34%, 17%, 13%, 29%, 20% and 14%, respectively. It is also worth noting a 16% decrease in serum phenylalanine, approaching significant in significance. At the same time, the hydroxyproline serum concentration in children with autism exceeded the corresponding parameters in the control group by more than 3 times. In accordance with the results of a group comparison, a tight relationship with ASD was found for the concentration of hydroxyproline (Ξ² = 0.447; p = 0.001) and arginine (Ξ² = -0.238; p = 0.068). A model including the level of amino acids characterized by any significant group differences (1mh, Aab, Arg, Gln, Hypro, Leu, Lys, Ser, Thr, Trp, Tau) was associated with 26% of the variability of the presence of ASD (p = 0.001). Conclusions. Thus, the data obtained indicate a pronounced trend towards amino acid deficiency in children with ASD amid an increase in the concentration of hydroxyproline, which may be the link between autism and joint hypermobility. In turn, a deficiency of a number of amino acids, which are precursors of neurotransmitters, can lead to aggravation of neuropsychiatric disorders. In this regard, the correction of the amino acids metabolism may be one of the potential directions in the treatment of ASD.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ - ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠ²ΠΎΡΠΎΡΠΎΡΠ½ΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ ΠΈ ΡΡΠ΄Π° ΠΈΡ
ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²ΠΎΠΌ Π°ΡΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΏΠ΅ΠΊΡΡΠ° (Π ΠΠ‘) Π΄ΠΎΡΠΊΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°. ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ 35 ΠΌΠ°Π»ΡΡΠΈΠΊΠΎΠ² Ρ Π ΠΠ‘ (ΠΠΠ-10: F84.0) Π΄ΠΎΡΠΊΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ° (3-6 Π»Π΅Ρ) ΠΈ 35 Π·Π΄ΠΎΡΠΎΠ²ΡΡ
ΡΠ²Π΅ΡΡΡΠ½ΠΈΠΊΠΎΠ². ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΠ²ΠΎΡΠΎΡΠΎΡΠ½ΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ ΠΈ ΠΈΡ
ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π²ΡΡΠΎΠΊΠΎΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠ½ΠΎΠΉ Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΠΈ (ΠΠΠΠ₯) Π½Π° Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠ΅ PerkinElmer S200 (Β«PerkinElmerΒ», Π‘Π¨Π). Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π»Π΅ΠΉΡΠΈΠ½Π°, Π»ΠΈΠ·ΠΈΠ½Π°, ΡΡΠ΅ΠΎΠ½ΠΈΠ½Π°, ΡΡΠΈΠΏΡΠΎΡΠ°Π½Π°, Π°ΡΠ³ΠΈΠ½ΠΈΠ½Π°, Π³Π»ΡΡΠ°ΠΌΠΈΠ½Π°, ΡΠ΅ΡΠΈΠ½Π°, 1-ΠΌΠ΅ΡΠΈΠ»Π³ΠΈΡΡΠΈΠ΄ΠΈΠ½Π°, Ξ±-Π°ΠΌΠΈΠ½ΠΎΠΌΠ°ΡΠ»ΡΠ½ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ ΠΈ ΡΠ°ΡΡΠΈΠ½Π° Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π»ΠΈΡΡ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΡΠΌ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ
Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ Π½Π° 11, 22, 19, 22, 34, 17, 13, 29, 20 ΠΈ 14% ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ. ΠΡΠΌΠ΅ΡΠ΅Π½ΠΎ 16%-Π½ΠΎΠ΅ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ ΡΠ΅Π½ΠΈΠ»Π°Π»Π°Π½ΠΈΠ½Π° Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ, ΠΏΡΠΈΠ±Π»ΠΈΠΆΠ°ΡΡΠ΅Π΅ΡΡ ΠΏΠΎ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΠΈ ΠΊ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΠΌΡ. ΠΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠΏΡΠΎΠ»ΠΈΠ½Π° Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ Π΄Π΅ΡΠ΅ΠΉ Ρ Π°ΡΡΠΈΠ·ΠΌΠΎΠΌ ΠΏΡΠ΅Π²ΡΡΠ°Π»Π° ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π² ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ Π±ΠΎΠ»Π΅Π΅ ΡΠ΅ΠΌ Π² 3 ΡΠ°Π·Π°. Π ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΈΠΈ Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌΠΈ Π³ΡΡΠΏΠΏΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠ΅ΡΠ½Π°Ρ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ Ρ Π ΠΠ‘ Π±ΡΠ»Π° Π²ΡΡΠ²Π»Π΅Π½Π° Π΄Π»Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΉ Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠΏΡΠΎΠ»ΠΈΠ½Π° (Ξ²=0,447; Ρ=0,001) ΠΈ Π°ΡΠ³ΠΈΠ½ΠΈΠ½Π° (Ξ²=-0,238; Ρ=0,068). ΠΠΎΠ΄Π΅Π»Ρ, Π²ΠΊΠ»ΡΡΠ°ΡΡΠ°Ρ ΡΡΠΎΠ²Π΅Π½Ρ Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΠΈΡ
ΡΡ ΡΠΊΠΎΠ»ΡΠΊΠΎ-Π½ΠΈΠ±ΡΠ΄Ρ Π·Π½Π°ΡΠΈΠΌΡΠΌΠΈ Π³ΡΡΠΏΠΏΠΎΠ²ΡΠΌΠΈ ΠΎΡΠ»ΠΈΡΠΈΡΠΌΠΈ (1mh, Aab, Arg, Gln, Hypro, Leu, Lys, Ser, Thr, Trp, Tau), Π±ΡΠ»Π° ΡΠ²ΡΠ·Π°Π½Π° Ρ 26% Π²Π°ΡΠΈΠ°Π±Π΅Π»ΡΠ½ΠΎΡΡΠΈ Π½Π°Π»ΠΈΡΠΈΡ Π ΠΠ‘ (Ρ=0,001). ΠΡΠ²ΠΎΠ΄Ρ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡ ΠΎ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠΉ ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΠΈ ΠΊ Π΄Π΅ΡΠΈΡΠΈΡΡ Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π ΠΠ‘ Π½Π° ΡΠΎΠ½Π΅ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠΏΡΠΎΠ»ΠΈΠ½Π°, ΡΡΠΎ ΠΌΠΎΠΆΠ΅Ρ ΡΠ²Π»ΡΡΡΡΡ ΡΠ²ΡΠ·ΡΡΡΠΈΠΌ Π·Π²Π΅Π½ΠΎΠΌ ΠΌΠ΅ΠΆΠ΄Ρ Π°ΡΡΠΈΠ·ΠΌΠΎΠΌ ΠΈ Π³ΠΈΠΏΠ΅ΡΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΡΡΡΡ ΡΡΡΡΠ°Π²ΠΎΠ². Π ΡΠ²ΠΎΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ, Π΄Π΅ΡΠΈΡΠΈΡ ΡΡΠ΄Π° Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ, ΡΠ²Π»ΡΡΡΠΈΡ
ΡΡ ΠΏΡΠ΅ΠΊΡΡΡΠΎΡΠ°ΠΌΠΈ Π½Π΅ΠΉΡΠΎΠΌΠ΅Π΄ΠΈΠ°ΡΠΎΡΠΎΠ², ΠΌΠΎΠΆΠ΅Ρ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡΡ ΠΊ ΡΡΡΠ³ΡΠ±Π»Π΅Π½ΠΈΡ Π½Π΅ΡΠ²Π½ΠΎ-ΠΏΡΠΈΡ
ΠΈΡΠ΅ΡΠΊΠΈΡ
Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ. Π ΡΡΠΎΠΉ ΡΠ²ΡΠ·ΠΈ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΡ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ ΠΌΠΎΠΆΠ΅Ρ ΡΠ²Π»ΡΡΡΡΡ ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ
Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΉ Π² ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π ΠΠ‘