Expression of p63, TTF–1 and Maspin in non-small cell lung carcinoma and their effect on the prognosis and differential diagnosis [Küçük hücreli dişi akciğer karsinomunda p63, TTF-1 ve maspin ekspresyonu - Prognoz ve ayırıcı tanı üzerine etkileri]

PubMed ID: 26456962Objective: Lung cancer is still the leading cause of cancer mortality. Antiapoptotic genes and protease inhibitors play an important role in the development of lung cancer. Material and Method: p63, TTF-1 and maspin expression and their role in the differential diagnosis, overall survival, progression-free survival and other clinicopathological characteristics of the patients were investigated in 80 surgically-resected non-small cell lung carcinomas. Results: The maximal tumor diameter range was 1.5–11 cm (mean: 4.06±1.8 cm). Forty-five (56.3%) tumors were adenocarcinoma, 23 (28.8%) squamous cell carcinoma, four (5%) large cell carcinoma, six (7.5%) large cell neuroendocrine carcinoma, one (1.2%) sarcomatoid carcinoma while one was (1.2%) both adenocarcinoma and squamous cell carcinoma. The patients with advanced TNM stage and a tumor diameter more than 3 cm had markedly poor survival. Immunohistochemically, p63 staining was present in 87.5% of squamous cell carcinomas, 4.3% of adenocarcinomas, 25% of large cell carcinomas, and 16.7% of large cell neuroendocrine carcinomas. Similarly, maspin was positive in 66.7% of squamous cell carcinomas and 17.4% of adenocarcinomas. The TTF–1 staining rate was higher in adenocarcinomas (84.8%). There was no immunoreactivity in squamous cell carcinomas (p0.05) while maspin has a negative prognostic effect in adenocarcinoma (p=0.048). Conclusion: This study suggests that p63 and TTF–1 are reliable markers in non-small cell lung carcinoma and can be used in differential diagnosis. Maspin has been identified as a prognostic marker in adenocarcinoma. However, more studies are required to elucidate the significance of maspin. © 2015, Federation of Turkish Pathology Societies. All rights reserved

The effect of short-term pulmonary rehabilitation on pulmonary function tests, blood gases, functional capacity, dyspnea, quality of life and psychological symptoms in chronic pulmonary diseases: A retrospective study [Kronik Pulmoner Hastali{dotless}klarda Ki{dotless}sa Dönem Pulmoner Rehabilitasyonun Pulmoner Fonksiyon Testleri, Kan Gazi{dotless}, Fonksiyonel Kapasite, Dispne, Yaşam Kalitesi ve Psikolojik Semptomlar Üzerine Etkisi: Retrospektif Çali{dotless}şma]

Objective: To establish the efficacy of short-term outpatient pulmonary rehabilitation in patients with chronic pulmonary diseases. Materials and Methods: Data from 65 outpatients [Chronic Obstructive Pulmonary Disease (COPD, Group 1, n=44) and non-COPD (Group 2, n=21)] who presented to the rehabilitation center were analyzed retrospectively. Respiratory functions, blood gases, functional capacity (peak oxygen consumption (pVO2), shuttle walk test (SWT), endurance shuttle walk test (ESWT), dyspnea [Medical Research Council (MRC) Dyspnea Scale], quality of life (Saint George's Respiratory Questionnaire, SGRQ), and psychological symptoms (Hospital Anxiety and Depression Scale, HADS) tests before and after an 8-week rehabilitation program were obtained from patients' medical records. Results: After the rehabilitation program, a significant improvement in pVO2, ESWT, SGRQ (symptom, activity, impact subscale and the total score), and MRC dyspnea scale (p<0.05) was observed in both groups, compared to the pre-rehabilitation period. In contrast, no significant improvement was observed in either groups following the rehabilitation program with respect to respiratory function tests (ZEV1 (ml,%), ZVK (ml,%), ZEV1/ZVK (%), blood gas measurements (paO2, paCO2, oxygen saturation), SWT, and HADS (p>0.05). On the other hand, in inter-group comparison, the significant low values of ZEV1 and ZEV1/ZVK in the pre-rehabilitation period in Group 1 compared to Group 2, also persisted after rehabilitation (p<0.05). The comparisons regarding the rest of parameters did not reveal any significant difference (p>0.05). Conclusion: Outpatient pulmonary rehabilitation improves functional capacity, dyspnea, and quality of life in patients with COPD and non-COPD. Whatever the dyspnea etiology was, a regular exercise program in the rehabilitation unit is recommended for patients with chronic pulmonary diseases. Turk J Phys Med Rehab 2010;56:6-10. © Turkish Journal of Physical Medicine and Rehabilitation, Published by Galenos Publishing. All rights reserved

A comparison of two endoscopic posterior cordotomy techniques: Laser cordotomy vs diathermy-assisted cordotomy

WOS: 000423208500031PubMed ID: 28800194Objectives: To compare respiratory function, swallowing and voice quality of bilateral abductor vocal fold paralysis (BAVFP) patients undergoing laser and diathermyassisted posterior cordotomy. Design: Prospective study. Setting: Tertiary academic hospital. Participants: Thirty patients were included in the study (groups 1 and 2, 15 patients each). Mean age was 53 +/- 14.27 years with a range of 31-78 years (12 [40%] males, 18 [60%] females). Main outcome measures: Sufficient airway, complications, FEV1, FEV1/FVC, peak expiratory flow rate (PEF), voice quality VAS, fundamental frequency, jitter, shimmer, NHR, amplitude perturbation quotient (APQ) and pitch perturbation quotient (PPQ) scores. Results: A sufficient laryngeal airway was achieved in all patients. Six patients (20%) developed postoperative granulation tissue (2 in group 1 and 4 in group 2). There was a statistically significant improvement in FEV1, FEV1/FVC and PEF measurements at the postoperative sixth month compared to preoperative measurements in both of the groups (P .05). Conclusions: Laser and diathermy-assisted posterior cordotomy are both minimally invasive, effective techniques with a long-term sufficient laryngeal airway. Despite lower quality of voice VAS scores, objective acoustic outcomes were not significantly lower in both of the groups

Experience of Reduced Dose Alteplase in Patients with Pulmonary Embolism Intermediate-High-Risk: A Single Centre Study

International Conference of the American-Thoracic-Society -- MAY 13-18, 2022 -- San Francisco, CA[No Abstract Available]Amer Thorac So

Risk Factors for Ventilator-Associated Pneumonia Caused by MRSA in a Respiratory Intensive Care Unit

International Conference of the American-Thoracic-Society -- 2020 -- ELECTR NETWORKWOS: 000556393501527[No abstract available]Amer Thorac So