Bioactive Seed Plants Database of Turkey

Objective: To date, many studies have been conducted on the chemical content and bioactivity of seed plants and are still being conducted. However, these studies are scattered in different access sources and therefore access to information may be late or incomplete. Therefore, in this study, we performed literature on seed plants of the Flora of Turkey of the research bioactivity containing information as can be queried remotely accessible, systematic storage of information by creating a database of Turkish and English and is intended to ensure that information. Material and Method: At the first stage of the study, bioactivity studies conducted on seed plants of the Flora of Turkey and published between 1928-2018 were accessed, deciphered and a bibliography was prepared. In the second stage of the study, a web-based database management system was developed in order to transfer the information contained in the content of bioactivity studies, the literature was obtained, and its contents were recorded in the database. Finally, the analysis of the contents recorded in the database was carried out. Result and Discussion: As a result of the scans, 1307 literature was included in the bibliography, while 1088 of them were found suitable for registration in the database, and a total of 49.486 lines of data were entered. When the data were examined in detail, it was seen that bioactivity studies of 430 genera and 1594 taxa belonging to 107 families were recorded. The families with the most taxa were determined as Lamiaceae (307 taxa), Asteraceae (271 taxa) and Fabaceae (125 taxa). 115 different activities were recorded in the database. The largest number of taxa; antimicrobial activity (962 taxa), antioxidant activity (950 taxa), cytotoxic activity (220 taxa), anti-inflammatory activity (160 taxa) and analgesic-Antinociceptive activity (113 taxa) are investigated in terms of. The species with the most bioactivity studies were determined as Urtica dioica (18 activities), Hypericum perforatum (17 activities) and Cistus laurifolius (16 activities). When the locality records were examined, it was determined that the most taxa were obtained from the Central Anatolia Region and the least taxa were obtained from the Southeastern Anatolia Region. © 2023 University of Ankara. All rights reserved

Aurora kinase A (AURKA) and never in mitosis gene A-related kinase 6 (NEK6) genes are upregulated in erosive esophagitis and esophageal adenocarcinoma

Gastroesophageal reflux disease is a risk factor for esophageal adenocarcinoma yet studies that have investigated the relationship between erosive esophagitis and esophageal adenocarcinoma have usually focused on symptom-related evidence or polymorphisms. There are no epigenetic gene expression studies on this topic. In this study, we aimed to evaluate the relationship between erosive esophagitis and esophageal adenocarcinoma to identify whether there is a genetic predisposition for esophageal adenocarcinoma. The Human Epigenetic Chromatin Modification Enzyme RT 2 Profiler™ PCR array (PAHS-085A) was used to detect the expression of 84 key genes encoding enzymes. This was carried out prospectively for samples from 60 patients (20 patients as a control group, 20 patients with erosive esophagitis and 20 patients with esophageal adenocarcinoma). AURKA, AURKB, NEK6 were expressed at significantly higher levels in esophageal adenocarcinoma compared to the control group. MBD2 was expressed at significantly lower levels in the esophageal adenocarcinoma group compared to the control group. AURKA, AURKC, HDAC9 and NEK6 were expressed at significantly higher levels in erosive esophagitis compared to the control group. There was no difference in upregulated gene expression between the erosive esophagitis and esophageal adenocarcinoma. MBD2 was significantly downregulated in esophageal adenocarcinoma compared to erosive esophagitis. NEK6 and AURKA were significantly upregulated in esophageal adenocarcinoma and erosive esophagitis compared to the control group. This is a novel study on the genetic predisposition for erosive esophagitis and esophageal adenocarcinoma. AURKA and NEK6 are two promising genetic markers for erosive esophagitis and esophageal adenocarcinoma