ADRIA LITHOSPHERE INVESTIGATION ALPHA - Cruise No. M86/3, January 20 - February 04, 2012, Brindisi (Italy) - Dubrovnik (Croatia)

The Adriatic Sea and underlying lithosphere remains the least investigated part of the Mediterranean Sea. To shed light on the plate tectonic setting in this central part of southern Europe, R/V METEOR cruise M86/3 set out to acquire deep penetrating seismic data in the Adriatic Sea. M86/3 formed the core of an amphibious investigation crossing Adria from the Italian Peninsula into Montenegro/Albania. A total of 111 OBS/OBH deployments were successfully carried out, in addition to 47 landstations both in Italy and Montenegro/Albania, which recorded the offshore airgun shots. In the scope of this shoreline-crossing study, the aim is to quantify the shallow geometry, deep boundaries and the architecture of the southern Adriatic crust and lithosphere and to provide insights on a possible decoupling zone between the northern and southern Adriatic domains. Investigating the structure of the Adriatic crust and lithospheric mantle and analyzing the tectonic activity are essential for understanding the mountain-building processes that underlie the neotectonics and earthquake hazard of the Periadriatic region, especially in the vicinity of local decoupling zones

IgG Fc N-glycosylation translates MHCII haplotype into autoimmune skin disease

The major histocompatibility complex haplotype represents the most prevalent genetic risk factor for the development of autoimmune diseases. However, the mechanisms by which major histocompatibility complex-associated genetic susceptibility translates into autoimmune disease are not fully understood. Epidermolysis bullosa acquisita is an autoimmune skin-blistering disease driven by autoantibodies to type VII collagen. Here, we investigated autoantigen-specific plasma cells, CD4(+) T cells, and IgG fraction crystallizable glycosylation in murine epidermolysis bullosa acquisita in congenic mouse strains with the disease-permitting H2s or disease-nonpermitting H2b major histocompatibility complex II haplotypes. Mice with an H2s haplotype showed increased numbers of autoreactive CD4(+) T cells and elevated IL-21 and IFN-gamma production, associated with a higher frequency of IgG autoantibodies with an agalactosylated, proinflammatory N-glycan moiety. Mechanistically, we show that the altered antibody glycosylation leads to increased ROS release from neutrophils, the main drivers of autoimmune inflammation in this model. These results indicate that major histocompatibility complex II-associated susceptibility to autoimmune diseases acuminates in a proinflammatory IgG fraction crystallizable N-glycosylation pattern and provide a mechanistic link to increased ROS release by neutrophils.Proteomic

ADAMDEC1 maintains a growth factor signaling loop in cancer stem cells

Glioblastomas (GBM) are lethal brain tumors where poor outcome is attributed to cellular heterogeneity, therapeutic resistance, and a highly infiltrative nature. These characteristics are preferentially linked to GBM cancer stem cells (GSCs), but how GSCs maintain their stemness is incompletely understood and the subject of intense investigation. Here, we identify a novel signaling loop that induces and maintains GSCs consisting of an atypical metalloproteinase, a disintegrin and metalloproteinase domain-like protein decysin 1 (ADAMDEC1), secreted by GSCs. ADAMDEC1 rapidly solubilizes fibroblast growth factor-2 (FGF2) to stimulate FGF receptor 1 (FGFR1) expressed on GSCs. FGFR1 signaling induces upregulation of Zinc-finger E-box-binding homeobox 1 (ZEB1) via ERK1/2 that regulates ADAMDEC1 expression through miR-203, creating a positive feedback loop. Genetic or pharmacological targeting of components of this axis attenuates self-renewal and tumor growth. These findings reveal a new signaling axis for GSC maintenance and highlight ADAMDEC1 and FGFR1 as potential therapeutic targets in GB

Record of fluvial and biogenic sedimentation processes in sediments of the Lower Vistula Valley floor

W artykule przedstawiono przegląd osadów powodziowych i biogenicznych zdeponowanych w dnie Doliny Dolnej Wisły od okolic Górska, w środkowej części Kotliny Toruńskiej, po okolice Grudziądza. Omówiono piaszczyste osady powodziowe, osady basenów popowodziowych i mineralne osady jeziorzysk dolinnych. Dokonano analizy podstawowych własności utworów biogenicznych i ich interpretacji genetycznej. Omówiono też wyniki badań nad rekonstrukcją układu koryta Wisły w ciągu ostatnich 200 lat w Kotlinie Grudziądzkiej i Basenie Unisławskim oraz problem powolnego zamulania starorzeczy powstałych przed regulacją i po regulacji hydrotechnicznej w końcu XIX w. Wyjaśniono kwestię gradientu zawartości węglanowej materii rozpuszczonej w dnie doliny i jego wpływ na sedymentację osadów. Zwrócono uwagę na podobieństwa i różnice w transporcie materii rozpuszczonej i zawieszonej między korytem Wisły i starorzeczami na przykładzie starorzecza Starej Wisły i koryta Wisły w Bratwinie.The paper is a review of flood and biogenic sediments which have been deposited on the Lower Vistula Valley floor from the vicinity of Górsk to Grudziądz town. Sandy flood sediments, flood basin sediments and mineral infillings of former back swamps are described. Biogenic sediments are also discussed and genetically interpreted. The results of the Vistula channel reconstruction in Grudziądz Basin and Unisław Basin in the last 200 years are also presented. The reconstruction is strongly linked with the problem of relatively slow siltation of oxbows after the hydrotechnical regulation at the end of XIX-th century. The question of the carbonates gradient in floodplain sediments is also explained. The differences and similarities of the dissolved and suspended matter transport between the main channel and fluvial lake is shown on the example of the oxbow lake and Vistula river channel in Bratwin

Characteristics of depositional environments of Czechowskie Lake basin and its vicinity

W artykule przedstawiono przegląd badań nad morfogenezą misy jeziornej Jeziora Czechowskiego na Pojezierzu Starogardzkim. W dostępnych odsłonięciach, wkopach i wierceniach o nienaruszonej strukturze przeprowadzono analizę sedymentologiczną osadów glacjofluwialnych, glacjolimnicznych, limnicznych i stokowych. Wyniki tej analizy uzupełniono rezultatami kartowania geologicznego i geomorfologicznego. W efekcie przeprowadzonych prac stwierdzono, że misa jeziora założona jest w głębokiej rynnie subglacjalnej, która do początku allerødu zakonserwowana była bryłami martwego lodu. Ich wytopienie doprowadziło do powstania zróżnicowanej morfologii dna rynny. W najgłębszych miejscach, dzięki ograniczonej miksji, były warunki do zachowania rocznej laminacji osadów dennych. Sedymentacja osadów glacjofluwialnych w otoczeniu rynny była bardzo zróżnicowana i w wielu miejscach wskazuje na warunki przepływu nadkrytycznego. W przypowierzchniowej warstwie osadów sandrowych stwierdzono ślady zapisu procesów mrozowych (gleby mrozowe) oraz wytrącenia węglanowe wskazujące na występowanie warunków peryglacjalnych po zaprzestaniu przepływu proglacjalnego. Osady limniczne są również zróżnicowane w zależności od cech morfometrycznych basenu sedymentacyjnego, a przede wszystkim od głębokości ich depozycji. Osady stokowe pochodzą w większości z ostatnich dwustu lat, a ich depozycja nastąpiła wskutek działalności gospodarczej człowieka.The paper aims to review the investigations on the genesis of the Czechowskie Lake basin (Starogard Lakeland, north-central Poland). The sedimentological analysis of the glaciofluvial, glaciolimnic, limnic and colluvial deposits have been conducted in the outcrops, pits and boreholes with undisturbed cores. They were supplemented by the results of the geological and geomorphological mapping. Summing up the investigations it can be stated that the lake basin developed within a deep subglacial channel which was preserved by the dead ice blocks till the onset of the Allerød. Their melting led to the emergence of a morphologically diversified lake basin. The conditions in its deepest parts, due to hampered mixing and wave action, favoured the preservation of the annually laminated sediments. The glaciofluvial deposition in the vicinity of the lake was diverse and in many places it indicates the supercritical condition of the water flow. Within the near-surface layer of outwash deposits were recognized the traces of the periglacial processes and calcareous precipitates which indicate short glaciolimnic periods or breaks in sedimentation. The limnic sediments are also diversified and dependent on the morphometric features of the sedimentary basin, mostly the depth of the deposition. Colluvial deposits have originated mostly in the last 200 years as a consequence of the transient deforestation of the surrounding area