DOES ROUTINE PATHOLOGY EVALUATION OF UTERINE CONTENT FOLLOWING EVACUATION FOR ABNORMAL EARLY PREGNANCY INFLUENCE FURTHER MANAGEMENT?

U cilju utvrđivanja svrsishodnosti rutinske patohistološke analize kiretmana nakon evakuacije uterusa poradi poremećene rane trudnoće proveli smo retrospektivno istraživanje kojim su obuhvaćene sve pacijentice koje su, tijekom jednogodišnjeg razdoblja, nakon dijagnoze poremećene trudnoće u prvom tromjesečju, imale evakuaciju uterusa kiretažom. Od ukupno 335 bolesnica tijekom godine dana, 312 ih je imalo nalaz patohistološke analize te su uključene u konačnu analizu. U 272 (87,2 %) histopatološkom analizom potvrđeno je tkivo trofoblasta, dok u ostalih 40 (12,8 %) tkiva trofoblasta nije nađeno unatoč uputnoj dijagnozi. U 10 (3,2 %) ispitanica histopatološkom analizom postavljena je dijagnoza gestacijske trofoblastične bolesti na koju se nije sumnjalo prije evakuacije uterusa. Kod jedne je ispitanice (0,3 %) sumnja na gestacijsku trofoblastičnu bolest isključena histopatološkom analizom. Zaključno, rutinska patohistološka analiza kiretmana nakon evakuacije uterusa indicirane poremećenom ranom trudnoćom potencijalno utječe na daljnji tijek liječenja u 16,3 % ispitanica te je unatoč troškovima opravdana u rutinskoj kliničkoj praksi.The aim was to determine usefulness of routine pathologic evaluation of uterine content after uterine evacuation following the diagnosis of abnormal early pregnancy. This retrospective descriptive study performed during a one-year period included all patients diagnosed with abnormal early pregnancy clinically or by ultrasound in the fi rst trimester. All patients had uterine evacuation. During the study period, 335 women were diagnosed with abnormal early pregnancy and referred for uterine evacuation. Pathology results were available for 312 women included in the analysis. In 272 (87.2%) women, trophoblast tissue was found on examination and therefore intrauterine pregnancy was confi rmed. In the remaining 40 patients, trophoblast was not found. In 10 (3.2%) patients, gestational trophoblastic disease was diagnosed, not being suspected on pre-evacuation assessment. In one patient, suspected molar pregnancy was excluded by pathology evaluation. Based on 51/312 (16.3 %) patients where pathology examination of uterine content infl uenced further management and treatment, we believe that routine pathology examination of uterine content after uterine evacuation in the fi rst trimester following abnormal early pregnancy is justifi able in clinical practice

Contribution to diagnostics/prognostics of tuberculosis in children. I. New methods of assaying zinc and simultaneously copper and zinc in diluted sera by flame atomic-absorption spectrometry

In an attempt to provide a reliable status of metal ions in children, new methods of analysis of children's sera are proposed. New flame atomic-absorption spectrometric (FAAS) methods are simple, cost- and time-effective and, above all, labor-, reagent- and sample-saving. Two methods were suggested: method A for simultaneous determination of Cu and Zn from 5-fold diluted sera, and method B, for assaying zinc alone in 10-fold diluted samples. Both methods are based on a single-step sample pretreatment (deproteinization with 3 mol dm–3 HCl). Method A uses a single-step calibration with a mixed standard. The main advantage of method B is an additional reduction in sample consumption. Both methods were fully validated against reference methods. Accuracy, sensitivity and precision have proven them to be comparable to the reference methods in terms of analytical performance, and applicable to analyses of children's sera

Contribution to diagnostics/prognostics of tuberculosis in children. II. Indicative value of metal ions and biochemical parameters in serum

In an attempt to provide a reliable status of metal ions in children, new methods of analysis of children's sera are proposed. New flame atomic-absorption spectrometric (FAAS) methods are simple, cost- and time-effective and, above all, labor-, reagent- and sample-saving. Two methods were selected andvalidated against reference methods: method A for simultaneous determination of Cu and Zn from 5-fold diluted sera, and method B, for assaying zinc alone in 10-fold diluted samples. Both methods are based on a single-step sample pretreatment (deproteinization with 3 mol dm-3 HCl). Method A uses a single-step calibration with a mixed standard. The main advantage of method B is an additional reduction in sample consumption. Both methods were fully validated; accuracy, sensitivity and precision have proven them to becomparable to the reference methods, in terms of analytical performance,and applicable to analyses of children's sera

Simultaneous determination of iron and copper in children's sera by FAAS

Predložena je nova jednostavna metoda plamene atomsko-apsorpcijske spektrometrije (FAAS), za simultano određivanje željeza i bakra u serumu djece. Ona se temelji na predobradbi uzorka u jednom koraku (deproteinizacija s 3 mol L–3 HCl u odnosu 1:1) i kalibraciji u jednom koraku sa standardom pripravljenim u 1.5 mol L–3 HCl. Tijekom optimizacije metode primijenjen je multifaktorski dizajnirani eksperiment. Preporučena metoda osigurava ispravnost, osjetljivost i preciznost usporedljivu onima referentnih metoda. Novi je pristup jednostavan i brz; on štedi i vrijeme i reagense i uzorke, pri čemu je potonje posebno važno u dječjoj dijagnostici.A new and simple flame atomic-absorption spectrometric (FAAS) method is proposed for simultaneous determination of iron and copper in children's sera. It is based on single-step sample pretreatment (deproteinization with 3 mol L–1 HCl, ratio 1:1) and single-step calibration using 1.5 mol L–1 HCl standard. During method’s optimization a short multifactorial design experiment was used. The proposed method assures accuracy, sensitivity and precision comparable to that of the reference methods. The new approach is simple and time-, labour- and serum-saving, the latter being especially important in pediatric diagnostics

Databases and Information Systems in the AI Era: Contributions from ADBIS, TPDL and EDA 2020 Workshops and Doctoral Consortium

Research on database and information technologies has been rapidly evolving over the last couple of years. This evolution was lead by three major forces: Big Data, AI and Connected World that open the door to innovative research directions and challenges, yet exploiting four main areas: (i) computational and storage resource modeling and organization; (ii) new programming models, (iii) processing power and (iv) new applications that emerge related to health, environment, education, Cultural Heritage, Banking, etc. The 24th East-European Conference on Advances in Databases and Information Systems (ADBIS 2020), the 24th International Conference on Theory and Practice of Digital Libraries (TPDL 2020) and the 16th Workshop on Business Intelligence and Big Data (EDA 2020), held during August 25–27, 2020, at Lyon, France, and associated satellite events aimed at covering some emerging issues related to database and information system research in these areas. The aim of this paper is to present such events, their motivations, and topics of interest, as well as briefly outline the papers selected for presentations. The selected papers will then be included in the remainder of this volume

DOES ROUTINE PATHOLOGY EVALUATION OF UTERINE CONTENT FOLLOWING EVACUATION FOR ABNORMAL EARLY PREGNANCY INFLUENCE FURTHER MANAGEMENT?

U cilju utvrđivanja svrsishodnosti rutinske patohistološke analize kiretmana nakon evakuacije uterusa poradi poremećene rane trudnoće proveli smo retrospektivno istraživanje kojim su obuhvaćene sve pacijentice koje su, tijekom jednogodišnjeg razdoblja, nakon dijagnoze poremećene trudnoće u prvom tromjesečju, imale evakuaciju uterusa kiretažom. Od ukupno 335 bolesnica tijekom godine dana, 312 ih je imalo nalaz patohistološke analize te su uključene u konačnu analizu. U 272 (87,2 %) histopatološkom analizom potvrđeno je tkivo trofoblasta, dok u ostalih 40 (12,8 %) tkiva trofoblasta nije nađeno unatoč uputnoj dijagnozi. U 10 (3,2 %) ispitanica histopatološkom analizom postavljena je dijagnoza gestacijske trofoblastične bolesti na koju se nije sumnjalo prije evakuacije uterusa. Kod jedne je ispitanice (0,3 %) sumnja na gestacijsku trofoblastičnu bolest isključena histopatološkom analizom. Zaključno, rutinska patohistološka analiza kiretmana nakon evakuacije uterusa indicirane poremećenom ranom trudnoćom potencijalno utječe na daljnji tijek liječenja u 16,3 % ispitanica te je unatoč troškovima opravdana u rutinskoj kliničkoj praksi.The aim was to determine usefulness of routine pathologic evaluation of uterine content after uterine evacuation following the diagnosis of abnormal early pregnancy. This retrospective descriptive study performed during a one-year period included all patients diagnosed with abnormal early pregnancy clinically or by ultrasound in the fi rst trimester. All patients had uterine evacuation. During the study period, 335 women were diagnosed with abnormal early pregnancy and referred for uterine evacuation. Pathology results were available for 312 women included in the analysis. In 272 (87.2%) women, trophoblast tissue was found on examination and therefore intrauterine pregnancy was confi rmed. In the remaining 40 patients, trophoblast was not found. In 10 (3.2%) patients, gestational trophoblastic disease was diagnosed, not being suspected on pre-evacuation assessment. In one patient, suspected molar pregnancy was excluded by pathology evaluation. Based on 51/312 (16.3 %) patients where pathology examination of uterine content infl uenced further management and treatment, we believe that routine pathology examination of uterine content after uterine evacuation in the fi rst trimester following abnormal early pregnancy is justifi able in clinical practice

Contribution to diagnostics/prognostics of tuberculosis in children. I. New methods of assaying zinc and simultaneously copper and zinc in diluted sera by flame atomic-absorption spectrometry

In an attempt to provide a reliable status of metal ions in children, new methods of analysis of children’s sera are proposed. New flame atomic-absorption spectrometric (FAAS) methods are simple, cost- and time-effective and, above all, labor-, reagent- and sample-saving. Two methods were suggested: method A for simultaneous determination of Cu and Zn from 5-fold diluted sera, and method B, for assaying zinc alone in 10-fold diluted samples. Both methods are based on a single-step sample pretreatment (deproteinization with 3 mol dm–3 HCl). Method A uses a single-step calibration with a mixed standard. The main advantage of method B is an additional reduction in sample consumption. Both methods were fully validated against reference methods. Accuracy, sensitivity and precision have proven them to be comparable to the reference methods in terms of analytical performance, and applicable to analyses of children’s sera

Towards a Formal Specification of Production Processes Suitable for Automatic Execution

Technological advances and increasing customer need for highly customized products have triggered a fourth industrial revolution. A digital revolution in the manufacturing industry is enforced by introducing smart devices and knowledge bases to form intelligent manufacturing information systems. One of the goals of the digital revolution is to allow flexibility of smart factories by automating shop floor changes based on the changes in input production processes and ordered products. In order to make this possible, a formal language to describe production processes is needed, together with a code generator for its models and an engine to execute the code on smart devices. Existing process modeling languages are not usually tailored to model production processes, especially if models are needed for automatic code generation. In this paper we propose a research on Industry 4.0 manufacturing using a Domain-Specific Modeling Language (DSML) within a Model-Driven Software Development (MDSD) approach to model production processes. The models would be used to generate instructions to smart devices and human workers, and gather a feedback from them during the process execution. A pilot comparative analysis of three modeling languages that are commonly used for process modeling is given with the goal of identifying supported modeling concepts, good practices and usage patterns