Retrospective study of clinico-pathological features of ovarian tumors

Background: Ovarian masses are a frequent clinical diagnosis in general Gynecology. The aim of the present study was to assess risk factors, clinical features, CA 125 levels, histopathological diagnosis of the patients of all ovarian tumors that underwent surgical management between August 2013 to August 2017.Methods: This was the retrospective study conducted in the department of Obstetrics and Gynecology in MIMER Medical College. We studied 50 patients those who underwent surgical management. Most of the patients 56% were in the reproductive age group, 28% patients were in the perimenopausal age group, 14% were in the postmenopausal age group. 82% patients were parous.Results: Pain abdomen was most common symptom in 50% patients. Bilaterality of the tumor was common in malignant tumors. CA 125 was found to be increased more in malignant tumors. Most common co morbid condition was hypertension found in 12% patients. Most common ovarian tumor found was serous cystadenoma 34% and most common malignant tumors were serous cystadenoma carcinoma 16%.Conclusions: Out of all operated patients 11 (22%) were malignant, 37 (74%) were benign and 2 (%) were borderline tumors. Out of all malignant tumors 8 (72%) were serous cysadenocarcinoma. It is difficult to always differentiate between malignant and benign tumors clinically. Analysis of risk factors and protective factors, thorough abdomino-pelvicbimanual examination, certain features on radiological imaging, presence of ascites and bilaterality, CA125 levels, helps increasing the accuracy of the diagnosis

Literature Review on Secure Mining of Association Rules in Horizontally Distributed Databases

Data and knowledge Engineering is one of the area under data mining. Which can extract important knowledge from large database, but sometimes these database are divided among various parties. This paper addresses a fast distributed mining of association rules over horizontally distributed data. This paper presents different methods for secure mining of association rules in horizontally distributed databases. The main aim of this paper is protocol for secure mining of association rules in horizontally distributed databases. The current main protocol is that of Kantarcioglu and Clifton. This protocol, like theirs, is based on the Fast Distributed Mining (FDM) algorithm of Cheung et al., which is an unsecured distributed version of the Apriori algorithm. The main components in this protocol are two novel secure multi-party algorithms — one that computes the union of private subsets that each of the interacting players hold, and another that tests the inclusion of an element held by one player in a subset held by another. This protocol offers improved privacy with respect to the protocol in. In addition, it is simpler and is significantly more efficient in terms of communication rounds, communication cost and computational cost

Prevalence of thyroid dysfunction in pregnancy and its impact on maternal and fetal outcome: a prospective study in a tertiary care hospital in Maharashtra, India

Background: Thyroid dysfunction is the commonest endocrinological disorder in pregnancy. A broad spectrum of adverse outcomes in pregnant women and the fetus have been reported which can be prevented by early diagnosis and treatment of thyroid dysfunction. Thyroid dysfunction in pregnancy has not yet been extensively studied in India. Hence, this study was conducted for assessment of the prevalence of thyroid dysfunction in pregnancy and effect on the mother and her fetus.Methods: This study is a prospective study conducted in the department of obstetrics and gynecology, MIMER Medical College and Hospital, Talegaon Dabhade, Maharashtra. A 3 years study. Antenatal women attending the outpatient and inpatient department of the hospital. The total sample population comprised of 698 pregnant women with uncomplicated singleton intra-uterine pregnancy. All participants were screened by estimation for serum TSH in first trimester. Immediately after delivery the cord blood sample was collected and cord blood TSH levels were estimated. Babies, whose cord blood TSH levels were elevated, were called for follow-up on day 5 of neonatal life and TSH, free T3 and free T4 levels were estimated. Among these babies, those diagnosed with congenital hypothyroidism were started on appropriate treatment.Results: The prevalence of thyroid dysfunction in pregnancy in present study was 17.90% whereas 82.1% patients were euthyroid (control group). Among the 17.9% patients with thyroid dysfunction, 14.6% had subclinical hypothyroidism, 1.9% had overt hypothyroidism and 1.4% had hyperthyroidism.Conclusions: With this study, we can come to the conclusion that there is high prevalence of thyroid dysfunction in pregnancy. Thus, an early diagnosis and prevention of the aftermaths of thyroid dysfunction in pregnancy is of utmost importance

Prevalence of thyroid dysfunctions in pregnant women: a prospective study in a tertiary care hospital in Maharashtra, India

Background: Thyroid dysfunction is known to be the commonest endocrinological disorder in pregnancy. A range of adverse outcomes in pregnant women and the fetus have been reported. These can be prevented if the thyroid dysfunction is diagnosed and treated as early as possible. There are limited studies conducted on the prevalence of thyroid dysfunction in pregnancy in India. Hence, this study was conducted for assessment of the prevalence of thyroid dysfunction in pregnancy.Methods: The present study is a prospective study conducted in the Department of Obstetrics and Gynecology, MIMER Medical College and Hospital, Talegaon, Dabhade, Maharashtra. The total sample population comprised of 705 pregnant women with uncomplicated singleton intra-uterine pregnancy. All participants were screened by estimation for serum TSH in first trimester.Results: The prevalence of thyroid dysfunction in the present study is 13.9%. Of this, prevalence of hypothyroidism is 12.76% and that of hyperthyroidism is 1.13%.Conclusions: With this study, we conclude that there is high prevalence of thyroid dysfunction in pregnancy even in rural population. Thus, a universal screening helps in early diagnosis and preventing the aftermaths of thyroid dysfunction in pregnancy

<i>meta</i>-Selective olefination of fluoroarenes with alkynes using CO₂ as a traceless directing group.

From Europe PMC via Jisc Publications RouterHistory: ppub 2020-03-01, epub 2020-03-31Publication status: PublishedFunder: Engineering and Physical Sciences Research Council; Grant(s): EP/L014017/2Over the last few decades C-H olefination has received significant interest, due to the importance and usefulness of aryl olefins both as synthetic targets and intermediates. While a wide range of ortho-olefination protocols have been developed, only a small number of meta-olefinations are currently available. Importantly, the most common approach to meta-olefination, using a large meta-directing template, is not suitable for substrates such as fluorobenzenes, which cannot be derivatised. We report that the meta-selective olefination of fluoroarenes can be achieved via the use of CO2 as a traceless directing group, which can be easily installed and removed in a one-pot process. Furthermore, this approach avoids the use of stoichiometric Ag(i)-salts, commonly used in C-H olefinations, and affords complete meta- over ortho/para-regioselectivity

Outcome of external cephalic version (ECV) in singleton pregnancy with uncomplicated breech presentation at term in a tertiary rural hospital

Background: Breech presentation is the most common malpresentation. The incidence of breech presentation at term is 3-4%. Objective of present study was to evaluate the outcome of external cephalic version (ECV) in singleton pregnancy with uncomplicated breech presentation at term in tertiary rural hospital and to analyze the immediate and ultimate outcome of external cephalic version done in term pregnancy with breech presentation with gestational age ≥37 weeks.Methods: This study was conducted at MIMER Medical college and BSTR Hospital, Talegaon Dabhade. Patients with breech presentation at term were studied over duration of 2½ years. 50 patients with breech presentation ≥37 weeks fulfilling the inclusion criteria underwent External cephalic version (ECV). Further obstetric progress is studied with the perinatal outcome and results were analyzed.Results: ECV was successful in 66% cases, out of which 88% cases had vaginal delivery and 12 % cases had LSCS for obstetric indication. Perinatal outcome was not affected with ECV.Conclusions: ECV at term significantly reduces both the incidence of breech delivery and caesarean section rate for breech delivery. ECV does not adversely affect the maternal and perinatal outcome

Advancement in radiotherapy for head and neck cancer management: a review

Objective: This study aimed to evaluate the influence of side effects on the quality of life (QoL) and psychosocial functioning of patients with oropharyngeal cancer associated with Human Papillomavirus (HPV), and to explore de-escalation procedures in the treatment of head and neck cancer (HNC). Materials and Methods: This study relied on systematic reviews and original research and focused on younger and older patients with HPV-induced oropharyngeal squamous cell carcinoma (OPSCC) undergoing modern radiotherapy (RT). This study aimed to analyze the impact of side effects on QoL and psychosocial functioning in these patients. De-escalation procedures and their effectiveness in the treatment of HPV-induced OPSCC were investigated. This study examined sophisticated image guidance, adaptive therapies, and precise delivery methods of modern RT. Results: According to the findings, the side effects of modern RT in patients with HPV-induced OPSCC had a significant impact on their QoL and psychosocial functioning. Although the evidence regarding de-escalation procedures is still evolving, it suggests potential benefits in terms of reducing side effects and improving outcomes. The combination of modernization of RT, innovative systemic agents, and expanding therapeutic indications in the recurrent/metastatic context is also promising. Conclusions: Patients with HPV-induced OPSCC undergoing modern RT face considerable challenges related to side effects that affect their QoL and psychosocial well-being. Therefore, exploring de-escalation procedures to mitigate these issues and to improve treatment outcomes is crucial. Further research is required to establish conclusive evidence regarding the effectiveness of de-escalation procedures and the optimal treatment approaches for HPV-induced OPSCC. Additionally, integrating RT modernization, innovative systemic agents, and expanding therapeutic indications holds great potential for advancing HNC treatment in recurrent/metastatic settings

An RFI Detection Algorithm for Microwave Radiometers Using Sparse Component Analysis

Radio Frequency Interference (RFI) is a threat to passive microwave measurements and if undetected, can corrupt science retrievals. The sparse component analysis (SCA) for blind source separation has been investigated to detect RFI in microwave radiometer data. Various techniques using SCA have been simulated to determine detection performance with continuous wave (CW) RFI