ANTIDIABETIC AND ANTIOXIDANT ACTIVITY OF RESVERATROL AND VITAMIN-C COMBINATION ON STREPTOZOTOCIN INDUCED DIABETIC RATS

Objective: Resveratrol and vitamin-C combination was evaluated for its antidiabetic and antioxidant activity in streptozotocin (STZ) induced diabetic rats. Methods: The wistar rats were challenged with a single intra peritoneal injection of STZ (50 mg/kg). The rats were treated with graded oral dose of 10 mg/kg of resveratrol and 0.9 g/kg of Vitamin C for 21 days. The fasting blood glucose levels were monitored for all animals in 1,7,14 and 21 days of drug treatments by using glucometer. The liver homogenate was used for estimation of proteins, malondialdehyde (MDA), lipid hydroperoxide (LH), Super Oxide Dismutase (SOD), Catalase (CAT), Glutathione reductase (GSSH) and Reduced glutathione (GSH).Results: Resveratrol with vitamin C combination showed significant (P<0.01) increase in body weight, total protein, and significant (P<0.01) decrease in fasting blood sugar level, MDA and LH, when compared to diabetic control. Resveratrol and vitamin C significantly (P<0.01) restored the levels of both enzymatic (SOD, CAT, GSSH) and non enzymatic antioxidant enzymes (GSH) which are almost similar to the control.Conclusion: Resveratrol and vitamin C both is having antioxidant activity, but the combination showed synergistic antioxidant & antidiabetic activity. Thus, the present study provides a significant rationale for the management of diabetes.Â

ADVERSE EFFECTS AND SIDE EFFECTS ON VITAMIN THERAPY: A REVIEW

Vitamins are essential to our day to day life. Its shortage in our body can cause many disorders, decreased enzyme activities also affects the genetic factors. Vitamins should be supplied through the diet in the required amount. If it is not supplied properly, vitamin tablets will be prescribed. And also vitamin tablets are the co-medication for therapies like anticancer, anti tubercular, anti viral anti HIV treatments. Many news papers reported that vitamin therapies are causing major health problems like nephro/ urolithiasis, it can increases mortality rates in smokers by increasing the risk of lung cancer, it can cause abortion when it is taken during pregnancy. Thus here we reviewed the adverse effects of vitamin therapy from various reported cases, books, instructions provided from various health organizations and also news papers and magazines. It can help health professionals to control and monitor the vitamin therapies and make awareness about the adverse effects and possible side effects of regular vitamin uptake to society