Airy Bloom

This dress was created to increase awareness of the global air pollution issue and to emphasize our cooperative efforts to better the air quality. The abandoned air filters were recycled and rebirthed to create an elegant, romantic, and energetic dress. Just like combining people’s hopes and efforts one by one, the small pieces were connected to create a hopeful, blooming dress. The interesting textures of the air filters encompasses the airy, lightweight dress, and delivers the hopeful message. The dress was made through sustainable construction methods such as zero wastes. This design explored a new material, air filters, recreated into interesting textures. A special construction method was utilized to make the dress using the new material

Sustainable Fashion: Transformable Outerwear and Shopping Orientation

The purpose of this research was to investigate preferences and expectations for transformable outerwear and the differences between them based on consumers\u27 characteristics, including shopping orientations. The data were collected online with 273 U.S. consumers, who were asked about their shopping orientation, consumption behavior toward socially responsible apparel, preferences about transformable design options for outerwear, expected benefits, and expectations for transformable garments for sustainability. Using SPSS 23.0, the data were analyzed through descriptive analysis, Cronbach\u27s alpha, k-means cluster analysis, and a series of independent samples t-tests. These results are expected to be beneficial for designers and manufactures that are in the process of developing transformable clothing for sustainability

On cryptographic parameters of permutation polynomials of the form xrh(x(q−1)/d)x^rh(x^{(q-1)/d})

The differential uniformity, the boomerang uniformity, and the extended Walsh spectrum etc are important parameters to evaluate the security of S(substitution)-box. In this paper, we introduce efficient formulas to compute these cryptographic parameters of permutation polynomials of the form $x^rh(x^{(q-1)/d})$ over a finite field of $q=2^n$ elements, where $r$ is a positive integer and $d$ is a positive divisor of $q-1$. The computational cost of those formulas is proportional to $d$. We investigate differentially 4-uniform permutation polynomials of the form $x^rh(x^{(q-1)/3})$ and compute the boomerang spectrum and the extended Walsh spectrum of them using the suggested formulas when $4\le n\le 10$ is even, where $d=3$ is the smallest nontrivial $d$ for even $n$. We also investigate the differential uniformity of some permutation polynomials introduced in some recent papers for the case $d=2^{n/2}+1

Neuropathological changes in dorsal root ganglia induced by pyridoxine in dogs

Pyridoxine (PDX; vitamin B6), is an essential vitamin. PDX deficiency induces various symptoms, and when PDX is misused it acts as a neurotoxicant, inducing severe sensory neuropathy. To assess the possibility of creating a reversible sensory neuropathy model using dogs, 150 mg/kg of PDX was injected subcutaneously into dogs for 7 days and body weight measurements, postural reaction assessments, and electrophysiological recordings were obtained. In addition, the morphology of dorsal root ganglia (DRG) and changes in glial fibrillary acidic protein (GFAP) immunoreactive satellite glial cells and ionized calcium-binding adapter molecule 1 (Iba-1) immunoreactive microglia/macrophages were assessed at 1 day, 1 week, and 4 weeks after the last PDX treatment. During the administration period, body weight and proprioceptive losses occurred. One day after the last PDX treatment, electrophysiological recordings showed the absence of the H-reflex in the treated dogs. These phenomena persisted over the four post-treatment weeks, with the exception of body weight which recovered to the pre-treatment level. Staining (CV and HE) results revealed significant losses of large-sized neurons in the DRG at 1 day and 1 week after PDX treatment cessation, but the losses were recovered at 4 weeks post-treatment. The Iba-1 and GFAP immunohistochemistry results showed pronounced increases in reactive microglia/macrophage and satellite glial cell at 1 day and 1 week, respectively, after the last PDX treatment, and thereafter, immunoreactivity decreased with increasing time after PDX treatment. The results suggest that PDX-induced neuropathy is reversible in dogs; thus, dogs can be considered a good experimental model for research on neuropathy.This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Sci‑ ence, ICT & Future Planning (NRF-2017R1A1A1A05000762). The funding body played no role in the design and interpretation of the experiments. The found‑ ing sponsors had no role in the study design, performance, data collection and analysis, decision to publish, or preparation/writing of the manuscript

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

SummaryPolycythemia vera (PV), essential thrombocythemia (ET), and myeloid metaplasia with myelofibrosis (MMM) are clonal disorders arising from hematopoietic progenitors. An internet-based protocol was used to collect clinical information and biological specimens from patients with these diseases. High-throughput DNA resequencing identified a recurrent somatic missense mutation JAK2V617F in granulocyte DNA samples of 121 of 164 PV patients, of which 41 had homozygous and 80 had heterozygous mutations. Molecular and cytogenetic analyses demonstrated that homozygous mutations were due to duplication of the mutant allele. JAK2V617F was also identified in granulocyte DNA samples from 37 of 115 ET and 16 of 46 MMM patients, but was not observed in 269 normal individuals. In vitro analysis demonstrated that JAK2V617F is a constitutively active tyrosine kinase

The role of caudal genes in adult hematopoiesis and leukemogenesis

Caudal (Cdx) genes encode homeobox transcription factors that regulate Hox gene expression. There are three mammalian Cdx genes: Cdx1, Cdx2 and Cdx4. Cdx genes have been shown to be involved in embryonic hematopoiesis in zebrafish and murine embryonic stem cells. CDX genes have also been implicated in human hematopoietic malignancies. CDX2 is upregulated in most AML patients and overexpression of Cdx in murine models causes AML. Here, we investigated the normal function of Cdx in adult mammalian hematopoiesis and their interactions with known leukemic oncogenes MLL-AF9 and BCR-ABL using Cdx-deficient genetic mouse models. We characterized the hematopoietic system of Cdx4 germline and conditional knockout mice and Cdx1 germline knockout mice. We unexpectedly demonstrated that neither Cdx4 nor Cdx1 is essential for normal adult hematopoiesis in vivo. Cdx deficient mice had minimal hematopoietic defects and their hematopoietic stem cells possessed normal repopulating capabilities. Similar results were observed in the double Cdx1/4 mutants, confirming that the loss of Cdx1 and Cdx4 are dispensable for adult mammalian hematopoiesis. We went on to test whether Cdx4 is necessary for the development of MLL leukemia using a retroviral murine bone marrow transplantation model. We found that the loss of Cdx4 resulted in delayed latency of MLL-AF9 leukemia but was dispensable for leukemia induction. However, the phenotype of the resultant disease in the Cdx4-/- background was altered, with increased expression of lymphoid markers in primary recipients and the development of lymphoid leukemias in half of the secondary recipients. These results suggest a role for Cdx4 in MLL-induced leukemogenesis but it is not necessary for induction of MLL disease. Finally, we tested whether Cdx genes are necessary for the development of BCR-ABL leukemia. The abrogation of Cdx1 expression by shRNA hairpins decreased proliferation in BCR-ABL cell lines. Using a retroviral bone marrow transplantation model, we found that the combined loss of Cdx1 and Cdx4 effectively reduced the development of BCR-ABL leukemia. However, there were no differences in disease latency or penetrance with Cdx1-/-, Cdx4-/- or Cdx1+/-4-/-, suggesting functional redundancy among Cdx factors in the context of leukemogenesis

Explorations of wearable technology for tracking self and others

Abstract The purpose of this research is to explore designs and functions people like to have in wearable trackers and how these differ between novice and experienced users. Interviews were conducted with 20 people, consisted of novice and experienced users living in the US, by asking preferred designs and functions of wearable trackers for oneself and others, preferences on sharing the tracked data, and suggestions in designs and functions of wearables. The data were analyzed qualitatively. It is recommended to make wearable trackers as accessory types that are small, lightweight, and neutral colored. Wearable trackers can offer self-tracking of moods and feelings for novice users and self-track physical activities for experienced users. Novice users are more likely to track others’ physical health and experienced users preferred to track social media posts of others. Experienced users more reluctant to share their data with others than novice users. The results of this research will be helpful for designers, engineers, and marketers in the process of designing wearable technology

Wearable Technology in Fashion

As smart clothing is being increasingly recognized as a strong contender in future wearables, with its flexible and comfortable interface becoming more accessible to people, fashion also has been successfully orienting itself as the next game-changer in wearable technology through its connection to a wide range of design, lifestyle, and functionality with its scalability. This chapter introduces the currently available wearables in the fashion industry for varied symbolic, aesthetic, cultural, or functional purposes and the projects concerning smart clothing and soft wearable robot for future living with the enhanced comfort of the wearer. The chapter also discusses the future of wearable technology in the fashion industry.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Emerging Material