Η ιδέα της ιδιοκτησίας επί του εαυτού: μια φιλοσοφική ανασκευή

Συνοψίζοντας την παρούσα, σκοπός της ήταν να αναδειχθεί η ακαταλληλότητα της ιδέας της ιδιοκτησίας επί του εαυτού να προτάξει την ισότιμη ουσιαστική αυτονομία και να μας αντιμετωπίσει ως αυτοσκοπό, κυρίως λόγω των απαράδεκτων για το status μας, ως απαραβίαστου, βιοηθικών συνεπειών της. Εκτός από την παρουσίαση της λοκιανής θεμελίωσής της επί της εργασιακής θεωρίας, ως δικαιολογητικού λόγου της ατομικής ιδιοκτησίας, εκτέθηκε η σημασία της αρνητικής πλευράς της ιδιοκτησίας επί του εαυτού - όπως αυτή εντάσσεται στην φιλοσοφική θεωρία της ελευθεριοκρατίας και ειδικότερα της νοζικιανής - η οποία εξασφαλίζει την προστασία από τον εξαναγκασμό και τις προσβολές της σωματικής ακεραιότητας. Τα επιχειρήματα κατά της ιδιοκτησίας επί του εαυτού στηρίχθηκαν στις προσεγγίσεις των Cohen, Attas και Brenkert, και από τα οποία καταδείχθηκε η μη αναγκαιότητα και ανεπάρκειά της για την εξασφάλιση των δικαιωμάτων ελέγχου επί του εαυτού, του σώματος και των δυνάμεών μας. Τέλος, δικαιολογήθηκε η ασυμβατότητα της καθηκοντολογικής καντιανής αρχής με την ιδιοκτησία επί του εαυτού λόγω της θετικής πλευράς της, η οποία παρέχει στον ιδιοκτήτη επί του εαυτού εξουσίες όμοιες με αυτές ενός ιδιοκτήτη αντικειμένου, καταλήγοντας έτσι να αναιρεί τον αρχικά προστατευτικό της πυρήνα.Summarizing the present paper, its purpose was to highlight the unsuitability of the idea of self-ownership, in regards to promoting equal substantial autonomy and viewing us as an end in itself, mainly because of its unacceptable bioethical consequences regarding our inviolable status. Apart from using Locke's views on labor theory as a justification of private property, the importance of the negative aspect of self-ownership was also presented - as embodied in the philosophical theory of libertarianism, and in particular in the views of Nozik - which guarantees the protection from coercion and physical injuries. The arguments against self-ownership have been based on the Cohen, Attas, and Brenkert approaches, demonstrating its unnecessity and inadequacy to secure control rights over ourselves, our body and our powers. Finally, the incompatibility of the Kantian principle with self-ownership was justified because of its positive aspect, which gives the self-owner powers similar to those of an object owner, thus negating its original protective principle

AN INVESTIGATION OF THE IMPACT OF SOCIAL MEDIA ON THE PROCESS OF IDENTITY EXPLORATION AND THE EMERGENCE OF EATING DISORDERS IN STUDENT LIFE

As the physical and psychological well-being has become a cultural and public health focus in Western countries, the impact of social networking sites has been highlighted, especially for the young who are in the process of identity formation. For them, the rapidly evolving social media world is increasing in importance as the main arena for socializing, experimentation, exploration and communication. Studies connect the exposure of adolescents and young adults to social media with body image dissatisfaction and eating disorders (ED), mainly bulimia, anorexia and binge eating. Especially the media cultivating beauty ideals are predictors of the development of eating pathology. The aim of this study is to investigate the relationship between social media platforms and eating disorders in students and whether their use influences the process of identity formation. With a sample of 158 students from the University of Patras, the measuring instruments used in the study were a structured questionnaire to investigate the effect of social media on eating disorders and the process of identity exploration and the Bulimic Investigatory Test, Edinburgh (BITE) questionnaire to investigate the episodes of binge eating, predisposition to bulimia nervosa and the cognitive and behavioral manifestations of bulimia.  Article visualizations

Prevalence and associated factors of anxiety and depression in students at a Greek university during COVID-19 lockdown

Background: Restrictions on movement and lockdown are measures taken in many nations, in response to the COVID-19 pandemic. University students are additionally burdened by the transition to distance e-learning. The aims of the study were to investigate the prevalence of anxiety and depression in university students and to identify associated risk factors.Design and Methods: An online questionnaire was administered to 2,009 students in the University of Patras, Greece, during the national lockdown. Socio-demographic, academic data, and the forced disruption of daily life were assessed along with the Greek version of the Hospital Anxiety and Depression Scale.Results: Anxiety and depression prevalence was 35.8% and 51.2% respectively. Age, school of study, financial status, self-perceived health status, level of satisfaction with the state's and university's response and specific aspects in the daily routine were associated with both anxiety and depression scores. At higher odds of both depression and anxiety were students with low income, bad health status, annoyed at staying home and those who encountered difficulties with the online education system. Additional risk factors for depression were studies in humanities and social sciences, and low satisfaction with the university's response, while for anxiety were studies in agricultural sciences and absence of information about COVID-19.Conclusions: The proportion of Greek students showing depression and anxiety, during the restrictive measures, is alarming. Mental health in university students should be monitored. Mitigation strategies should focus on specific personal, academic and social variables that have been identified as protective factors

Evaluating New Approaches of Intervention in Reading Difficulties in Students with Dyslexia: The ilearnRW Software Application

The aim of this paper is to increase knowledge and understanding on how the implementation of language content through specialized software, such as the “Integrated Intelligent Learning Environment for Reading and Writing-iLearnRW”, can enhance learning during intervention procedures to enhance reading skills for children with dyslexia.The iLearnRW software is a newly designed tool that makes use of innovative technology and provides individualized intervention through games that incorporate learning activities, addressing those language areas that are most challenging for children with dyslexia in a highly entertaining and motivating way. Individualized intervention is provided through an underlying user profile, which incorporates these language features and is constantly updated as the child uses the software playing games, presenting language material selected based on his difficulties and recording his progress. A group of 78 students (52 male, 26 female) diagnosed with dyslexia, aged between 9 and 11 years old, was assessed for phonological, morphological and vocabulary skills. The students logged in the iLearnRW software on a mean of 14.18 days over a six-month intervention. After the 6-month intervention, the students were assessed once again on the same skills so as to establish the tool’s effectiveness.The results’ analysis revealed the following: (i) there was a strong constructional linkage between the profile entries of the sample, the language content of the tasks of the screening test as well of the games and its effectiveness in the students’ performance; (ii) the students who received specific guidance by their teachers, obtained higher success rates in most of the games than the students without any guidance, and (iii) the quantity of the language content and the time playing were not correlated with the students’ performance in the software’s games. Keywords: Digital technology, assistive computer software, dyslexia, learning environmen

Comparative analysis of xenobiotic metabolising N-acetyltransferases from ten non-human primates as in vitro models of human homologues

Xenobiotic metabolising N-acetyltransferases (NATs) perform biotransformation of drugs and carcinogens. Human NAT1 is associated with endogenous metabolic pathways of cells and is a candidate drug target for cancer. Human NAT2 is a well-characterised polymorphic xenobiotic metabolising enzyme, modulating susceptibility to drug-induced toxicity. Human NATs are difficult to express to high purification yields, complicating large-scale production for high-throughput screens or use in sophisticated enzymology assays and crystallography. We undertake comparative functional investigation of the NAT homologues of ten non-human primates, to characterise their properties and evaluate their suitability as models of human NATs. Considering the amount of generated recombinant protein, the enzymatic activity and thermal stability, the NAT homologues of non-human primates are demonstrated to be a much more effective resource for in vitro studies compared with human NATs. Certain NAT homologues are proposed as better models, such as the NAT1 of macaques Macaca mulatta and M. sylvanus, the NAT2 of Erythrocebus patas, and both NAT proteins of the gibbon Nomascus gabriellae which show highest homology to human NATs. This comparative investigation will facilitate in vitro screens towards discovery and optimisation of candidate pharmaceutical compounds for human NAT isoenzymes, while enabling better understanding of NAT function and evolution in primates

Entwicklung nachhaltiger Pflanzenschutzstrategien zur Bek_mpfung von Schadschmetterlingen im olivenanbau

Current olive growing practices range from the traditional Mediterranean olive grove to intensively managed olive plantations. Insecticides against major olive pests, like the olive moth (Prays oleae, Lep.: Yponomeutidae) and the jasmine moth, (Palpita unionalis, Lep.: Pyralidae) are still applied frequently. The European Union-funded international research project TRIPHELIO is aimed at the development of economically feasible and sustainable insecticide-free control methods for key Lepidopterous pests of olive. Main research activities focus on (1) the use of pheromones for mating disruption and improved monitoring of target pests, (2) habitat management strategies to enhance the activity of natural enemies in the olive grove, and (3) the use of inundative releases of mass-reared egg parasitoids of the genus Trichogramma. Moreover, tools for successful integration of the methods developed into an integrated pest management (IPM) strategy for olive pests were explored by optimising techniques for surveillance as well as considering potential side-effects of common pesticides on beneficial organisms. An intense exchange of scientific information and technology between European and North African countries was undertaken to create solutions for a wide range of olive growing regions. Key results and recommendations for further essential steps towards practical implementation are presented in this publication.Zusammenfassung Traditionelle, extensiv bearbeitete Olivenhaine, aber auch moderne Intensiv-Plantagen mit k_nstlicher Bew_sserung und hohem Einsatz von D_ngern bzw. chemischen Pflanzenschutzmitteln kennzeichnen die derzeitigen verschiedenen Anbauformen der Olive im Mittelmeerraum. Schadlepidopteren wie die Olivenmotte (Prays oleae, Lep.: Yponomeutidae) und die Jasminmotte (Palpita unionalis, Lep.: Pyralidae) werden durch regelm_ssigen Insektizideinsatz bek_mpft. Das von der EU gef_rderte internationale Forschungsprojekt TRIPHELIO zielte auf die Entwicklung insektizidfreier Alternativmethoden durch (1) die Optimierung der pheromongest _tzten _berwachung und Verwirrtechnik, (2) der Anwendung von Habitatmanagement-Strategien zur F_rderung nat_rlicher Gegenspieler, und (3) dem Einsatz von Trichogramma-Schlupfwespen. Zus_tzlich wurden Module f_r eine optimale Anwendung biotechnischer und biologischer Methoden bez_glich der Ph_nologie der Schadinsekten und m_glicher Nebenwirkungen von Pestiziden erarbeitet. Die intensive Kooperation zwischen Wissenschaftlern und Praktikern aus mehreren L_ndern Europas und Nordafrikas erlaubte den Entwurf m_glicher L_sungsans_tze f_r verschiedene Anbaubedingungen und klimatische Regionen des Mittelmeerraumes. Die wichtigsten Ergebnisse und Ausblicke f_r eine zuk_nftige praktische Umsetzung werden in dieser Ver_ffentlichung beschrieben

Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers

Background: Genome-wide association studies (GWAS) have identified 94 common single-nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 associated with ovarian cancer (OC) risk. Several of these are also associated with risk of BC or OC for women who carry a pathogenic mutation in the high-risk BC and OC genes BRCA1 or BRCA2. The combined effects of these variants on BC or OC risk for BRCA1 and BRCA2 mutation carriers have not yet been assessed while their clinical management could benefit from improved personalized risk estimates. Methods: We constructed polygenic risk scores (PRS) using BC and OC susceptibility SNPs identified through population-based GWAS: for BC (overall, estrogen receptor [ER]-positive, and ER-negative) and for OC. Using data from 15 252 female BRCA1 and 8211 BRCA2 carriers, the association of each PRS with BC or OC risk was evaluated using a weighted cohort approach, with time to diagnosis as the outcome and estimation of the hazard ratios (HRs) per standard deviation increase in the PRS. Results: The PRS for ER-negative BC displayed the strongest association with BC risk in BRCA1 carriers (HR = 1.27, 95% confidence interval [CI] = 1.23 to 1.31, P = 8.2 x 10(53)). In BRCA2 carriers, the strongest association with BC risk was seen for the overall BC PRS (HR = 1.22, 95% CI = 1.17 to 1.28, P = 7.2 x 10(-20)). The OC PRS was strongly associated with OC risk for both BRCA1 and BRCA2 carriers. These translate to differences in absolute risks (more than 10% in each case) between the top and bottom deciles of the PRS distribution; for example, the OC risk was 6% by age 80 years for BRCA2 carriers at the 10th percentile of the OC PRS compared with 19% risk for those at the 90th percentile of PRS. Conclusions: BC and OC PRS are predictive of cancer risk in BRCA1 and BRCA2 carriers. Incorporation of the PRS into risk prediction models has promise to better inform decisions on cancer risk management

The spectrum of BRCA1 and BRCA2 pathogenic sequence variants in Middle Eastern, North African, and South European countries.

BRCA1 BRCA2 mutational spectrum in the Middle East, North Africa, and Southern Europe is not well characterized. The unique history and cultural practices characterizing these regions, often involving consanguinity and inbreeding, plausibly led to the accumulation of population-specific founder pathogenic sequence variants (PSVs). To determine recurring BRCA PSVs in these locales, a search in PUBMED, EMBASE, BIC, and CIMBA was carried out combined with outreach to researchers from the relevant countries for unpublished data. We identified 232 PSVs in BRCA1 and 239 in BRCA2 in 25 of 33 countries surveyed. Common PSVs that were detected in four or more countries were c.5266dup (p.Gln1756Profs), c.181T>G (p.Cys61Gly), c.68_69del (p.Glu23Valfs), c.5030_5033del (p.Thr1677Ilefs), c.4327C>T (p.Arg1443Ter), c.5251C>T (p.Arg1751Ter), c.1016dup (p.Val340Glyfs), c.3700_3704del (p.Val1234Glnfs), c.4065_4068del (p.Asn1355Lysfs), c.1504_1508del (p.Leu502Alafs), c.843_846del (p.Ser282Tyrfs), c.798_799del (p.Ser267Lysfs), and c.3607C>T (p.Arg1203Ter) in BRCA1 and c.2808_2811del (p.Ala938Profs), c.5722_5723del (p.Leu1908Argfs), c.9097dup (p.Thr3033Asnfs), c.1310_1313del (p. p.Lys437Ilefs), and c.5946del (p.Ser1982Argfs) for BRCA2. Notably, some mutations (e.g., p.Asn257Lysfs (c.771_775del)) were observed in unrelated populations. Thus, seemingly genotyping recurring BRCA PSVs in specific populations may provide first pass BRCA genotyping platform.[CIMBA: The CIMBA data management and data analysis were supported by Cancer Research – UK grants C12292/A20861, C12292/A11174. iCOGS: the European Community's Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 - the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer (CRN-87521), and the Ministry of Economic Development, Innovation and Export Trade (PSR-SIIRI-701), Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The work of Barbara Pasini has been supported by the program "Dipartimenti di Eccellenza 2018 – 2022". Project n°D15D18000410001. This work was partially funded by the Associazione Italiana Ricerca Cancro (AIRC)"; IG2015 no.16732) to P. Peterlongo. Funds from Italian citizens who allocated the 5x1000 share of their tax payment in support of the Fondazione IRCCS Istituto Nazionale Tumori, according to Italian laws (INT-Institutional strategic projects ‘5x1000’) to S. Manoukian. DEMOKRITOS: European Union (European Social Fund – ESF) and Greek national funds through the Operational Program "Education and Lifelong Learning" of the National Strategic Reference Framework (NSRF) - Research Funding Program of the General Secretariat for Research & Technology: SYN11_10_19 NBCA. kConFab: The National Breast Cancer Foundation, and previously by the National Health and Medical Research Council (NHMRC), the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia. MAYO: NIH grants CA116167, CA192393 and CA176785, an NCI Specialized Program of Research Excellence (SPORE) in Breast Cancer (CA116201) and a grant from the Breast Cancer Research Foundation. UCHICAGO: NCI Specialized Program of Research Excellence (SPORE) in Breast Cancer (CA125183), R01 CA142996, 1U01CA161032 and by the Ralph and Marion Falk Medical Research Trust, the Entertainment Industry Fund National Women's Cancer Research Alliance and the Breast Cancer research Foundation. OIO is an ACS Clinical Research Professor. UCLA: Jonsson Comprehensive Cancer Center Foundation; Breast Cancer Research Foundation

BRCA2 polymorphic stop codon K3326X and the risk of breast, prostate, and ovarian cancers

Background: The K3326X variant in BRCA2 (BRCA2*c.9976A>T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations might account for this association. There is scant information about the effect of K3326X in other hormone-related cancers. Methods: Using weighted logistic regression, we analyzed data from the large iCOGS study including 76 637 cancer case patients and 83 796 control patients to estimate odds ratios (ORw) and 95% confidence intervals (CIs) for K3326X variant carriers in relation to breast, ovarian, and prostate cancer risks, with weights defined as probability of not having a pathogenic BRCA2 variant. Using Cox proportional hazards modeling, we also examined the associations of K3326X with breast and ovarian cancer risks among 7183 BRCA1 variant carriers. All statistical tests were two-sided. Results: The K3326X variant was associated with breast (ORw = 1.28, 95% CI = 1.17 to 1.40, P = 5.9x10- 6) and invasive ovarian cancer (ORw = 1.26, 95% CI = 1.10 to 1.43, P = 3.8x10-3). These associations were stronger for serous ovarian cancer and for estrogen receptor–negative breast cancer (ORw = 1.46, 95% CI = 1.2 to 1.70, P = 3.4x10-5 and ORw = 1.50, 95% CI = 1.28 to 1.76, P = 4.1x10-5, respectively). For BRCA1 mutation carriers, there was a statistically significant inverse association of the K3326X variant with risk of ovarian cancer (HR = 0.43, 95% CI = 0.22 to 0.84, P = .013) but no association with breast cancer. No association with prostate cancer was observed. Conclusions: Our study provides evidence that the K3326X variant is associated with risk of developing breast and ovarian cancers independent of other pathogenic variants in BRCA2. Further studies are needed to determine the biological mechanism of action responsible for these associations

Transitions to food democracy through multilevel governance

status: publishe