A map of the simulated tumor behavior regarding the dominant phenotypes as a function of the proliferation and diffusion rate of the invasive phenotype relative to phenotype 1 for A, B) the hypoxia-induced invasion (phenotype 2*) and C, D) the unconditional more invasive phenotype (phenotype 3*), under poor and well vascularized conditions, respectively.

<p>Points with blue color correspond to parametric pairs where the proliferative phenotype 1 dominates. With red color is represented the dominance of the invasive phenotype and with green color is depicted the region where a transition from the dominance of the proliferative phenotype 1 to the dominance of the invasive phenotype is observed.</p

Model parameters in dimensional and non-dimensional forms.

<p>Model parameters in dimensional and non-dimensional forms.</p

Values of characteristic properties for each tumor cell phenotype.

<p>Values of characteristic properties for each tumor cell phenotype.</p

An <i>in-slico</i> tumor consisting of a proliferative (phenotype 1) and a hypoxia-induced invasive (phenotype 2) sub-population as grows under poorly-vascularized (on the left column) and well-vascularized conditions (on the right column).

<p>A, D) The evolution of the corresponding normoxic sub-populations of each phenotype illustrates the dominance of phenotype 2. B, E) A central cross section of the tumor at day 50 and day 200 showing the spatial distribution of the viable sub-populations of the two phenotypes, respectively. C, F) The spatial distribution of viable (normoxic and hypoxic) cells after 200 fictitious days varying from blue color at the lowest cell density to red color at the highest observed as depicted in the corresponding colorbar.</p