Operational Control of the Feed of the Harvester

Comparison of normative and actual indicators on mining testifies to inefficient work of the excavating equipment. The results of the correlation analysis of the speed of movement of the harvester relative to the section of the support with the readings of methane sensors revealed a significant dependence. When conducting mining operations in complex geological conditions at great depths, a joint step-by-step carrying out of various technological processes is required to ensure the preparation, opening and excavation of reserves and the creation of safe conditions for mining coal seams. At the same time, efforts should be made to minimize time, human and energy resources. In this regard, of particular importance is the right choice of the program of operational management of technological processes of mining, monitoring the implementation of technological operations for the timely detection of deviations from the selected mode, adjustment of the established current modes of operation of technological processes and the development, if necessary, measures aimed at reducing the risks of accidents. A promising direction of solving this problem is the use of modeling methods. The developed models of technological processes of the mining enterprise will allow planning production and supporting decision-making in the implementation of operational management

Modelling Of Coal Transportation Technological Processes at Excavation

For efficient operation of a mining enterprise, the decisive role belongs to excavation areas forming volume of production and providing stability of support services. Taken engineering solutions to ensure permissible concentration of methane within working area depends on the nature of methane release (wall face, enclosing rocks, gob area, brokendown coal). Gas drainage operations from a working seam do not always provide reduction in methane emission to the required values and in these cases, effective and stable operation of an enterprise could be provided by the work of a shearer with an intensity that takes into account methane content in the developed seam, method of the working area preparation, ventilation scheme and vehicles characteristics. That is why modeling of broken-down coal transportation from the face, in order to determine the emitted methane, is an is an urgent task. The paper reviews issues of a mathematical model creation for coal transportation technological processes from the excavation area at the mine ‘Polysaevskaya’, JSC ‘SUEKKuzbass’

The Issues of Cryojet Technology Application for Rock Cutting

Water-jet technologies, based on the use of high-speed jets as cutting tools, are one of the promising directions of the destruction technologies for various materials. Jets’ capability to cut even very strong, anisotropic and composite materials, as well as their high cutting speed, that can be reached without workpiece reaction occurring on the tool, make them attractive from the point of view of their implementation as cutting tools. This paper outlines the methods of materials destruction by means of high-speed cryojet and discusses future areas of its application. The research reveals the main factors and criteria for evaluating the effectiveness of cryojet cutting. Experimental studies of the main factors affecting the cryojet cutting parameters were carried out using a bench unit. As a result of the experimental data analysis, we found the correspondences that can be used for calculating the cryojet cutting of various materials

On Modelling the Reliability of Concrete Support for Underground Construction Considering the Impact of Chemical Erosion

Ensuring the reliability of support in mine workings has always been one of the most important scientific and technical problems in mining. To ensure the normal operation of underground structures, it is necessary to apply special measures to maintain the support, providing increased stability of rock array. To one of the most important measures is to maintain the reliability of the supports in underground workings and objects of underground construction. The main method of research in this area is the modeling of the reliability of concrete support, as applied to various exogenous and endogenous factors of disturbance. The article provides theoretical provisions of research in physico-chemical processes of corrosion in reinforced concrete for modelling the reliability of structural elements of supports for underground construction objects

Methodical Approach to the Rent Considering in the Mineral Resources Evaluation

Movement to the multisectoral economy strengthens the tendencies of development and improvement of rental relations and ways of accounting rent as the assessed value of natural resources. At the same time, objective ecological and economical assessment should provide an adequate share of profit to every participant of development and processing of minerals: to the state and to the region – the administrative unit of RF, as the proprietor of the subsoil and minerals (obviously, this is the absolute rent and differential rent I), to the shareholder or the leaseholder, to the production worker (differential rent II), to the financier (the state, the bank or other legal entity), which have pretensions of the interest

Interstitial electrical stimulation for middle-aged, and elderly adults with early stages of knee osteoarthritis

of early stages of deforming osteoarthritis of the knee joint. There is a need to explore the effectiveness and mechanisms of modern methods of electrical therapy and their impact on the quality of life due to close cause-and-effect relationship between the pain, inflammatory and destructive components of osteoarthritis (OA) as one of the most common conditions. The objective was to evaluate the effect of interstitial electrical stimulation (IES) as a monotherapy in the course of conservative treatment of early stages of gonarthrosis based on clinical and biochemical findings. Materials and methods Radiographic findings, skin electrometry (objective parameters of pain intensity), limb weight-bearing capacity, biochemical parameters of connective tissue matrix degradation in blood serum and 24-hour urine samples, and treatment satisfaction were explored in 43 patients. Patients who received a course of IES were assigned to the treatment group (n = 22) and patients who received standard treatment without IES constituted the control group (n = 21). Results Electrometric analysis showed a higher effectiveness of pain relief in the treatment group compared to the controls with asymmetry coefficient measuring 3.2 ± 0.31 versus 1.9 ± 0.4 at p > 0.05. The weight‑bearing scored 3.59 ± 0.34 versus 3.26 ± 0.2 at p > 0.05. The treatment group showed shorter treatment length with 13.21 ± 1.2 days versus 18.3 ± 1.2 days in the control group at p > 0.05 and a higher degree of satisfaction with outcomes scored 96.2 ± 2.59 in the treatment group versus 86.2 ± 3.17 in the control group. A statistically significant difference (p > 0.05) was established in the levels of free and total hydroxyproline characterizing the different intensity of collagen breakdown in the groups at the end of treatment. Discussion The IES used as an analgesic and anti-inflammatory therapy was shown to be highly effective with changes in the hydroxyproline level in the media suggesting a chondroprotective effect. The analysis and comparison of objective parameters demonstrated high effectiveness of IES in the treatment of early stages of gonarthrosis in middle-aged and elderly adults. Conclusion The IES used for treatment of early stages of gonarthrosis helps pain reducing the intensity of collagen destruction and improving weight-bearing

Sports Nutrition: Diets, Selection Factors, Recommendations

An athlete’s diet is influenced by external and internal factors that can reduce or exacerbate exercise-induced food intolerance/allergy symptoms. This review highlights many factors that influence food choices. However, it is important to remember that these food choices are dynamic, and their effectiveness varies with the time, location, and environmental factors in which the athlete chooses the food. Therefore, before training and competition, athletes should follow the recommendations of physicians and nutritionists. It is important to study and understand the nutritional strategies and trends that athletes use before and during training or competitions. This will identify future clinical trials that can be conducted to identify specific foods that athletes can consume to minimize negative symptoms associated with their consumption and optimize training outcomes

TRIM28 Is a Novel Regulator of CD133 Expression Associated with Cancer Stem Cell Phenotype

CD133 is an extensively studied marker of the most malignant tumor cell population, designated as cancer stem cells (CSCs). However, the function of this glycoprotein and its involvement in cell regulatory cascades are still poorly understood. Here we show a positive correlation between the level of CD133 plasma membrane expression and the proliferative activity of cells of the Caco-2, HT-29, and HUH7 cancer cell lines. Despite a substantial difference in the proliferative activities of cell populations with different levels of CD133 expression, transcriptomic and proteomic profiling revealed only minor distinctions between them. Nonetheless, a further in silico assessment of the differentially expressed transcripts and proteins revealed 16 proteins that could be involved in the regulation of CD133 expression; these were assigned ranks reflecting the apparent extent of their involvement. Among them, the TRIM28 transcription factor had the highest rank. The prominent role of TRIM28 in CD133 expression modulation was confirmed experimentally in the Caco2 cell line clones: the knockout, though not the knockdown, of the TRIM28 gene downregulated CD133. These results for the first time highlight an important role of the TRIM28 transcription factor in the regulation of CD133-associated cancer cell heterogeneity

Genetic screening of an endemic mutation in the DYSF gene in an isolated, mountainous population in the Republic of Dagestan

Abstract Background Dysferlinopathy has a high prevalence in relatively isolated ethnic groups where consanguineous marriages are characteristic and/or the founder effect exists. However, the frequency of endemic mutations in most isolates has not been investigated. Methods The prevalence of the pathological DYSF gene variant (NM_003494.4); c.200_201delinsAT, p. Val67Asp (rs121908957) was investigated in an isolated Avar population in the Republic of Dagestan. Genetic screenings were conducted in a remote mountainous region characterized by a high level of consanguinity among its inhabitants. In total, 746 individuals were included in the screenings. Results This pathological DYSF gene variant causes two primary phenotypes of dysferlinopathy: limb‐girdle muscular dystrophy (LGMD) type R2 and Miyoshi muscular dystrophy type 1. Results indicated a high prevalence of the allele at 14% (95% confidence interval [CI]: 12–17; 138 out of 1518 alleles), while the allele in the homozygous state was detected in 29 cases—3.8% (CI: 2.6–5.4). The population load for dysferlinopathy was 832.3 ± 153.9 per 100,000 with an average prevalence of limb‐girdle muscular dystrophies ranging from 0.38 ± 0.38 to 5.93 ± 1.44 per 100,000. Conclusion A significant burden of the allele was due to inbreeding, as evidenced by a deficiency of heterozygotes and the Wright fixation index equal to 0.14 (CI 0.06–0.23)