Formation and Dissociation of Phosphorylated Peptide Radical Cations

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Emphysematous pyelonephritis: an eight-year retrospective review across four hospitals in a single cluster

香港泌尿外科學會Moderated Poster (Free Paper) Session II - Upper Tract and Robotic Surgery: MP.2-1OBJECTIVE: Emphysematous pyelonephritis (EPN) is a rare but life-threatening infection. We aim to review our cluster’s experience of managing this urologic emergency. PATIENTS & METHODS: Case notes of patients with EPN in four acute hospitals in the KWC (PMH, CMC, KWH and YCH) were retrospectively reviewed. The patients’ demographic data, clinical presentation, investigation findings, treatment and outcome were studied. OBJECTIVE: Emphysematous pyelonephritis (EPN) is a rare but life-threatening infection. We aim to review our cluster’s experience of managing this urologic emergency. PATIENTS & METHODS: Case notes of patients with EPN in four acute hospitals in the KWC (PMH, CMC, KWH and YCH) were retrospectively reviewed. The patients’ demographic data, clinical presentation, investigation findings, treatment and outcome were studied.published_or_final_versionThe 17th Annual Scientific Meeting of the Hong Kong Urological Association, Hong Kong, 6 November 2011. In Program Book, 2011, p. 6

HIGH-ENERGY EMISSIONS FROM THE GAMMA-RAY BINARY LS 5039

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Fermi-lat Detection Of Pulsed Gamma-rays Above 50 Gev From The Vela Pulsar

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MULTI-WAVELENGTH EMISSIONS FROM THE MILLISECOND PULSAR BINARY PSR J1023+0038 DURING AN ACCRETION ACTIVE STATE

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Targeting the TGF-β1 Pathway to Prevent Normal Tissue Injury After Cancer Therapy

Evidence supporting the critical role of transforming growth factor β1 in the development of normal tissue injury after cancer therapy is reviewed and the results of recent research aimed at preventing normal tissue injury by targeting the transforming growth factor β1 pathway are presented

Hypoxia causes transgenerational impairments in reproduction of fish

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Harnessing the Potential of CRISPR/Cas in Atherosclerosis: Disease Modeling and Therapeutic Applications

Atherosclerosis represents one of the major causes of death globally. The high mortality rates and limitations of current therapeutic modalities have urged researchers to explore potential alternative therapies. The clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR/Cas9) system is commonly deployed for investigating the genetic aspects of Atherosclerosis. Besides, advances in CRISPR/Cas system has led to extensive options for researchers to study the pathogenesis of this disease. The recent discovery of Cas9 variants, such as dCas9, Cas9n, and xCas9 have been established for various applications, including single base editing, regulation of gene expression, live-cell imaging, epigenetic modification, and genome landscaping. Meanwhile, other Cas proteins, such as Cas12 and Cas13, are gaining popularity for their applications in nucleic acid detection and single-base DNA/RNA modifications. To date, many studies have utilized the CRISPR/Cas9 system to generate disease models of atherosclerosis and identify potential molecular targets that are associated with atherosclerosis. These studies provided proof-of-concept evidence which have established the feasibility of implementing the CRISPR/Cas system in correcting disease-causing alleles. The CRISPR/Cas system holds great potential to be developed as a targeted treatment for patients who are suffering from atherosclerosis. This review highlights the advances in CRISPR/Cas systems and their applications in establishing pathogenetic and therapeutic role of specific genes in atherosclerosis.</jats:p

Identification and characterization of seed-specific transcription factors regulating anthocyanin biosynthesis in black rice

Black rice is rich in anthocyanin and is expected to have more healthful dietary potential than white rice. We assessed expression of anthocyanin in black rice cultivars using a newly designed 135 K Oryza sativa microarray. A total of 12,673 genes exhibited greater than 2.0-fold up- or down-regulation in comparisons between three rice cultivars and three seed developmental stages. The 137 transcription factor genes found to be associated with production of anthocyanin pigment were classified into 10 groups. In addition, 17 unknown and hypothetical genes were identified from comparisons between the rice cultivars. Finally, 15 out of the 17 candidate genes were verified by RT-PCR analysis. Among the genes, nine were up-regulated and six exhibited down-regulation. These genes likely play either a regulatory role in anthocyanin biosynthesis or are related to anthocyanin metabolism during flavonoid biosynthesis. While these genes require further validation, the results here underline the potential use of the new microarray and provide valuable insight into anthocyanin pigment production in rice