Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and sysemic lupus erythematosus

Nitric oxide (NO) has been shown to regulate T cell functions under physiological conditions, but overproduction of NO may contribute to T lymphocyte dysfunction. NO-dependent tissue injury has been implicated in a variety of rheumatic diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Several studies reported increased endogenous NO synthesis in both SLE and RA, and recent evidence suggests that NO contributes to T cell dysfunction in both autoimmune diseases. The depletion of intracellular glutathione may be a key factor predisposing patients with SLE to mitochondrial dysfunction, characterized by mitochondrial hyperpolarization, ATP depletion and predisposition to death by necrosis. Thus, changes in glutathione metabolism may influence the effect of increased NO production in the pathogenesis of autoimmunity

Grazing for carbon

International audienceThe potential of grasslands as a carbon (C) sink in Europe is large despite the number of uncertainties related to the effect of grazing systems on C sequestration. The EIP-AGRI Focus Group (FG) ‘Grazing for Carbon’, a temporary group of 20 selected European experts from research and practice, shared knowledge and experience from different disciplines on the relationship between grazing and soil C. The FG explored grazing management strategies, drivers and barriers for different grazing systems, as well as tools and business models to support them successfully. The overall aim was to identify how to increase the soil C content in grazing systems. Six priorities were addressed: the effects and trade-offs associated with approaches to sequestering C in different grazing systems, the effect of grazing on C and soil nutrients, the role of plant mixtures and native species, general guidelines for optimal grazing, effective monitoring of soil C as a tool for soil quality evaluation and incentives to promote the adoption of grazing systems to optimise soil C content