Schizophrenia and oral health: a literature review [Skizofrénia és szájhigiénia: irodalmi áttekintés]

Az általános betegségek közvetlenül vagy közvetve befolyásolhatják a fogak egészségét és a páciens szájhigiénéjét.A fogorvosi rendelőben megjelenő betegek körében a pszichiátriai kórképek a leggyakoribb rendellenességek közé tartoznak.A fogászati kezelések során az érintetteknek speciális igényeik vannak. A skizofrénia egy olyan krónikus mentálisbetegség, amely a személyes érzelmek és érzések zavaraival jár, illetve mentális és bizonyos tudati funkciók romlásáhozvezet. A tünetek közé tartoznak a téveszmék, a hallucinációk, a rendezetlen gondolkodás és a következetlenség.Amennyiben hasadásos elmezavarban szenvedő páciens jelentkezik kezelésre a fogorvosi rendelőben, pszichiátriaikonzultációt kell biztosítani. Az elektív fogászati beavatkozásokat el kell halasztani mindaddig, amíg a páciens tüneteikontroll alá kerülnek. A gyógyszerek mellékhatásai súlyosak lehetnek, ezért elengedhetetlen a beteg gondos és folyamatosellenőrzése

Toward Personalized Oral Diagnosis: Distinct Microbiome Clusters in Periodontitis Biofilms

Periodontitis is caused by pathogenic subgingival microbial biofilm development and dysbiotic interactions between host and hosted microbes. A thorough characterization of the subgingival biofilms by deep amplicon sequencing of 121 individual periodontitis pockets of nine patients and whole metagenomic analysis of the saliva microbial community of the same subjects were carried out. Two biofilm sampling methods yielded similar microbial compositions. Taxonomic mapping of all biofilms revealed three distinct microbial clusters. Two clinical diagnostic parameters, probing pocket depth (PPD) and clinical attachment level (CAL), correlated with the cluster mapping. The dysbiotic microbiomes were less diverse than the apparently healthy ones of the same subjects. The most abundant periodontal pathogens were also present in the saliva, although in different representations. The single abundant species Tannerella forsythia was found in the diseased pockets in about 16–17-fold in excess relative to the clinically healthy sulcus, making it suitable as an indicator of periodontitis biofilms. The discrete microbial communities indicate strong selection by the host immune system and allow the design of targeted antibiotic treatment selective against the main periodontal pathogen(s) in the individual patients

Toward Personalized Oral Diagnosis: Distinct Microbiome Clusters in Periodontitis Biofilms

Periodontitis is caused by pathogenic subgingival microbial biofilm development and dysbiotic interactions between host and hosted microbes. A thorough characterization of the subgingival biofilms by deep amplicon sequencing of 121 individual periodontitis pockets of nine patients and whole metagenomic analysis of the saliva microbial community of the same subjects were carried out. Two biofilm sampling methods yielded similar microbial compositions. Taxonomic mapping of all biofilms revealed three distinct microbial clusters. Two clinical diagnostic parameters, probing pocket depth (PPD) and clinical attachment level (CAL), correlated with the cluster mapping. The dysbiotic microbiomes were less diverse than the apparently healthy ones of the same subjects. The most abundant periodontal pathogens were also present in the saliva, although in different representations. The single abundant species Tannerella forsythia was found in the diseased pockets in about 16–17-fold in excess relative to the clinically healthy sulcus, making it suitable as an indicator of periodontitis biofilms. The discrete microbial communities indicate strong selection by the host immune system and allow the design of targeted antibiotic treatment selective against the main periodontal pathogen(s) in the individual patients