Demonstration of the broadband half-wave plate using the nine-layer sapphire for the cosmic microwave background polarization experiment

International audienceWe report the development of the achromatic half-wave plate (AHWP) at millimeter wave for cosmic microwave background polarization experiments. We fabricate an AHWP consisting of nine A-cut sapphire plates based on the Pancharatnam recipe to cover a wide frequency range. The modulation efficiency and the phase are measured in a frequency range of 33 to 260 GHz with incident angles up to 10 deg. We find the measurements at room temperature are in good agreement with the predictions. This is the most broadband demonstration of an AHWP at millimeter wave.</p

Demonstration of the broadband half-wave plate using the nine-layer sapphire for the CMB polarization experiment

International audienceWe report the development of the achromatic half-wave plate (AHWP) at millimeter wave for cosmic microwave background polarization experiments. We fabricate an AHWP consisting of nine A-cut sapphire plates based on the Pancharatnam recipe to cover a wide frequency range. The modulation efficiency and the phase are measured in a frequency range of 33 to 260 GHz with incident angles up to 10 deg. We find the measurements at room temperature are in good agreement with the predictions. This is the most broadband demonstration of an AHWP at millimeter wave.</p

Prototype design and evaluation of the nine-layer achromatic half-wave plate for the LiteBIRD low frequency telescope

International audienceLiteBIRD is a satellite project to measure the polarization of the CMB with an unprecedented accuracy. LiteBIRD observes all sky for three years at the sun-earth second Lagrange point. The goal of LiteBIRD is to observe the B-mode polarization at large angular scales and to measure the tensor-to-scaler ratio r with an accuracy less than 0.001, exploring the energy scale of the inflation. In order to mitigate the system 1/f noise and systematics, we plan to use continuous rotating half-wave plates (HWPs) as a polarization modulator at each aperture of two telescopes. One of the telescopes, called a low frequency telescope (LFT), covers the frequency range from 34 to 270 GHz, requiring the HWP to have a high modulation efficiency in the wide bandwidth. We employ a Pancharatnam-type achromatic HWP (AHWP) to achieve the broadband coverage. The AHWP consists of nine layer stacked HWPs with the optic axes mutually rotated by the angles optimized for the LFT bandwidth. In this paper, we report our development status of the nine layer AHWP and measurement results on the modulation efficiency and the phase as a function of frequency

Prognostic Significance of C-Reactive Protein in Lenvatinib-Treated Unresectable Hepatocellular Carcinoma: A Multi-Institutional Study

Background: Serum C-reactive protein (CRP) is an established biomarker for acute inflammation and has been identified as a prognostic indicator for hepatocellular carcinoma (HCC). However, the significance of the serum CRP level, specifically in HCC patients treated with lenvatinib, remains unclear. Methods: We retrospectively analyzed 125 HCC patients who received lenvatinib treatment at six centers. Clinical characteristics were assessed to identify clinical associations between serum CRP and HCC prognosis. Results: The median overall serum CRP level was 0.29 mg/dL. The cohort was divided into two groups: the low-CRP group with a serum CRP p p = 0.411), while time-to-treatment failure (TTF) was significantly longer in the low-CRP group (8.5 vs. 4.4 months, p = 0.007). The discontinuation rate due to poor performance status was significantly higher in the high-CRP group (p < 0.001). Conclusion: A baseline serum CRP level exceeding 0.5 mg/dL was identified as an unfavorable prognostic factor in HCC patients receiving lenvatinib treatment