2 research outputs found
A nationwide follow-up study of occupational organic dust exposure and risk of chronic obstructive pulmonary disease (COPD)
Objectives To study exposure-response relations
between cumulative organic dust exposure and incident
chronic obstructive pulmonary disease (COPD) among
subjects employed in the Danish farming and wood
industry.
Methods We studied exposure-response relations
between cumulative organic dust exposure and incident
COPD (1997–2013) among individuals born during
1950–1977 in Denmark ever employed in the farming
or wood industry (n=1 75 409). Industry-specific
employment history (1964–2007), combined with
time-dependent farming and wood industry-specific
exposure matrices defined cumulative exposure. We used
logistic regression analysis with discrete survival function
adjusting for age, sex and calendar year. Adjustment for
smoking status was explored in a subgroup of 4023 with
smoking information available.
Results Cumulative organic dust exposure was inversely
associated with COPD (adjusted rate ratios (RRadj
(95% CIs) of 0.90 (0.82 to 0.99), 0.76 (0.69 to 0.84) and
0.52 (0.47 to 0.58) for intermediate-low, intermediatehigh and high exposure quartiles, respectively, compared
with the lowest exposure quartile). Lagging exposure 10
years was not consistently suggestive of an association
between cumulative exposure and COPD; RRadj (95% CI):
1.05 (0.94 to 1.16), 0