Mutations in the ELANE Gene are Associated with Development of Periodontitis in Patients with Severe Congenital Neutropenia

# The Author(s) 2011. This article is published with open access at Springerlink.com Background Patients with severe congenital neutropenia (SCN) often develop periodontitis despite standard medical and dental care. In light of previous findings that mutations in the neutrophil elastase gene, ELANE, are associated with more severe neutropenic phenotypes, we hypothesized an association between the genotype of SCN and development of periodontitis. Methods Fourteen Swedish patients with SCN or cyclic neutropenia harboring different genetic backgrounds were recruited for periodontal examination. Peripheral blood, gingival crevicular fluid (GCF), and subgingival bacterial Thomas Modéer and Katrin Pütsep have contributed equally to the study

Map of M'Kean County, Pennsylvania /

Shows townships (including Shippen Twp., now part of Cameron County), warranty-deed tracts with numbers/warrantees' initials, some real-property tracts with owners' names, and rural buildings with householders' names.Hand col. to distinguish townships.LC copy imperfect: Brittle, darkened by lamination, quartered (later conjoined), annotated in lead pencil, missing small sections at edges and cut lines. DLCIncludes ill. of rampant eagle at head of title.LC Land ownership maps, 77