Synthesis, Spectroscopy and Crystal Structure of 2‐Ethyl‐6‐(4‐nitrophenyl)imidazo[2,1‐b] [1,3,4]thiadiazole‐5‐carbaldehyde.

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Synthesis, spectroscopic and crystal structure analysis of a compound with pharmocophoric substituent: 2-cyclohexyl-6-(2-oxo-2H-chromen-3-yl)- imidazo[2,1-b] [1,3,4]thiadiazole-5-carbaldehyde

Imidazo[2,1-b][1,3,4] thiadiazole derivatives are significant for their various pharmacological properties. This paper reports the synthesis and structure of one of them, 2-cyclohexyl-6-(2-oxo-2H-chromen-3-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde. The compound crystallizes in the monoclinic space group P21/c with a=17.316(3)Å, b=6.5420(9)Å, c =17.056(3)Å, β=112.909(2)°, V=1779.7(4)Å3, z=4. The, Imidazo[2,1-b][1,3,4] thiadiazole and the coumarin ring systems are each planar but inclined at an angle of 48.14(2)° towards each other. The crystal structure is stabilized by C–H … O interactions

2-Ethyl-6-(4-methoxy-phen-yl)imidazo2,1-b1,3,4thia-diazole-5- carbaldehyde

In the title compound, C14H13N3O2S, the imidazothia­diazole ring system and the methoxy­phenyl ring are not coplanar, having an angle of 31.60 (7)° between their mean planes. In the crystal structure, inter­molecular C-H...O hydrogen-bond inter­actions link the mol­ecules into dimers and [pi]-[pi] stacking inter­actions reinforce the crystal cohesion

Synthesis, spectroscopic and crystal structure analysis of a compound with pharmocophoric substituent: 2-Cyclohexyl-6-(2-oxo-2H-chromen-3-yl)-imidazo2,1- b1,3,4thiadiazole-5-carbaldehyde

Imidazo[2,1-b][1,3,4] thiadiazole derivatives are significant for their various pharmacological properties. This paper reports the synthesis and structure of one of them, 2-cyclohexyl-6-(2-oxo-2H-chromen-3-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde. The compound crystallizes in the monoclinic space group P21/c with a=17.316(3)Å, b=6.5420(9)Å, c =17.056(3)Å, β=112.909(2)°, V=1779.7(4)Å3, z=4. The, Imidazo[2,1-b][1,3,4] thiadiazole and the coumarin ring systems are each planar but inclined at an angle of 48.14(2)° towards each other. The crystal structure is stabilized by C–H … O interactions

ChemInform Abstract: Synthesis, Spectroscopy and Crystal Structure of 2‐Cyclohexyl5‐formyl6(4bromophenyl)imidazo[2,1‐b] [1,3,4]thiadiazole.

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Synthesis, spectroscopic and crystal structure analysis of N-imidazolidin-2-ylidene-5-(thien-2-yl)1,3,4thiadiazole-2-amine

The crystal structure of the title compound has been determined. The compound crystallizes in the monoclinic space group P21/c with a = 5.9885(2) Å, b = 14.7345(4) Å, c = 12.3719(4) Å, β = 96.655(5)°, V = 1084.31(8) Å3, z = 4. An intramolecular N-H•••N hydrogen bond forms a pseudo-six-membered ring with graph set S 1 1(6). The crystal structure is stabilized by intermolecular interactions of the type N-H•••N and C-H•••N. The packing motifs in accordance with Etter's analysis are R 2 2(8) corresponding to N-H•••N dimer and that generated by the chain is C(7). © 2007 Springer Science BUSINESS Media, LLC

Synthesis, spectroscopy and crystal structure of 2-ethyl-6-(4-nitrophenyl) imidazo2,1-b1,3,4thiadiazole-5-carbaldehyde

The preparation of 2-ethyl-6-(4-nitrophenyl)imidazo2,1-b1,3,4 thiadiazole-5-carbaldehyde (4) is described and its crystal structure is determined and discussed