Impact of individual and household characteristics on the employment probability among youth from Bosnia and Herzegovina

Employment has been identified at the top of the list of young people’s concerns across Europe. Given the fact that in Bosnia and Herzegovina youth is one of the most vulnerable group, mainly due to the high unemployment rate, the main goal of this paper to determine the key individual and household characteristics of young people that influence their employment probability in order to support further development of decision-making policies in the labour market of Bosnia and Herzegovina. By using the USAID MEASURE-BiH National Youth Survey data set we analyse the effects of various individual and household characteristics on the probability of youth employment in Bosnia and Herzegovina. The analysis has revealed that education, age, gender and certain household characteristics have an impact on the probability of youth employment. The paper is expected to produce useful pieces of information that might be helpful for government decision- makers in Bosnia and Herzegovina in the process of creating employment policies to support young people

Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production

OBJECTIVE—The fuel sensor AMP-activated protein kinase (AMPK) in the hypothalamus regulates energy homeostasis by sensing nutritional and hormonal signals. However, the role of hypothalamic AMPK in glucose production regulation remains to be elucidated. We hypothesize that bidirectional changes in hypothalamic AMPK activity alter glucose production. RESEARCH DESIGN AND METHODS—To introduce bidirec-tional changes in hypothalamic AMPK activity in vivo, we first knocked down hypothalamic AMPK activity in male Sprague-Dawley rats by either injecting an adenovirus expressing the dominant-negative form of AMPK (Ad-DN AMPK2 [D157A]) or infusing AMPK inhibitor compound C directly into the medio-basal hypothalamus. Next, we independently activated hypotha-lamic AMPK by delivering either an adenovirus expressing the constitutive active form of AMPK (Ad-CA AMPK1312 [T172D]

Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis

The central nervous system (CNS) is capable of gathering information on the body’s nutritional state and it implements appropriate behavioral and metabolic responses to changes in fuel availability. This feedback signaling of peripheral tissues ensures the maintenance of energy homeostasis. The hypothalamus is a primary site of convergence and integration for these nutrient-related feedback signals, which include central and peripheral neuronal inputs as well as hormonal signals. Increasing evidence indicates that glucose and lipids are detected by specialized fuel-sensing neurons that are integrated in these hypothalamic neuronal circuits. The purpose of this review is to outline the current understanding of fuel-sensing mechanisms in the hypothalamus, to integrate the recent findings in this field, and to address the potential role of dysregulation in these pathways in the development of obesity and type 2 diabetes mellitus

Reti neurali e loro applicazioni

Nella seguente tesina vengono presentate le reti neurali feedforward. La tesina inizia con una serie di nozioni basilari, tra cui un quadro semplificato del funzionamento delle reti neurali biologiche. Sono presentati poi in dettaglio due modelli di reti chiamati, rispettivamente, multilayer perceptron e radial basis function. Viene affrontato il problema del loro addestramento e successivamente vengono presentate alcune tecniche volte ad ottimizzare il loro funzionamento. Infine vengono dati due esempi di applicazione pratica delle reti neural

Design of Programmable Phase Shifters and Attenuators in 130nm CMOS Technology

This thesis proposes the analysis and design of a phase shifter and a programmable attenuator for Doherty Power Amplifier (DPA) application, using the Infineon 130nm CMOS technology. The DPA is an architecture often used in nowadays cellular base-stations and the control of phase and amplitude in this system allows to optimize its efficienc

Mechanisms of Hypothalamic and Small Intestinal Nutrient Sensing

Nutrient sensing pathways in both the brain and gut decrease hepatic glucose production. Hypothalamic activation of lactate metabolism decreases glucose production, but it is unknown whether the hypothalamus detects circulating lactate to maintain glucose homeostasis. In the gut, lipids decrease glucose production via a neuronal network but the downstream signaling mechanisms are unknown. We tested whether circulating lactate activates central lactate metabolism to decrease glucose production and postulated that duodenal protein kinase C (PKC) acts downstream of lipids to decrease glucose production through a neuronal network. We report that central lactate metabolism is required for the maintenance of glucose homeostasis in the presence of circulating lactate and that activation of duodenal PKC is required for lipids to decrease glucose production. This shows the importance of the brain and gut in the regulation of glucose production, and could pave the way for restoration of glucose homeostasis in disease.MAS