Systematic Measurements of Heat Transfer Characteristics in Saturated Pool Boiling of Water-Based Nanofluids

Experiments were carried out to investigate the heat transfer characteristics in saturated pool boiling of water-based nanofluids. An upward-facing copper surface of 20 mm in diameter was used as the heated surface. Main experimental parameters in this work were nanoparticles’ material (TiO2, Al2O3 and SiO2), mass concentration (0.04, 0.4 and 1 kg/m3) and dispersion condition (fine and coarse dispersions). Effects of these parameters on the time-variation of wall superheat under constant heat flux, the heat transfer coefficient (boiling curve) and the critical heat flux (CHF) were explored. It was found that the particle dispersion condition has no noticeable influence on the heat transfer characteristics within the range tested in this work. Whilst, the material and concentration of nanoparticles greatly affected the time-variation of wall superheat and the boiling curve. In particular, it was found that the wall superheat likely to increase significantly when the nanoparticle layer formed on the heated surface is partially detached. The CHF in nanofluid was 2.5–3 times higher than that for pure water in all the experimental conditions

The c-MYC-ABCB5 axis plays a pivotal role in 5-fluorouracil resistance in human colon cancer cells

c-MYC overexpression is frequently observed in various cancers including colon cancer and regulates many biological activities such as aberrant cell proliferation, apoptosis, genomic instability, immortalization and drug resistance. However, the mechanism by which c-MYC confers drug resistance remains to be fully elucidated. In this study, we found that the c-MYC expression level in primary colorectal cancer tissues correlated with the recurrence rate following 5-fluorouracil (5-FU)-based adjuvant chemotherapy. Supporting this finding, overexpression of exogenous c-MYC increased the survival rate following 5-FU treatment in human colon cancer cells, and knockdown of endogenous c-MYC decreased it. Furthermore, c-MYC knockdown decreased the expression level of ABCB5, which is involved in 5-FU resistance. Using a chromatin immunoprecipitation assay, we found that c-MYC bound to the ABCB5 promoter region. c-MYC inhibitor (10058-F4) treatment inhibited c-MYC binding to the ABCB5 promoter, leading to a decrease in ABCB5 expression level. ABCB5 knockdown decreased the survival rate following 5-FU treatment as expected, and the ABCB5 expression level was increased in 5-FU-resistant human colon cancer cells. Finally, using a human colon cancer xenograft murine model, we found that the combined 5-FU and 10058-F4 treatment significantly decreased tumorigenicity in nude mice compared with 5-FU or 10058-F4 treatment alone. 10058-F4 treatment decreased the ABCB5 expression level in the presence or absence of 5-FU. In contrast, 5-FU treatment alone increased the ABCB5 expression level. Taken together, these results suggest that c-MYC confers resistance to 5-FU through regulating ABCB5 expression in human colon cancer cells

SIMULATION-BASED ASSESSMENT KINERJA TERMAL PADA CONCENTRIC TUBE HEAT EXCHANGER

The double-pipe heat exchanger is one of the most popular heat exchanger devices. In this study, the concentric tube heat exchanger as the double pipe heat exchanger device was simulated with ANSYS code FLUENT. The simulation was done by based on the Reynolds number variation from 400010.000 using the method of co-current and counter flow. The hydrodynamic and thermal simulation results agree with the empirical correlation of the Pethukov and Dittus-Bolter equations, respectively. The friction factors of the water base fluid and nanofluid f TiO2/water f (0.1 vol.%) do not result in a significant difference in the turbulent flow regime for both co-current and counter flow. The thermal performance of TiO2/water (0.1% vol) nanofluid as indicated by the value of the heat transfer coefficient results in an increase of 6.9% for counter low flow and 6.0% for co-current flow. Meanwhile, the direction of fluid flow in the heat exchanger does not have a significant effect on its thermal performance

The Japanese space gravitational wave antenna; DECIGO

DECi-hertz Interferometer Gravitational wave Observatory (DECIGO) is the future Japanese space gravitational wave antenna. DECIGO is expected to open a new window of observation for gravitational wave astronomy especially between 0.1 Hz and 10 Hz, revealing various mysteries of the universe such as dark energy, formation mechanism of supermassive black holes, and inflation of the universe. The pre-conceptual design of DECIGO consists of three drag-free spacecraft, whose relative displacements are measured by a differential Fabry– Perot Michelson interferometer. We plan to launch two missions, DECIGO pathfinder and pre- DECIGO first and finally DECIGO in 2024

DECIGO pathfinder

DECIGO pathfinder (DPF) is a milestone satellite mission for DECIGO (DECi-hertz Interferometer Gravitational wave Observatory) which is a future space gravitational wave antenna. DECIGO is expected to provide us fruitful insights into the universe, in particular about dark energy, a formation mechanism of supermassive black holes, and the inflation of the universe. Since DECIGO will be an extremely large mission which will formed by three drag-free spacecraft with 1000m separation, it is significant to gain the technical feasibility of DECIGO before its planned launch in 2024. Thus, we are planning to launch two milestone missions: DPF and pre-DECIGO. The conceptual design and current status of the first milestone mission, DPF, are reviewed in this article

Current status of space gravitational wave antenna DECIGO and B-DECIGO

Deci-hertz Interferometer Gravitational Wave Observatory (DECIGO) is the future Japanese space mission with a frequency band of 0.1 Hz to 10 Hz. DECIGO aims at the detection of primordial gravitational waves, which could be produced during the inflationary period right after the birth of the universe. There are many other scientific objectives of DECIGO, including the direct measurement of the acceleration of the expansion of the universe, and reliable and accurate predictions of the timing and locations of neutron star/black hole binary coalescences. DECIGO consists of four clusters of observatories placed in the heliocentric orbit. Each cluster consists of three spacecraft, which form three Fabry-Perot Michelson interferometers with an arm length of 1,000 km. Three clusters of DECIGO will be placed far from each other, and the fourth cluster will be placed in the same position as one of the three clusters to obtain the correlation signals for the detection of the primordial gravitational waves. We plan to launch B-DECIGO, which is a scientific pathfinder of DECIGO, before DECIGO in the 2030s to demonstrate the technologies required for DECIGO, as well as to obtain fruitful scientific results to further expand the multi-messenger astronomy.Comment: 10 pages, 3 figure

The status of DECIGO

DECIGO (DECi-hertz Interferometer Gravitational wave Observatory) is the planned Japanese space gravitational wave antenna, aiming to detect gravitational waves from astrophysically and cosmologically significant sources mainly between 0.1 Hz and 10 Hz and thus to open a new window for gravitational wave astronomy and for the universe. DECIGO will consists of three drag-free spacecraft arranged in an equilateral triangle with 1000 km arm lengths whose relative displacements are measured by a differential Fabry-Perot interferometer, and four units of triangular Fabry-Perot interferometers are arranged on heliocentric orbit around the sun. DECIGO is vary ambitious mission, we plan to launch DECIGO in era of 2030s after precursor satellite mission, B-DECIGO. B-DECIGO is essentially smaller version of DECIGO: B-DECIGO consists of three spacecraft arranged in an triangle with 100 km arm lengths orbiting 2000 km above the surface of the earth. It is hoped that the launch date will be late 2020s for the present

Current status of space gravitational wave antenna DECIGO and B-DECIGO

The Deci-hertz Interferometer Gravitational Wave Observatory (DECIGO) is a future Japanese space mission with a frequency band of 0.1 Hz to 10 Hz. DECIGO aims at the detection of primordial gravitational waves, which could have been produced during the inflationary period right after the birth of the Universe. There are many other scientific objectives of DECIGO, including the direct measurement of the acceleration of the expansion of the Universe, and reliable and accurate predictions of the timing and locations of neutron star/black hole binary coalescences. DECIGO consists of four clusters of observatories placed in heliocentric orbit. Each cluster consists of three spacecraft, which form three Fabry–Pérot Michelson interferometers with an arm length of 1000 km. Three DECIGO clusters will be placed far from each other, and the fourth will be placed in the same position as one of the other three to obtain correlation signals for the detection of primordial gravitational waves. We plan to launch B-DECIGO, which is a scientific pathfinder for DECIGO, before DECIGO in the 2030s to demonstrate the technologies required for DECIGO, as well as to obtain fruitful scientific results to further expand multi-messenger astronomy

Pressure Drop of a Refrigerant Flowing Vertically Upward and Downward in Small Circular, Rectangular, and Triangular Tubes

In the present study, experiments were performed to examine the characteristics of the two-phase frictional pressure drop of an R410A refrigerant flowing vertically upward and downward for the development of a high-performance heat exchanger using small tubes or mini-channels for air-conditioning systems. The cross-sections of copper test tubes were 0.5, 0.7, 1.0, 1.5, and 2.0 mm circular tubes, and rectangular and triangular tubes with hydraulic diameters of 1.04 and 0.88 mm, respectively. The frictional pressure drops were measured in the range of mass fluxes of 30–400 kg·m−2·s−1, with qualities from 0.05 to 0.9 and a saturation temperature of 10 °C. The characteristics of the measured pressure drops were compared in different inner diameters, cross-section shapes, and flow directions. In addition, Chisholm’s parameter and various modified Chisholm’s parameters for small tubes were examined to determine whether or not they reproduced our measurement data