Observation of a J^PC = 1-+ exotic resonance in diffractive dissociation of 190 GeV/c pi- into pi- pi- pi+

The COMPASS experiment at the CERN SPS has studied the diffractive dissociation of negative pions into the pi- pi- pi+ final state using a 190 GeV/c pion beam hitting a lead target. A partial wave analysis has been performed on a sample of 420000 events taken at values of the squared 4-momentum transfer t' between 0.1 and 1 GeV^2/c^2. The well-known resonances a1(1260), a2(1320), and pi2(1670) are clearly observed. In addition, the data show a significant natural parity exchange production of a resonance with spin-exotic quantum numbers J^PC = 1-+ at 1.66 GeV/c^2 decaying to rho pi. The resonant nature of this wave is evident from the mass-dependent phase differences to the J^PC = 2-+ and 1++ waves. From a mass-dependent fit a resonance mass of 1660 +- 10+0-64 MeV/c^2 and a width of 269+-21+42-64 MeV/c^2 is deduced.Comment: 7 page, 3 figures; version 2 gives some more details, data unchanged; version 3 updated authors, text shortened, data unchange

HM71224, a novel Bruton’s tyrosine kinase inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis in a mouse model: a potential drug for rheumatoid arthritis

BACKGROUND: Bruton’s tyrosine kinase (Btk) is critical for activation of B cells and myeloid cells. This study aimed to characterize the effects of HM71224, a novel Btk inhibitor, both in vitro and in a mouse model of experimental arthritis. METHODS: The kinase inhibition profile of HM71224 was analyzed. The in vitro effects of HM71224 on B cells and monocytes were analyzed by examining phosphorylation of Btk and its downstream signaling molecules, along with cytokine production and osteoclast formation. The in vivo effects of HM71224 were investigated in a mouse model of collagen-induced arthritis (CIA). RESULTS: HM71224 irreversibly bound to and inhibited Btk (IC(50) = 1.95 nM). The compound also inhibited the phosphorylation of Btk and its downstream molecules such as PLCγ2, in activated Ramos B lymphoma cells and primary human B cells in a dose-dependent manner. Furthermore, HM71224 effectively inhibited the production of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β by human monocytes, and osteoclast formation by human monocytes. Finally, HM71224 improved experimental arthritis and prevented joint destruction in a murine model of CIA. CONCLUSIONS: HM71224 inhibits Btk in B cells and monocytes and ameliorates experimental arthritis in a mouse model. Thus, HM71224 is a potential novel therapeutic agent for rheumatoid arthritis in humans. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13075-016-0988-z) contains supplementary material, which is available to authorized users

Hadron transverse momentum distributions in muon deep inelastic scattering at 160 GeV/c

Multiplicities of charged hadrons produced in deep inelastic muon scattering off a LiD target have been measured as a function of the DIS variables x , Q , W and the final state hadron variables p and z. The p distributions are fitted with a single exponential function at low values of p to determine the dependence of 〈p 〉 on x , Q , W and z. The z-dependence of 〈p 〉 is shown to be a potential tool to extract the average intrinsic transverse momentum squared of partons, 〈k 〉, as a function of x and Q in a leading order QCD parton model. 6 2 2 2 2 2 2 2 2 2 2 Bj T T T T Bj T ⊥ B

Hadron transverse momentum distributions in muon deep inelastic scattering at 160 GeV/c

Multiplicities of charged hadrons produced in deep inelastic muon scattering off a 6LiD target have been measured as a function of the DIS variables xBj , Q2, W2 and the final state hadron variables pT and z. The p2T distributions are fitted with a single exponential function at low values of p2T to determine the dependence of 〈p2T 〉 on xBj , Q2, W2 and z. The z-dependence of 〈p2T 〉 is shown to be a potential tool to extract the average intrinsic transverse momentum squared of partons, 〈k2⊥〉, as a function of xBj and Q2 in a leading order QCD parton model

Epidemiological applications of long-term stress in daily life.

The gluon polarisation in the nucleon has been determined by detecting charm production via D0 meson decay to charged K and \u3c0 in polarised muon scattering off a longitudinally polarised deuteron target. The data were taken by the COMPASS Collaboration at CERN between 2002 and 2006 and correspond to an integrated luminosity of 2.8 fb 121. The dominant underlying process of charm production is the photon\u2013gluon fusion to a_(c barc) pair. A leading order QCD approach gives an average gluon polarisation of _x= 120.49\ub10.27(stat)\ub10.11(syst) at a scale \u3bc^2 4813 (GeV/c)^2 and at an average gluon momentum fraction 480.11. The longitudinal cross-section asymmetry for D0 production is presented in bins of the transverse momentum and the energy of the D0 meson