Inhomogeneous superconductivity in thin crystals of FeSe1-xTex (x=1.0, 0.95, and 0.9)

We investigated the temperature dependence of resistivity in thin crystals of FeSe1-xTex (x = 1.0, 0.95, and 0.9), though bulk crystals with 1.0 x 0.9 are known to be non-superconducting. With decreasing thickness of the crystals, the resistivity of x = 0.95 and 0.9 decreases and reaches zero at a low temperature, which indicates a clear superconducting transition. The anomaly of resistivity related to the structural and magnetic transitions completely disappears in 55- to 155-nm-thick crystals of x = 0.9, resulting in metallic behavior in the normal state. Microbeam x-ray diffraction measurements were performed on bulk single crystals and thin crystals of FeSe1-xTex. A significant difference of the lattice constant, c, was observed in FeSe1-xTex, which varied with differing Te content (x), and even in crystals with the same x, which was mainly caused by inhomogeneity of the Se/Te distribution. It has been found that the characteristic temperatures causing the structural and magnetic transition (T-t), the superconducting transition (T-c), and the zero resistivity (T-c(zero)) are closely related to the value of c in thin crystals of FeSe1-xTex

Esophageal Adenocarcinoma Developing after Eradication of Helicobacter pylori

A 75-year-old man underwent endoscopic hemostatic therapy for hemorrhagic gastric ulcer in September 2002. After healing of the gastric ulcer, he underwent Helicobacter pylori eradication therapy in February 2003. In August 2007, an irregular tumor was detected in the lower esophagus at annual checkup for gastric cancer screening using X-ray. Endoscopic examination showed that the lower margin of the tumor almost coincided with the esophagogastric junction and that a short segment of Barrett's epithelium existed near the tumor. Biopsies of the tumor showed moderately to poorly differentiated adenocarcinoma. Mild reflux esophagitis and minor hiatal hernia was also observed, and the previously treated gastric ulcer was not recurrent. Absence of H. pylori was confirmed by serum antibody and urea breath test. Surgical resection of the lower esophagus and proximal stomach was performed. The tumor invaded into the muscularis propria of the esophageal wall but had no evidence of lymph node metastasis. Based on macroscopic and pathological findings, the tumor was recognized as esophageal adenocarcinoma. Previous endoscopic examination did not detect any apparent signs of tumor in the esophagogastric junction. As far as we know, this is the first report documenting a newly developed esophageal adenocarcinoma after the successful eradication of H. pylori

Signet Ring Cell Gastric Cancer Occurring after Radiation Therapy for Helicobacter pylori-Uninfected Mucosa-Associated Lymphoid Tissue Lymphoma

Helicobacter pylori infection is the major cause for mucosa-associated lymphoid tissue (MALT) lymphoma and gastric cancers. On the other hand, gastric cancers are known to arise from gastric mucosal atrophy. We here report a case of signet ring cell gastric cancer that developed after radiation therapy for MALT lymphoma in H. pylori-uninfected patient whose stomach did not show gastric mucosal atrophy. A 58-year-old female was referred to our hospital for treatment of gastric MALT lymphoma. This patient was not infected with H. pylori, and upper gastrointestinal endoscopy revealed that she did not have gastric mucosal atrophy but had submucosal tumor-like MALT lymphoma lesion in the anterior wall of the upper gastric body. Since conventional eradication therapy was ineffective, her whole stomach was irradiated as a second-line therapy. The MALT lymphoma lesion turned into complete remission state after the therapy. The patient was followed every 6 months by upper gastrointestinal endoscopy for 4 years as complete remission until a newly developed decolorized depressed lesion was detected in the greater curvature of the proximal antrum, a completely different location from the MALT lymphoma lesion. A biopsy specimen from the lesion contained signet ring cell carcinoma, and she was successfully treated by endoscopic submucosal dissection. No signs of recurrence have been detected so far. The radiation therapy for MALT lymphoma might be associated with the occurrence of this signet ring cell gastric cancer, and since MALT lymphoma is indolent in nature, this case suggests that careful consideration is required when choosing the second-line therapy for MALT lymphoma patients

スイートピー ノ ハナ ノ コウキ セイブン ノ ヒンシュカンサ

スイートピーの自生種,夏咲き系`Prima Donna\u27,春咲き系`Royal Rose\u27および冬咲き系`茅ケ崎11号\u27を供試して花の香気成分を調査した。花のヘッドスペースから自生種で86成分,`Prima Donna\u27で108成分,`Royal Rose\u27では90成分および`茅ケ崎11号\u27では116成分が,ヘキサン抽出物からは自生種で39成分,`Prima Donna\u27で49成分,`Royal Rose\u27では58成分および`茅ケ崎11号\u27では32成分が同定または推定された。これらの花の香気成分組成には品種間差が認められた。The volatile components of the floral fragrances in sweet pea cultivars ; native in Sicily, \u27Prima Donna\u27 (a summer flowering line), \u27Royal Rose\u27 (a spring flowering line) and \u27Chigasaki No. 11.\u27 (a winter flowering line) were determined using head space and solvent elution combined with gaschromatography-mass spectrometry. Total of 86 in the native species, 108 in \u27Prima Donna\u27, 90 components in \u27Royal Rose\u27, 116 in \u27Chigasaki No. 11.\u27 were identified from headspace of the flowers, and there were clear differences in the volatile composition of the flowers among the cultivars

キリバナヒンシツ ニ オヨボス ユリユニュウキュウ ノ ヒョウオンタイ デノ チョゾウ ト キカン ノ エイキョウ

オランダから輸入したオリエンタル系`カサブランカ\u27とLA系`セベコデジール\u27の球根を-0.5～-2.0℃の氷温帯で温度を変えて貯蔵し,定植期を変えて栽培した時の切り花品質を調査した。2003年3月18日から-1.5℃と-2.0℃で球根を約3,6,8,9,11か月間貯蔵した。ただし,-1.5℃貯蔵区は7月以降,約1か月ごとに温度を0.2℃ずつ上げていき,11月以降の貯蔵温度は-0.5℃一定とした。-2.0℃は一定であり,別に8か月貯蔵では,-1.5℃一定条件で貯蔵する区も設けた。栽培条件は最低夜温15℃とし,7～10月にかけて高温と強光を避けるために50%の寒冷紗を用いて遮光した。`カサブランカ\u27,`セベコデジール\u27ともに,-1.5℃貯蔵では6か月を過ぎると芽の伸長がみられ,りん片・茎のBrix値が低下した。-2.0℃貯蔵では11か月貯蔵後でも芽の伸長はほぼ抑制され,りん片・茎のBrix値低下も-1.5℃貯蔵に比べ小さかった。LT50値は,-2.0℃貯蔵では-1.5℃貯蔵よりも低く,貯蔵期間が長くなると高くなった。`カサブランカ\u27では,貯蔵期間が長くなるにつれて切り花の長さと重さおよび花数が減少する傾向にあった。また6か月以上貯蔵すると,異常花と障害葉の発生がみられ,異常花は-1.5℃貯蔵区で,障害葉は-2.0℃貯蔵区でより多く発生した。-1.5℃一定で貯蔵すると異常花の発生は減少したが,障害葉の発生は-2.0℃貯蔵と変わらなかった。これに対し,`セベコデジール\u27では貯蔵の温度・期間に関わらず切り花の長さと重さにはほとんど差がなく,遮光によるアボーションを除き,花と葉に障害の発生もほとんどみられなかった。以上の結果,オリエンタル系の`カサブランカ\u27では,球根を6か月以上氷温帯で貯蔵すると採花時の切り花品質が低下するが,LA系の`セベコデジール\u27では11か月氷温帯で貯蔵しても切り花品質への影響はほとんどないことが明らかになった。Lily bulbs of Oriental hybrid \u27Casa Blanca\u27 and LA hybrid \u27Ceb Dazzle\u27 imported from Holland were stored at -1.5℃, -1.5℃±0.3℃ or -2.0℃±0.5℃ for various durations from 3 to 11 months beginning on 18 March. At storage temperatures of -1.5℃, bulbs were stored at -1.5℃±0.5℃ from 18 March to early July and thereafter storage temperature was increased by 0.2℃ per month until reaching -0.5℃. After reaching -0.5℃, temperature was maintained at -0.5℃±0.5℃. At storage temperature of -1.5℃±0.3℃ bulbs were stored for only 8 months. After the storage, they were grown in a greenhouse kept at minimum temperature of 15℃ and under 50% shaded condition from July to October to check the quality of cut flowers. In bulbs of both cultivars stored at -1.5℃ for more than 6 months, shoots elongated and Brix values of scales and stems decreased. In contrast, at -2.0℃ elongation of shoots was inhibited and lowering of Brix values of scales and stems was smaller. Estimated median lethal temperature (LT50) of shoots was lower in bulbs stored at -2.0℃ than at -1.5℃ and became higher slightly with longer storage duration at both temperatures. In \u27Casa Blanca\u27 prolonged storage at any temperatures reduced the weight and length of cut flowers and the number of flowers. Longer storage for more than 6 months increased the number of abnormal flowers and damaged leaves. More abnormal flowers and damaged leaves were observed at -1.5℃ and -2.0℃, respectively. Storage at -1.5℃±0.3℃ reduced the number of abnormal flowers, but did not change the number of damaged leaves compared to -2.0℃. On the other hand, in \u27Ceb Dazzle\u27 length and weight of cut flowers were almost the same and abnormal flowers and damaged leaves were hardly observed irrespective of storage duration and temperatures. However, abortion of flowers occurred in October planting due to low light intensity under shading. These results show that \u27Casa Blanca\u27 bulbs cannot produce cut flowers with high quality after storage at temperatures below zero for more than 6 months, but \u27Ceb Dazzle\u27 bulbs can be stored up to 11 months

トウキョウ ノウギョウ ダイガク ガクセイ ガ ガクガイ ノウギョウ ケンキュウ ニ タイシテ キタイスル ヨウソ ノ トウケイガクテキ チュウシュツ

東京農業大学農学部にて開講されている，農業ビジネスデザインの受講学生を対象に，学生が学外農業研修で感じた「良かった点」の特徴を明らかにすることを目的として，自由記述によるアンケートを実施した。データ化した自由記述回答にテキストマイニングを施し，抽出した名詞の出現件数のデータに数量化Ⅲ類解析を施した。その結果，研修を主催する個人農家・企業，自治体，大学，の3属性によって，良かった点の内容が異なる1軸を含む3つの有効軸が算出された。本研究により，研修を受けた学生が現地に対して感じた良かった点は，‘人’および‘農家’の要素によって説明できると考えられた。これらの要素は同時に，農業志向の高い若者が農業研修に対して期待するものとして解釈することができると考えられ，今後，研修先との情報共有，意思疎通および研修内容の改善を通して，研修生と受け入れ先とのマッチングに役立てるなど，日本農業の担い手育成のためのPDCAサイクル化に大いに役立つと考えられた。A questionnaire based on free description was conducted with the aim of clarifying the features of “positive characteristics of the agricultural training course” that students felt through participating in agricultural training held outside the campus as part of “Studies for agricultural career design”, held at the Faculty of Agriculture, Tokyo University of Agriculture. The obtained responses were typed up and analyzed by text-mining method and multivariate analysis of the quantification theory type 3 was demonstrated on converted category (1/0) data based on the appearance of extracted nouns in answerers’ responses. As results, 3 axes including 1 axis where the mean value of the score according to the classification of the promoter mediating agricultural training courses significantly differed, were calculated. According to these results, the “positive characteristics of the agricultural training courses” that students felt, were might be summarized as the experience of “person” and “farmer”. It was also thought that these components could be interpreted as what expected of an agricultural experience program by the agriculture-minded young. In conclusion, findings in this study could be utilized as information sharing and communication tools in the training place for improvements in training contents, and would be useful for PDCA cycling, such as helping the match between students and training places, in developing agricultural human resources

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Immunohistochemical Localization of Epidermal Growth Factor in the Developing Rat Gonads

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