157 research outputs found
Spin Drift in Highly Doped n-type Si
A quantitative estimation of spin drift velocity in highly doped n-type
silicon (Si) at 8 K is presented in this letter. A local two-terminal Hanle
measurement enables the detection of a modulation of spin signals from the Si
as a function of an external electric field, and this modulation is analyzed by
using a spin drift-diffusion equation and an analytical solution of the
Hanle-type spin precession. The analyses reveal that the spin drift velocity is
linearly proportional to the electric field. The contribution of the spin drift
effect to the spin signals is crosschecked by introducing a modified nonlocal
four-terminal method.Comment: 16 pages, 3 figure
Molecular and Phenotypic Profiling for Precision Medicine in Pancreatic Cancer: Current Advances and Future Perspectives
Pancreatic cancer is the most common lethal malignancy, with little improvement in patient outcomes over the decades. The development of early detection methods and effective therapeutic strategies are needed to improve the prognosis of patients with this disease. Recent advances in cancer genomics have revealed the genetic landscape of pancreatic cancer, and clinical trials are currently being conducted to match the treatment to underlying mutations. Liquid biopsy-based diagnosis is a promising method to start personalized treatment. In addition to genome-based medicine, personalized models have been studied as a tool to test candidate drugs to select the most efficacious treatment. The innovative three-dimensional organoid culture platform, as well as patient-derived xenografts can be used to conduct genomic and functional studies to enable personalized treatment approaches. Combining genome-based medicine with drug screening based on personalized models may fulfill the promise of precision medicine for pancreatic cancer
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