Isospin-Violating Dark Matter with Colored Mediators

In light of positive signals reported by the CDMS-II Si experiment and the recent results of the LUX and SuperCDMS experiments, we study isospin-violating dark matter scenarios assuming that the interaction of the dark matter is mediated by colored particles. We investigate the phenomenology of the model, including collider searches, flavor and CP phenomenology. A minimal possible scenario includes scalar dark matter and new vector-like colored fermions with masses of O(1) TeV as mediators. Such a scenario may be probed at the 14 TeV LHC, while flavor and CP constraints are stringent and severe tuning in the couplings is unavoidable. We also found that, as an explanation of the CDMS-II Si signal, isospin-violating fermionic dark matter models with colored scalar mediators are disfavored by the LHC constraints.Comment: 22 pages, 2 figures. Added references. Published versio

Stellar cooling limits on light scalar boson revisited

We revisit the stellar cooling limits on the light scalar boson whose coupling to the Standard Model particles is described by its mixing with the Higgs boson. Strong constraints have been obtained from the electron-nucleus bremsstrahlung process and the resonant plasma effect in the medium. We find that the bremsstrahlung contribution from the electron and nucleus scattering is of similar magnitude to the plasma mixing effect including the off-resonant mixing. The constraints on the scalar coupling are found to be about three orders of magnitude weaker than the previous evaluations. For white dwarfs, the stellar cooling constraint is even more suppressed due to the Pauli blocking effect. We obtain limits on the Higgs-scalar mixing angle of $10^{-10}-10^{-9}$ in the region where the scalar mass is lighter than about 10 keV.Comment: 17 pages, 7 figures; updated figures and added some reference

In silico analysis of inner ear development using public whole embryonic body single-cell RNA-sequencing data

The inner ear comprises four epithelial domains: the cochlea, vestibule, semicircular canals, and endolymphatic duct/sac. These structures are segregated at embryonic day 13.5 (E13.5). However, these four anatomical structures remain undefined at E10.5. Here, we aimed to identify lineage-specific genes in the early developing inner ear using published data obtained from single-cell RNA-sequencing (scRNA-seq) of embryonic mice. We downloaded 5000 single-cell transcriptome data, named ‘auditory epithelial trajectory’, from the Mouse Organogenesis Cell Atlas. The dataset was supposed to include otic epithelial cells at E9.5–13.5. We projected the 5000 ​cells onto a two-dimensional space encoding the transcriptional state and visualised the pattern of otic epithelial cell differentiation. We identified 15 clusters, which were annotated as one of the four components of the inner ear epithelium using known genes that characterise the four different tissues. Additionally, we classified 15 clusters into sub-regions of the four inner ear components. By comparing transcriptomes between these 15 clusters, we identified several candidates of lineage-specific genes. Characterising these new candidate genes will help future studies about inner ear development

An inhibitory substance of glyceraldehyde 3-phosphate dehydrogenase in urine of diabetic patients

In urine of diabetics, a significantly great inhibitory activity of glyceraldehyde 3-phosphate dehydrogenase (GAP-Dehyd) was observed compared with that of normal subjects. The 0.2 ml of urine from 41 patients with diabetes mellitus inhibited 0.5 units of GAP-Dehyd by 27.2 +/- 3.0% (mean +/- S.E.M.), while that from 17 normal volunteers inhibited only by 9.0 +/- 1.0% (P less than 0.05). This inhibitory substance was extracted by 90% ethanol from diabetic urine and partially purified by anion exchange chromatography using Dowex-1 (HCOO type). The molecular weight of this substance was confirmed to be 100--300 daltons by an analysis on Biogel P-4 gel filtration chromatography. And analysis by thin layer chromatography using silicagel plate showed that this inhibitor was a ninhydrin reactive substance which has not been reported previously. From the above facts, it was assumed that the inhibitory substance of GAP-Dehyd in urine of diabetics was a new acidic compound of low molecular weight containing an amino residue in the molecule.</p

Effects of chemical composition and stereoregularity on phase-transition behaviors of aqueous solutions of copolymers composed of N-isopropylacrylamide and N-n-propylacrylamide

Radical copolymerizations of N-isopropylacrylamide (NIPAAm) and N-n-propylacrylamide (NNPAAm) in various ratios were carried out in toluene at –40 °C in the presence of 3-methyl-3-pentanol to prepare syndiotactic copolymers with racemo dyad contents of ca. 70%. It was revealed that copolymers containing more than 92.5 mol% NNPAAm units exhibited large phase-transition hysteresis of their aqueous solutions. Sequence analysis suggested that intramolecular hydrogen-bonding of contiguous NNPAAm units in syndiotactic stereosequences in the dehydrated state were responsible for induction of the large hysteresis

High-Gain Power Recycling of a Fabry Perot Michelson Interferometer for a Gravitational-Wave Antenna

Power recycling was implemented on a fully suspended prototype interferometer with arm lengths of 20 m. A wave-front-sensing technique for alignment control of the suspended mirrors was also implemented, which allowed for several hours of stable operation. A power-recycling gain of greater than 12 was achieved, a significant increase over the highest gain in a suspended mirror Fabry Perot Michelson interferometer reported to date

Strength Characteristics of Weathered Granite

Weathered granite, which widely distributed in Japan, was tested by a triaxial testing apparatus to investigate its mechanical properties in the consolidated-undrained condition. This rock, classified as a soft rock, causes much trouble in the construction of civil engineering structures. However, its mechanical behavior has not been studied enough to understand the strength characteristics. In this paper, it was found that the general behavior of the weathered granite was very similar to that of clay. The comparison between these materials has been discussed. The strength parameters were obtained from yield points which were defined by two different methods. The physical meanings of these yield points were also discussed