Some Comments on Double Insurance in Marine Insurance Act 1906

亀井利明教授古稀記念特

Distribution of Lithium Nitrite Injected into Concrete and Its ASR Suppression Effect

In this research, lithium nitrite was injected into ASR-deteriorated concrete specimens made with reactive aggregates in order to suppress further deterioration. The amount of injected lithium nitrite was set to three different levels, and the subsequent expansion behavior and area of lithium permeation were investigated. The area of permeation was checked using the coloring reagent TDI. It was found that the prescribed amount of lithium cannot be injected fully into the non-deteriorated specimens. When the lithium was injected at an early stage of deterioration, the area of permeation was small and the ASR suppression effect was small regardless of the injection amount. Also, the expansion reduction effect was evident when the lithium was injected into the considerably cracked concrete

Affectionless control by the same-sex parents increases dysfunctional attitudes about achievement

AbstractBackgroundThe affectionless control parenting has been associated with depression in recipients. The aim of this study was to examine the effect of this parenting style on dysfunctional attitudes predisposing to depression.MethodsThe subjects were 666 Japanese volunteers. Perceived parental rearing was evaluated by the Parental Bonding Instrument, which has the care and protection subscales. Parental rearing was classified into four types, i.e., optimal parenting (high care/low protection), affectionate constraint (high care/high protection), neglectful parenting (low care/low protection), and affectionless control (low care/high protection). Dysfunctional attitudes were evaluated by the 24-item Dysfunctional Attitude Scale, which has the achievement, dependency and self-control subscales.ResultsMales with paternal affectionless control had higher achievement scores than those with paternal optimal parenting (P=.016). Similarly, females with maternal affectionless control had higher achievement scores than those with maternal optimal parenting (P=.016).ConclusionThe present study suggests that affectionless control by the same-sex parents increases dysfunctional attitudes about achievement

Theoretical Analysis on the Stability of 1-Pyrenebutanoic Acid Succinimidyl Ester Adsorbed on Graphene

Oishi Y., Ogi H., Hagiwara S., et al. Theoretical Analysis on the Stability of 1-Pyrenebutanoic Acid Succinimidyl Ester Adsorbed on Graphene. ACS Omega 7, 31120 (2022); https://doi.org/10.1021/acsomega.2c03257.The adsorbed structure of 1-pyrenebutanoic acid succinimidyl ester (PASE) on graphene was investigated based on density functional theory. We found two locally stable structures: A straight structure with the chainlike part of butanoic acid succinimidyl ester (BSE) lying down and a bent structure with the BSE part directed away from graphene, keeping the pyrene (Py) part adsorbed on graphene. Then, to elucidate the adsorption mechanism, we separately estimated the contributions of the Py and BSE parts to the entire PASE adsorption, and the adsorption effect of the BSE part was found to be secondary in comparison to the contribution of the Py. Next, the mobility of the BSE part at room temperature was confirmed by the activation energy barrier between straight and bent structures. To take account of the external environment, we considered the presence of amino acids and the hydration effect by a three-dimensional reference interaction site model. The contributions of glycine molecules and the solvent environment to stabilizing the bent PASE structure relative to the straight PASE structure were found. Therefore, the effect of the external environment around PASE is of importance when the standing-up process of the BSE part from graphene is considered

Flexible Mono-tread Mobile Track (FMT) - A New Mobile Mechanism Using One Track and Vertebral Structure -

Non

Asymmetric alcoholytic kinetic resolution of styrene oxide catalysed by chiral metal-organic framework crystals

The methanolytic kinetic resolution of styrene oxide catalyzedby chiral metal–organic framework crystals afforded both2-methoxy-2-phenylethanol and unreacted styrene oxide in goodenantiomeric excesses

Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss

Sonehara K., Yano Y., Naito T., et al. Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss. Nature communications 15, 5744 (2024); https://doi.org/10.1038/s41467-024-49993-5.Recurrent pregnancy loss (RPL) is a major reproductive health issue with multifactorial causes, affecting 2.6% of all pregnancies worldwide. Nearly half of the RPL cases lack clinically identifiable causes (e.g., antiphospholipid syndrome, uterine anomalies, and parental chromosomal abnormalities), referred to as unexplained RPL (uRPL). Here, we perform a genome-wide association study focusing on uRPL in 1,728 cases and 24,315 female controls of Japanese ancestry. We detect significant associations in the major histocompatibility complex (MHC) region at 6p21 (lead variant=rs9263738; P = 1.4 × 10-10; odds ratio [OR] = 1.51 [95% CI: 1.33-1.72]; risk allele frequency = 0.871). The MHC associations are fine-mapped to the classical HLA alleles, HLA-C*12:02, HLA-B*52:01, and HLA-DRB1*15:02 (P = 1.1 × 10-10, 1.5 × 10-10, and 1.2 × 10-9, respectively), which constitute a population-specific common long-range haplotype with a protective effect (P = 2.8 × 10-10; OR = 0.65 [95% CI: 0.57-0.75]; haplotype frequency=0.108). Genome-wide copy-number variation (CNV) calling demonstrates rare predicted loss-of-function (pLoF) variants of the cadherin-11 gene (CDH11) conferring the risk of uRPL (P = 1.3 × 10-4; OR = 3.29 [95% CI: 1.78-5.76]). Our study highlights the importance of reproductive immunology and rare variants in the uRPL etiology