193 research outputs found
Stabilization of a honeycomb lattice of IrO octahedra in superlattices with ilmenite-type MnTiO
In the quest for quantum spin liquids, thin films are expected to open the
way for the control of intricate magnetic interactions in actual materials by
exploiting epitaxial strain and two-dimensionality. However, materials
compatible with conventional thin-film growth methods have largely remained
undeveloped. As a promising candidate towards the materialization of quantum
spin liquids in thin films, we here present a robust ilmenite-type oxide with a
honeycomb lattice of edge-sharing IrO octahedra artificially stabilized by
superlattice formation with an ilmenite-type antiferromagnetic oxide MnTiO.
The stabilized sub-unit-cell-thick Mn-Ir-O layer is isostructural to MnTiO,
having the atomic arrangement corresponding to ilmenite-type MnTiO not
discovered yet. By spin Hall magnetoresistance measurements, we found that
antiferromagnetic ordering in the ilmenite Mn sublattice is suppressed by
modified magnetic interactions in the MnO planes via the IrO planes.
These findings lay the foundation for the creation of two-dimensional Kitaev
candidate materials, accelerating the discovery of exotic physics and
applications specific to quantum spin liquids
Investigation of automotive light blinking pattern conveying a driver's intention to yield
This paper proposes a method of conveying a driver’s intention to yield by blinking automotive lighting. Generally, headlight flashing indicates a driver’s intention to yield to another driver or pedestrians in Japan. However, this signaling method can have several meanings, including warning other drivers of road dangers such as crashed cars, or informing other drivers of the presence of a pedestrian. There is a possibility of a misunderstanding, increasing the risk of accidents. Therefore, we have investigated an effective method for facilitating communication in traffic. This study focuses on nonverbal communication in which blinking lights convey the driver’s intentions to others. In this study, visibility is not considered. Nine blinking patterns that changed the light colors, waveform, and blinking cycle were presented to fifteen healthy participants, and visual impressions were evaluated to identify the most suitable blinking patterns. These nine patterns indicate a driver’s intention to yield to pedestrians and other drivers. The results indicated that a blue-green blinking pattern in which luminance changes with a triangular wave pattern with a one-second cycle was best conveyed the intention to yield
A METHOD FOR ESTIMATING ELBOW VARUS TORQUE USING ONLY A BASEBALL WITH AN EMBEDDED SENSOR
Currently, to measure the elbow varus torque during baseball pitching, it is necessary to attach markers and sensors to the body. The purpose of this study is to develop the method for estimating elbow varus torque by only a baseball with an embedded sensor, and examine the accuracy. Eight baseball pitchers threw a four-seam fastball with maximum effort. The varus torque was estimated using one-link-segment model by an accelerometer and gyro sensor placed in the baseball. The Intraclass Correlation Coefficients between the maximum values of the varus torque calculated by the proposed method and the values calculated by the motion capture system was high (ICC(3,1) = 0.73).This result indicates that proof of concept by one-link model is success and warrants future research to potentially develop a system with greater accuracy
Cetuximab plus FOLFOX for Patients with Metastatic Colorectal Cancer with Poor Performance Status and/or Severe Tumor-Related Complications
Introduction: Cetuximab-based chemotherapy showed a statistically significantly higher response rate compared with chemotherapy such as FOLFOX. Therefore, FOLFOX plus cetuximab is suspected to be the best regimen to alleviate tumor-related symptoms with a high response rate. Case Report: Here we present the results of 8 consecutive patients with metastatic colorectal cancer with poor performance status and/or severe complications who were treated with first-line FOLFOX with cetuximab. Six of 8 patients achieved an apparent clinical benefit, including radiological response and symptoms improvement. Two patients with BRAF mutation could achieve neither clinical benefit nor radiological response. Conclusion: Although an optimal line of therapy with cetuximab is unclear yet with bevacizumab in mind, we propose that patients who need a tumor response to alleviate their symptoms due to advanced disease might be candidates for first-line cetuximab-based therapy as shown in our cases. Additionally, patients with BRAF mutant tumors might be important candidates for novel targeted therapy in the future to improve their poor prognosis
A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues
Proteolysis-targeting chimaeras (PROTACs) as well as molecular glues such as immunomodulatory drugs (IMiDs) and indisulam are drugs that induce interactions between substrate proteins and an E3 ubiquitin ligases for targeted protein degradation. Here, we develop a workflow based on proximity-dependent biotinylation by AirID to identify drug-induced neo-substrates of the E3 ligase cereblon (CRBN). Using AirID-CRBN, we detect IMiD-dependent biotinylation of CRBN neo-substrates in vitro and identify biotinylated peptides of well-known neo-substrates by mass spectrometry with high specificity and selectivity. Additional analyses reveal ZMYM2 and ZMYM2-FGFR1 fusion protein—responsible for the 8p11 syndrome involved in acute myeloid leukaemia—as CRBN neo-substrates. Furthermore, AirID-DCAF15 and AirID-CRBN biotinylate neo-substrates targeted by indisulam and PROTACs, respectively, suggesting that this approach has the potential to serve as a general strategy for characterizing drug-inducible protein–protein interactions in cells
Temperature evolution of magnetic phases near the thickness-dependent metal-insulator transition in LaSrMnO thin films observed by XMCD
Perovskite-type manganites, which are well-known for their intriguing
physical properties such as colossal magnetoresistance (CMR) and half
metalicity, have been considered as candidate materials for spintronics.
However, their ferromagnetic (FM) properties are often suppressed in thin films
when the thickness is reduced down to several monolayers (MLs). In order to
investigate how the magnetic phases evolve near the paramagnetic (PM)-to-FM
phase transition boundary, we have performed temperature-dependent x-ray
magnetic circular dichroism (XMCD) experiments on a LaSrMnO
(LSMO, ) thin film, whose thickness (8 ML) is close to the boundary
between the FM-metallic and the PM-insulating phases. By utilizing the
element-selectiveness of XMCD, we have quantitatively estimated the fractions
of the PM and superparamagnetic (SPM) phases as well as the FM one as a
function of temperature. The results can be reasonably described based on a
microscopic phase-separation model.Comment: 6 pages, 3 figure
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