CLINICAL AND AUTOIMMUNE CHARACTERISTICS OF COVID-19 PATIENTS IN A TERTIARY CARE CENTRE: A CROSS-SECTIONAL STUDY

Introduction: Since the end of 2019, the world is witnessing the emergence of the coronavirus disease 2019 (COVID-19) outbreak and pandemic caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This disease presented with a wide array of clinical, inflammatory and possible autoimmune manifestations. Currently, a very few data is available about the involvement of autoimmunity in patients affected by coronavirus disease 2019 (COVID-19). Aim: To find out the clinical and inflammatory status of COVID-19 patients and whether this disease (SARS-CoV-2) stimulates autoantibody production and contributes to autoimmunity activation. Methodology: A hospital based retrospective study conducted on 60 COVID-19 patients. All patients were clinically and radiologically evaluated and screened for common inflammatory markers and auto antibodies. Result: Patients included were 39 men (65%) and 21 women (35%). 33 patients were mild cases, 15 were moderate and 12 were severe cases with a mean age of 44.27. Fever and shortness of breath were the dominant symptoms; most patients had at least one coexisting disorder on admission; the most common characteristic on chest CT was groundglass opacity; the most common findings on laboratory measurements of inflammatory markers were elevated levels of CRP, LDH ,ferritin and altered neutrophil lymphocyte ratio; and prevalence of autoantibodies ,anti SSA/Ro antibody, anti SSB/La antibody, and antinuclear antibody was 20%, 10%, and 15%, respectively and Anti-TPO antibody was positive in 33.3% patients. Conclusion: We conclude that autoimmune phenomena exist in COVID-19 subjects.

A STUDY ON CORRELATION OF PATTERN OF FEVER IN COVID 19 POSITIVE PA-TIENTS WITH CORRELATION TO BIOCHEMICAL PARAMETERS

Introduction: The novel coronavirus, SARS-CoV-2 presented with a wide array of clinical, inflammatory and radiological manifestations. Currently, a very few data is available about the relationship in between pattern of fever and biochemical parameters in patients affected by COVID-19. Our objective is to find out the clinical and inflammatory status of COVID-19 patients and whether there is a relationship in between pattern of fever and biochemical parameters of severe acute respiratory syndrome coronavirus disease 2. Methodology: A retrospective study conducted on 60 COVID-19 positive patients, who were clinically/ radiologically evaluated and screened for inflammatory markers. Result: 39 men and 21 women had Fever and elevated inflammatory markers like CRP, D-dimer, ferritin, ESR. Altered neutrophil lymphocyte ratio was also found. Patients with moderate and severe grade fever had more significant rise in CRP (60%), D-dimer (50%). patients with mild and moderate fever had more rise of ferritin (65%).ESR and NLR were not significantly increased. Patients with intermittent fever had high rise in CRP (80%), D-dimer (75%), and ferritin (72%). Again, ESR was not significantly raised. NLR was moderately raised in patients with continuous fever (66%). Sub acute and chronic rise of temperature shows more significant rise in CRP (60%), D-dimer (82%), ferritin (80%), NLR and ESR. Conclusion: Our study results shows that fever pattern in COVID-19 infection correlates with the inflammatory biochemical markers. Our study might be of help regarding early diagnosis of severity and timely intervention of COVID-19 infected patients to prevent morbidity and mortality

A STUDY ON IMPACT OF EDUCATION ON DIABETIC CONTROL AND COMPLICATIONS

Objective: To study the impact of educational level on the control of type 2 diabetes mellitus and subsequent development of its complications. Methods: Epidemiological Cross-sectional study conducted with 200 patients with Type 2 diabetes mellitus. The data were obtained from patients attending a Tertiary care hospital in Eastern India. Results: Glycemic control is better in more educated persons and level of education has an inverse relationship to the complication score. Percentage of patients with complication score more than 10 gradually decreases as the literacy level increases from 5th standard class onwards. Conclusion: Our study thus showed a positive impact of education on diabetes control and an inverse relationship with development of complications i.e. the more the education, the less the Diabetic complications

CLINICAL PROFILES OF DENGUE FEVER IN A TEACHING HOSPITAL OF EASTERN INDIA

Introduction: Dengue fever is one of the most common arbo virus mediated outbreaks, being reported from different parts of the world. Dengue fever (DF), Dengue hemorrhagic fever (DHF) and Dengue shock syndrome (DSS) are different modes of presentation of the disease. Now as the outbreaks are hitting different geographic locations, different clinical manifestations are more and more being reported recently. Our aim of this study is to document varied clinical manifestations of dengue patients in a tertiary care centre of eastern India. Materials and Methods: Total 74 MAC ELISA positive dengue patients are included in this observational study and analyzed. Results: Most common clinical feature was fever (100%) followed by headache (62.16%). Atypical features like transaminitis and different neurological manifestations were present in 83.83% and 11.11% cases respectively. Conclusion: One should aware of different atypical presentations of dengue fever to diagnose and intervene timely.

A STUDY ON LIPID PROFILES IN CHRONIC LIVER DISEASES

Background: Liver diseases can affect plasma lipid levels in a variety of ways. Chronic liver diseases due to various causes are often associated with dramatic reductions in plasma triglyceride and cholesterol level due to reduced lipoprotein biosynthetic capacity. The study was conducted to determine the lipid profiles in patients with chronic liver disease and to determine if it correlates with the severity of the chronic liver disease. Materials and Methods: In an analytical cross-sectional study, 120 patients with chronic liver disease (case) and 50 age- and sex-matched healthy patients (controls) were studied. Serum triglyceride levels, total cholesterol, HDL, LDL and VLDL were then measured. Child-Turcotte-Pugh Score were calculated for each patient as an index for the extent of liver damage. Results: In patients with chronic liver diseases, with the exception of triglyceride level, there was a significant decrease in total cholesterol, LDL,VLDL and HDL cholesterol levels compared to the control group( p<0.05). However, no significant correlation was found between severity of cirrhosis and change in serum lipid levels. Conclusion: Dyslipidemia exists in patients with liver cirrhosis and screening for the same is important for intervention with appropriate therapy to prevent cardiovascular events.