The design features of the body of the portable electrocardiograph "ECG-EXPRESS"

The sequence of the industrial product shaping is specified, the main modeling characteristics of the configuration and some of its parts are designated subject to the electrocardiograph design and the technologies used for the production of its body

LIF-Dependent Signaling: New Pieces in the Lego

LIF, a member of the IL6 family of cytokine, displays pleiotropic effects on various cell types and organs. Its critical role in stem cell models (e.g.: murine ES, human mesenchymal cells) and its essential non redundant function during the implantation process of embryos, in eutherian mammals, put this cytokine at the core of many studies aiming to understand its mechanisms of action, which could benefit to medical applications. In addition, its conservation upon evolution raised the challenging question concerning the function of LIF in species in which there is no implantation. We present the recent knowledge about the established and potential functions of LIF in different stem cell models, (embryonic, hematopoietic, mesenchymal, muscle, neural stem cells and iPSC). We will also discuss EVO-DEVO aspects of this multifaceted cytokine

Mathematical model of optimizing the arrival of fire units with the use of information systems for monitoring transport logistics of Voronezh city

In recent years, the strong pace of construction is increasing in big cities. With their growth becomes a question of the deployment of firefighters and the number of fire stations. The most effective solution is the problem of finding the optimum route of fire departments, taking into account the information transport logistics systems within the city that will allow us to arrive at the scene at any time, regardless of the degree of congestion of city roads. Prompt arrival of fire units provides the most successful fire fighting. The main objective of the study is to develop a preliminary route and the route in case of unforeseen factors affecting the time fire engine arrived. To construct the routes used to develop actively in the current methods of machine learning artificial neural networks. To construct the optimal route requires a correct prediction of the future behavior of a complex system of urban traffic based on its past behavior. Within the framework of statistical machine learning theory considered the problem of classification and regression. The learning process is to select a classification or a regression function of a predetermined broad class of such functions. After determining the prediction scheme, it is necessary to evaluate the quality of its forecasts, which are measured not on the basis of observations, and on the basis of an improved stochastic process, the result of the construction of the prediction rules. The model is verified on the basis of data collected in real departures real fire brigades, which made it possible to obtain a minimum time of arrival of fire units

Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway

In Biology Oriented Synthesis the scaffolds of biologically relevant compound classes inspire the synthesis of focused compound collections enriched in bioactivity. This criterion is met by the structurally complex scaffolds of natural products (NPs) selected in evolution. The synthesis of NP-inspired compound collections approaching the complexity of NPs calls for the development of efficient synthetic methods. We have developed a one pot 4–7 step synthesis of mono-, bi-, and tricyclic oxepanes that resemble the core scaffolds of numerous NPs with diverse bioactivities. This sequence entails a ring-closing ene-yne metathesis reaction as key step and makes productive use of polymer-immobilized scavenger reagents. Biological profiling of a corresponding focused compound collection in a reporter gene assay monitoring for Wnt-signaling modulation revealed active Wntepanes. This unique class of small-molecule activators of the Wnt pathway modulates the van-Gogh-like receptor proteins (Vangl), which were previously identified in noncanonical Wnt signaling, and acts in synergy with the canonical activator protein (Wnt-3a)

A small molecule accelerates neuronal differentiation in the adult rat

Adult neurogenesis occurs in mammals and provides a mechanism for continuous neural plasticity in the brain. However, little is known about the molecular mechanisms regulating hippocampal neural progenitor cells (NPCs) and whether their fate can be pharmacologically modulated to improve neural plasticity and regeneration. Here, we report the characterization of a small molecule (KHS101) that selectively induces a neuronal differentiation phenotype. Mechanism of action studies revealed a link of KHS101 to cell cycle exit and specific binding to the TACC3 protein, whose knockdown in NPCs recapitulates the KHS101-induced phenotype. Upon systemic administration, KHS101 distributed to the brain and resulted in a significant increase in neuronal differentiation in vivo. Our findings indicate that KHS101 accelerates neuronal differentiation by interaction with TACC3 and may provide a basis for pharmacological intervention directed at endogenous NPCs