The Synthesis and Antiviral Activities of 2-Substituted azino-3-B-D-rihofuranosyl and a and B-D-arahinofuranosyl-5-carbamoylmethylenethiazolidine-4-ones

2-(1-Isopropylidene and Methylbenzylidene)azino-B-n-ribofuranosyl- 5-carbamoylmethylenethiazolidine-4-one 3 were prepared by acid catalyzed fusion of 2-(1-Isopropylidene and 1-Methylbenzylidene) azino-5-carbamoylmethylenethiazolidine-(3H)-4-one 1, with 1-0-acetyl-2,3,5-tri-O-benzoyl-B-n-ribofuranose and from deri vative 7 through intermediates 9 and 10, subsequent ringclosure to 11 and final deprotection. a and B-arabino furanosyl derivatives were synthesised using a direct amminolysis of protected derivative 5. All derivatives are totally inactive against herpes simplex virus, while showing moderate activity against poliovirus 2

Complex Formation Between the Antiviral Nucleoside Ribavirin (1-·B-D-Ribofuranosyl-1,2,4-Triazole-3-Carboxamide) and Bivalent Metal Ions: 1H and 13C NMR Studies, and Comparison with Inosine

The interactions O\u27f metal chlorides (MeClz) of group !La (Me = Mg, Ca, Sr, Ba) and group !lb (Me = Zn, Cd, Hg) with ribavi.rin, a potent broad spectrum antiviral nucleoside, and with .Us structural analogue inosine were studied in DMSO-ds using 1H and 130 NMR methods. Proton limiting shift analysis was made and 1H and 130 spin lattice relaxation times oif ribavirin as a function o:f metal ion concentrations were determined. The nature of the interactions was determined on the basis of these data. The composition 01f comple1xes was determined using J0<b-plo.ts as 1 : 1 and the formation constants o·f 1 : 1 Me2+ -ribavirin and Me2+-inosine complexoo in equilibrium were evaluated either by concentration dependence or by a variaible temperature method

Synthesis of 8-Aza-3-deazaisoguanosine by a Novel Ring Closure of Dinitriles by Sodium Alkoxides

This communication describes a convenient, direct ring closure of a novel 4-cyano-5-cyanomethyl-1-(&beta;-D-ribofuranosyl)-1,2,3-triazole under basic conditions into 4-amino-6-alkoxy-1-(&beta;-D-ribofuranosyl)-1,2,3-triazolo[4,5-c]pyridine, which can be easily transformed to 8-aza-3-deazaisoguanosine

The Synthesis and Hybridization Studies of Oligodeoxyribonucleotides Containing the 2\u27-Deoxyguanosine Modification, 8-Aza-3-deaza-2\u27-deoxyguanosine

Chemical and physical properties of the modified nucleoside 8-aza-3-deaza-2’-deoxyguanosine (1) are described. From the amino protected nucleoside 1a, phosphoramidite 3 was prepared, and oligo-deoxyribonucleotides were synthesized. Duplexes containing compound 1 are slightly less stable than the natural duplex