Endometrial Cancer Diagnosed by the Presence of Bone Metastasis and Treated with Zoledronic Acid: A Case Report and Review of the Literature

Bone metastasis from endometrial cancer is rare. We report a case of endometrial cancer which was diagnosed by the presence of bone metastasis and treated with zoledronic acid. A 57-year-old woman complaining of progressive right hip pain consulted an orthopedist. She had no gynecologic complaints. X-rays revealed an osteolytic lesion of the right ischium. Bone scintigraphy was subsequently carried out and showed isotope accumulation in the right ischium. Computed tomography revealed an enlarged uterus; the patient consequently consulted a gynecologist. Histological sections of an endometrial biopsy showed endometrioid adenocarcinoma. Hysterectomy and bilateral salpingo-oophorectomy, as well as bone biopsy of the right ischium, were therefore carried out. A moderately differentiated endometrioid adenocarcinoma was expressed in the corpus. Histopathological examination of the bone biopsy also revealed adenocarcinoma. The final diagnosis was stage IVB endometrial cancer with bone and lung metastasis. Good pain relief was achieved due to chemotherapy. However, 2 months after completion of the chemotherapy, the patient was administered zoledronic acid because her hip pain had gradually increased. Following zoledronic acid administration, the hip pain reduced. Radiotherapy was then given for the right ischial metastasis after the ninth course of zoledronic acid therapy because the metastasis site had increased and the possibility of a pathological fracture had risen. However, the patient died 21 months after the initial treatment because of disease progression

Cryptococcal pleural effusion in an HTLV-I carrier with Waldenstroem's macroglobulinemia.

A 70-year-old woman with Waldenstroem's macroglobulinemia developed bilateral pleural effusions due to Cryptococcus neoformans. She was found to be a carrier of HTLV-I. It is speculated that the opportunistic infection occurred as the result of an impaired cellular immunity secondary to HTLV-I infection.</p

The Gauged Vector Model in Four-Dimensions: Resolution of an Old Problem?

A calculation of the renormalization group improved effective potential for the gauged U(N) vector model, coupled to $N_f$ fermions in the fundamental representation, computed to leading order in 1/N, all orders in the scalar self-coupling $\lambda$, and lowest order in gauge coupling $g^2$, with $N_f$ of order $N$, is presented. It is shown that the theory has two phases, one of which is asymptotically free, and the other not, where the asymptotically free phase occurs if $0 < \lambda /g^2 < {4/3} (\frac{N_f}{N} - 1)$, and $\frac{N_f}{N} < {11/2}$. In the asymptotically free phase, the effective potential behaves qualitatively like the tree-level potential. In the other phase, the theory exhibits all the difficulties of the ungauged $(g^2 = 0)$ vector model. Therefore the theory appears to be consistent (only) in the asymptotically free phase.Comment: Latex, 18 pages plus 3 figures using epsf. Substantially revised to correct a factor of 2 error in the previous version of equation (2.5b). This has significant effects on the results. The model has also been revised to include fermion

RR-Parity Violation in Flavor Changing Neutral Current Processes and Top Quark Decays

We show that supersymmetric $R$-parity breaking ($\not R_p$) interactions always result in Flavor Changing Neutral Current (FCNC) processes. Within a single coupling scheme, these processes can be avoided in either the charge $+2/3$ or the charge $-1/3$ quark sector, but not both. These processes are used to place constraints on \Rp couplings. The constraints on the first and the second generations are better than those existing in the literature. The \Rp interactions may result in new top quark decays. Some of these violate electron-muon universality or produce a surplus of $b$ quark events in $t\bar{t}$ decays. Results from the CDF experiment are used to bound these \Rp couplings.Comment: LaTeX, 20 pages, spelling corrected from origina

Leptonic and Semileptonic Decays of Charm and Bottom Hadrons

We review the experimental measurements and theoretical descriptions of leptonic and semileptonic decays of particles containing a single heavy quark, either charm or bottom. Measurements of bottom semileptonic decays are used to determine the magnitudes of two fundamental parameters of the standard model, the Cabibbo-Kobayashi-Maskawa matrix elements $V_{cb}$ and $V_{ub}$. These parameters are connected with the physics of quark flavor and mass, and they have important implications for the breakdown of CP symmetry. To extract precise values of $|V_{cb}|$ and $|V_{ub}|$ from measurements, however, requires a good understanding of the decay dynamics. Measurements of both charm and bottom decay distributions provide information on the interactions governing these processes. The underlying weak transition in each case is relatively simple, but the strong interactions that bind the quarks into hadrons introduce complications. We also discuss new theoretical approaches, especially heavy-quark effective theory and lattice QCD, which are providing insights and predictions now being tested by experiment. An international effort at many laboratories will rapidly advance knowledge of this physics during the next decade.Comment: This review article will be published in Reviews of Modern Physics in the fall, 1995. This file contains only the abstract and the table of contents. The full 168-page document including 47 figures is available at http://charm.physics.ucsb.edu/papers/slrevtex.p

CP-violation and unitarity triangle test of the Standard Model

Phenomenological issues of the CP violation in the quark sector of the Standard Model are discussed. We consider quark mixing in the SM, standard and Wolfenstein parametrization of the $CKM$ mixing matrix and unitarity triangle. We discuss the phenomenology of the CP violation in $K^{0}_{L}$ and $B_{d}^{0} (\bar B_{d}^{0})$-decays. The standard unitarity triangle fit of the existing data is discussed. In appendix A we compare the $K^{0}\leftrightarrows \bar K^{0}$, $B_{d,s}^{0}\leftrightarrows \bar B^{0}_{d,s}$ etc oscillations with neutrino oscillations. In Appendix B we derive the evolution equation for $M^{0}- \bar M^{0}$ system in the Weisskopf-Wigner approximation.Comment: On the basis of the lectures given to the students of SISSA (Trieste) in 200