413 research outputs found

    Withdrawal Note: Expression of Ski in the Follicles of eCG-primed Immature Hypophysectomized Rat Ovary

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    Effects of a deformable striking ship's bow on the structural crashworthiness in ship–ship collisions

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    Ship–ship collision accidents continue to occur regardless of the continuous efforts to prevent them, and they essentially involve highly nonlinear problems associated with structural crashworthiness due to crushing and fracture. The nonlinear finite-element method is one of the most powerful techniques to solve the problems. In industry practice, the bow structure of a striking ship is often modelled as a rigid body as it is usually much stiffer than the side structure of a struck ship. However, reality is that the initial kinetic energy in a ship–ship collision accident can be absorbed by the damages of not only the struck ship's side structures but also the striking ship's bow structures because the striking ship bow structure is actually deformable. The aim of the present study is to examine the effects of a deformable striking ship's bow on the structural crashworthiness in ship–ship collisions. In the present study, two scenarios are considered where the side structure of a VLCC class double hull oil tanker is collided by the bow structure of a VLCC class double hull oil tanker or a SUEZMAX class double hull oil tanker. All of the ships considered are real ships in operation. The structural crashworthiness in terms of the collision force–penetration relation and the collision energy–penetration relation is then studied with two cases in which the striking ship's bow structures are either rigid or deformable. It is concluded that the striking ship's bow may be modelled as a rigid body in minor collisions at a collision angle of about 90° where the initial kinetic energy is entirely consumed before the inner hull structure is ruptured, but it should be modelled as a deformable body in a major collision accident or at an inclined collision angle where the maximum penetration can be greater than the double side breadth

    A practical method to determine the dynamic fracture strain for the nonlinear finite element analysis of structural crashworthiness in ship–ship collisions

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    Ship–ship collisions continue to occur regardless of efforts to prevent them. The collisions involve highly nonlinear characteristics associated with structural crashworthiness, including crushing and fracture as well as buckling and plastic collapse. When applying nonlinear finite element analysis (NLFEA) to solve these problems, a reliable critical fracture strain accounting for strain-rate effects due to collision speed must be implemented. This study proposes a practical method to estimate the dynamic fracture strain to be used for the structural crashworthiness analysis associated with the collisions. For this purpose, the strain-rate characteristics in struck ship were investigated by NLFEA, in which the striking vessel was assigned various velocities in the range of practical ship speeds. Based on computations, an empirical formula was developed to calculate the strain rate at a given collision speed, allowing for a practical estimation of the dynamic fracture strain. The formula is validated by a comparison with experiment

    High-performance triazole-containing brush polymers via azide-alkyne click chemistry: a new functional polymer platform for electrical memory devices

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    Two series of well-defined brush polymers bearing a triazole moiety on each bristle were prepared from the click chemistry reactions of a poly(glycidyl azide) (PG) and a poly(4-azidomethylstyrene) (PS) with alkyne derivatives. The thin-film morphologies and properties, especially electrical memory performances, of these triazole-containing brush polymers were investigated in detail. The brush polymers with a triazole ring substituted with an alkyl or alkylenylphenyl group in the bristle exhibited only dielectric characteristics. By contrast, the other brush polymers bearing a triazole ring substituted with phenyl or its derivatives with a longer pi-conjugation length in the bristle demonstrated excellent unipolar permanent memory behaviors with low power consumption, high ON/OFF current ratios and high stability and reliability under ambient air conditions. Furthermore, their memory type could be tuned to p- or n-type by the incorporation of an electron-donating or -accepting group into the phenyl unit linked to the triazole moiety. Overall, this study presents the first demonstration of the azide-alkyne click chemistry synthesis of triazole moieties with substituent(s) that exhibit a resonance effect; this approach is a very powerful synthetic route to develop electrical memory polymers suitable for the low-cost mass production of high-performance, polarity-free programmable memory devices.111711Ysciescopu

    High Fidelity Tape Transfer Printing Based On Chemically Induced Adhesive Strength Modulation

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    Transfer printing, a two-step process (i.e. picking up and printing) for heterogeneous integration, has been widely exploited for the fabrication of functional electronics system. To ensure a reliable process, strong adhesion for picking up and weak or no adhesion for printing are required. However, it is challenging to meet the requirements of switchable stamp adhesion. Here we introduce a simple, high fidelity process, namely tape transfer printing(TTP), enabled by chemically induced dramatic modulation in tape adhesive strength. We describe the working mechanism of the adhesion modulation that governs this process and demonstrate the method by high fidelity tape transfer printing several types of materials and devices, including Si pellets arrays, photodetector arrays, and electromyography (EMG) sensors, from their preparation substrates to various alien substrates. High fidelity tape transfer printing of components onto curvilinear surfaces is also illustrated

    Architectural Growth of Cu Nanoparticles Through Electrodeposition

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    Cu particles with different architectures such as pyramid, cube, and multipod have been successfully fabricated on the surface of Au films, which is the polycrystalline Au substrate with (111) domains, using the electrodeposition technique in the presence of the surface-capping reagents of dodecylbenzene sulfonic acid and poly(vinylpyrrolidone). Further, the growth evolution of pyramidal Cu nanoparticles was observed for the first time. We believe that our method might open new possibilities for fabricating nanomaterials of non-noble transition metals with various novel architectures, which can then potentially be utilized in applications such as biosensors, catalysis, photovoltaic cells, and electronic nanodevices

    Review: optical fiber sensors for civil engineering applications

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    Optical fiber sensor (OFS) technologies have developed rapidly over the last few decades, and various types of OFS have found practical applications in the field of civil engineering. In this paper, which is resulting from the work of the RILEM technical committee “Optical fiber sensors for civil engineering applications”, different kinds of sensing techniques, including change of light intensity, interferometry, fiber Bragg grating, adsorption measurement and distributed sensing, are briefly reviewed to introduce the basic sensing principles. Then, the applications of OFS in highway structures, building structures, geotechnical structures, pipelines as well as cables monitoring are described, with focus on sensor design, installation technique and sensor performance. It is believed that the State-of-the-Art review is helpful to engineers considering the use of OFS in their projects, and can facilitate the wider application of OFS technologies in construction industry

    Hypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-the-art in vitro and mouse infection models

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    Hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC) worldwide. The prolyl hydroxylase domain (PHD)-hypoxia inducible factor (HIF) pathway is a key mammalian oxygen sensing pathway and is frequently perturbed by pathological states including infection and inflammation. We discovered a significant upregulation of hypoxia regulated gene transcripts in patients with chronic hepatitis B (CHB) in the absence of liver cirrhosis. We used state-of-the-art in vitro and in vivo HBV infection models to evaluate a role for HBV infection and the viral regulatory protein HBx to drive HIF-signalling. HBx had no significant impact on HIF expression or associated transcriptional activity under normoxic or hypoxic conditions. Furthermore, we found no evidence of hypoxia gene expression in HBV de novo infection, HBV infected human liver chimeric mice or transgenic mice with integrated HBV genome. Collectively, our data show clear evidence of hypoxia gene induction in CHB that is not recapitulated in existing models for acute HBV infection, suggesting a role for inflammatory mediators in promoting hypoxia gene expression

    Non-invasive assessment of coronary artery bypass graft patency using 16-slice computed tomography angiography

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    <p>Abstract</p> <p>Background</p> <p>Invasive coronary angiography is the gold standard means of imaging bypass vessels and carries a small but potentially serious risk of local vascular complications, including myocardial infarction, stroke and death. We evaluated computed tomography as a non-invasive means of assessing graft patency.</p> <p>Methods</p> <p>Fifty patients with previous coronary artery bypass surgery who were listed for diagnostic coronary angiography underwent contrast enhanced computed tomography angiography using a 16-slice computed tomography scanner. Images were retrospectively gated to the electrocardiogram and two dimensional axial, multiplanar and three dimensional reconstructions acquired. Sensitivity, specificity, positive and negative predictive value, accuracy and level of agreement for detection of graft patency by multidetector computed tomography.</p> <p>Results</p> <p>A total of 116 grafts were suitable for analysis. The specificity of CT for the detection of graft patency was 100%, with a sensitivity of 92.8%, positive predictive value 100%, negative predictive value 85.8% and an accuracy of 94.8%. The kappa value of agreement between the two means of measuring graft patency was 0.9. Mean radiation dose was 9.0 ± 7.2 mSv for coronary angiography and 18.5 ± 4 mSv for computed tomography. Pooled analysis of eight studies, incorporating 932 grafts, confirmed a 97% accuracy for the detection of graft patency by multidetector computed tomography.</p> <p>Conclusion</p> <p>Computed tomography is an accurate, rapid and non-invasive method of assessing coronary artery bypass graft patency. However, this was achieved at the expense of an increase in radiation dose.</p

    Airborne rhinovirus detection and effect of ultraviolet irradiation on detection by a semi-nested RT-PCR assay

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    BACKGROUND: Rhinovirus, the most common cause of upper respiratory tract infections, has been implicated in asthma exacerbations and possibly asthma deaths. Although the method of transmission of rhinoviruses is disputed, several studies have demonstrated that aerosol transmission is a likely method of transmission among adults. As a first step in studies of possible airborne rhinovirus transmission, we developed methods to detect aerosolized rhinovirus by extending existing technology for detecting infectious agents in nasal specimens. METHODS: We aerosolized rhinovirus in a small aerosol chamber. Experiments were conducted with decreasing concentrations of rhinovirus. To determine the effect of UV irradiation on detection of rhinoviral aerosols, we also conducted experiments in which we exposed aerosols to a UV dose of 684 mJ/m(2). Aerosols were collected on Teflon filters and rhinovirus recovered in Qiagen AVL buffer using the Qiagen QIAamp Viral RNA Kit (Qiagen Corp., Valencia, California) followed by semi-nested RT-PCR and detection by gel electrophoresis. RESULTS: We obtained positive results from filter samples that had collected at least 1.3 TCID(50 )of aerosolized rhinovirus. Ultraviolet irradiation of airborne virus at doses much greater than those used in upper-room UV germicidal irradiation applications did not inhibit subsequent detection with the RT-PCR assay. CONCLUSION: The air sampling and extraction methodology developed in this study should be applicable to the detection of rhinovirus and other airborne viruses in the indoor air of offices and schools. This method, however, cannot distinguish UV inactivated virus from infectious viral particles
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