44 research outputs found
Reaction Outcome Critically Dependent on the Method of Workup: An Example from the Synthesis of 1Isoquinolones
No full textNew monoterpene-derived phosphinopyridine ligands and their application in the enantioselective iridium-catalyzed hydrogenation
No full textPyridine derivatives with a phosphine or phosphinite pendant (1–11) have been synthesized from (+)-α-pinene, (−)-isopinocampheol, and/or (+)-camphor via Kröhnke annulation or another annulation method as the key step for the construction of the pyridine nucleus. The iridium complex of 6 proved to catalyze hydrogenation of the prochiral unfunctionalized alkene 44 with 94% ee, whereas the complex of 2 was most efficient in the hydrogenation of the cinnamyl-type ester 45 (83% ee)
Synthesis of Enantiopure 1-Arylprop-2-en-1-ols and Their tert-Butyl Carbonates
No full textEnantiomerically pure 1-arylpropenols 8 have been prepared by resolution of the corresponding racemates, using the lipase formulation Novozyme 435. Deprotonation of the latter alcohols with n-BuLi, followed by derivatization with (t-BUO)(2)CO, afforded the corresponding carbonates 5. Optimization of the process is presented
Diastereoisomeric cationic π-allylpalladium-(P,C)-MAP and MOP complexes and their relationship to stereochemical memory effects in allylic alkylation
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An Approach toward the Triquinane-Type Skeleton via Reagent-Controlled Skeletal Rearrangements. A Facile Method for Protection−Deprotection of Organomercurials, Tuning the Selectivity of Wagner−Meerwein Migrations, and a New Route to Annulated Lactones
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Comparison of HPLC enantioseparation of substituted binaphthyls on CD-, polysaccharide- and synthetic polymer-based chiral stationary phases
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