5 research outputs found
Wegener's Granulomatosis Presenting with Pachymeningitis: Clinical and Imaging Remission by Rituximab
A 27-year-old woman
was admitted for intractable right-sided neck,
ear, and jaw pain with gradual development of
tinnitus and hearing loss. A cerebral MRI showed
meningo-dural enhancement, and additional
diagnostic workup revealed a right pulmonary
infiltrate and positive PR-3 ANCA. Biopsies from
nasal mucosa and lung showed chronic
inflammation with granuloma formation. Based on
these findings the patient was diagnosed with
Wegener's granulomatosis with
pachymeningitis. There was no clinical response
to oral Prednisolone and Cyclophosphamide, but
complete clinical and imaging remission was
achieved by adding Rituximab