Мирон Кордуба і Микола Андрусяк: до історії взаємин

У статті проаналізовано взаємини українських істориків М. Кордуби та М. Андрусяка, зокрема висвітлено їхні особисті та творчі контакти. Також подано погляди учених на проблеми розвитку української науки, діяльність НТШ та національне книговидання тощо. Охарактеризовано взаємне листування вчених. У додатку до статті вміщено епістолярій М. Кордуби та М. Андрусяка.В статье проанализированы взаимоотношения украинских историков М. Кордубы и Н. Андрусяка, представлены их взгляды на развитие украинской науки, национальное книгоиздание, деятельность Научного общества имени Шевченко во Львове. Охарактеризовано переписку ученых. В приложении к статье помещены письма М. Кордубы и Н. Андрусяка.The article analyzes relationships of the Ukrainian historians M.Korduba and M.Andrusyak, in particular it highlights their personal and professional contacts. Also, the views of scientists on the problems of the Ukrainian science development, activities of Shevchenko Scientific Society and the national book publishing, etc. are given. The correspondence of two scientists is characterized. Correspondence of M. Korduba and M. Andrusiak is given in the appendix to the article

Catalan Abstracts

OBJECTIVE: This retrospective study addresses the cost-effectiveness of add-on therapy with lamotrigine in clinical practice. METHODS: Two years' observational data of 165 patients were used. Seizure frequency, adverse effects and direct medical costs were recorded for the year before and the year after the start of lamotrigine add-on therapy. Therapy effectiveness was measured by: (1) reduction in seizure frequency and (2) retention time. The incremental cost-effectiveness ratio expressed the direct medical cost per patient treated effectively with lamotrigine. RESULTS: The cost of medication was 492 (95% CI: 399-583) higher after the start of lamotrigine therapy. The extra cost of lamotrigine therapy (622) was partly offset by a reduction of the cost of co-medication (-130; 95% CI: -210 to -50). Overall, the total medical cost was 453 higher in the first year of lamotrigine therapy than in the year before the start of lamotrigine. Lamotrigine was effective in 47% of all the patients, making the resultant incremental cost-effectiveness ratio 954 per year. DISCUSSION: Add-on therapy of lamotrigine for patients with uncontrolled epilepsy offers improved health outcomes. Lamotrigine therapy is associated with increased cost (453) and an annual incremental cost-effectiveness ratio of 954. These data, together with utility data published in the literature, support the notion that lamotrigine should be considered as an add-on therapy in for patients with refractory epilepsy

Assessment of the value of lamotrigine in daily practice.

Contains fulltext : 48205.pdf (publisher's version ) (Open Access)RU Radboud Universiteit Nijmegen, 11 november 2005Promotores : Hekster, Y.A., Renier, W.O., Egberts, A.C.G. Co-promotores : Keyser, A.J.M., Deckers, C.L.P.221 p

Effectiveness of lamotrigine in daily practice: a multicentre chart review.

Contains fulltext : 58618.pdf (publisher's version ) (Closed access

Non-compliance on the part of the professional community with a national guideline: an argumentative policy analysis.

Contains fulltext : 49576.pdf (publisher's version ) (Closed access)In 1997, the National Health Insurance Board of the Netherlands (CVZ) introduced a guideline for the use of a new anti-epileptic drug, Lamotrigine. The goal was to limit the use of this relatively expensive drug to patients with difficult-to-treat epilepsy. A survey had shown that only a minority of neurologists were familiar with the guideline, and even fewer applied it in practice. In the present study, interviews were held with stakeholders to obtain a better understanding of why this policy measure failed. The results indicate that the problem definitions of policy maker and practicing neurologists differed widely, and that the policy measure was conflicting with certain professional beliefs. In such cases, the theory of argumentative policy predicts that policy is unlikely to succeed, unless policy makers take actions to ensure a greater congruence in interpretative frames between them and their target population

De invloed van nieuwe anti-epileptica op omvang en kosten van farmaceutische zorg.

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