Stellar laboratories. IX. New Se V, Sr IV - VII, Te VI, and I VI oscillator strengths and the Se, Sr, Te, and I abundances in the hot white dwarfs G191-B2B and RE 0503-289

To analyze spectra of hot stars, advanced non-local thermodynamic equilibrium (NLTE) model-atmosphere techniques are mandatory. Reliable atomic data is for the calculation of such model atmospheres. We aim to calculate new Sr IV - VII oscillator strengths to identify for the first time Sr spectral lines in hot white dwarf (WD) stars and to determine the photospheric Sr abundances. o measure the abundances of Se, Te, and I in hot WDs, we aim to compute new Se V, Te VI, and I VI oscillator strengths. To consider radiative and collisional bound-bound transitions of Se V, Sr IV - VII, Te VI, and I VI in our NLTE atmosphere models, we calculated oscillator strengths for these ions. We newly identified four Se V, 23 Sr V, 1 Te VI, and three I VI lines in the ultraviolet (UV) spectrum of RE0503-289. We measured a photospheric Sr abundance of 6.5 +3.8/-2.4 x 10**-4 (mass fraction, 9500 - 23800 times solar). We determined the abundances of Se (1.6 +0.9/-0.6 x 10**-3, 8000 - 20000), Te (2.5 +1.5/-0.9 x 10**-4, 11000 - 28000), and I (1.4 +0.8/-0.5 x 10**-5, 2700 - 6700). No Se, Sr, Te, and I line was found in the UV spectra of G191-B2B and we could determine only upper abundance limits of approximately 100 times solar. All identified Se V, Sr V, Te VI, and I VI lines in the UV spectrum of RE0503-289 were simultaneously well reproduced with our newly calculated oscillator strengths.Comment: 26 pages, 5 figure

Continuous combined microwave and hot air treatment of apples for fruit fly (Bactrocera tryoni and B. jarvisi) disinfestation

Apples at 24 ± 2 °C were heated in a pilot scale hot air assisted (40 °C) continuous pentagonal microwave system, to evaluate the effectiveness of this treatment on insect mortality (variety Mutsu) and fruit quality (variety Granny Smith). An average temperature of 53.4 ± 1.3 °C at core, bottom and flesh of the apple was recorded at the end of the treatment. One hundred percent mortality of the most tolerant stage of Queensland fruit fly (Bactrocera tryoni, Froggatt) and Jarvis's fruit fly (Bactrocera jarvisi, Tryon), were observed when the Mortality value (M52, equivalent time of isothermal treatment at 52 °C) at the slowest heating point applicable for each experiment was ≥ 50 min and ≥ 37 min, respectively. Results showed that microwave heat treatment is effective for insect disinfestation without any adverse impact on total soluble solids, flesh or peel firmness of the treated apples. The treated apples recorded a significantly higher pH and lower ion leakage than the untreated apples after 3 or 4 weeks. Therefore, the microwave heat treatment has the potential to be developed as an alternative chemical free quarantine treatment against economically significant insect pests. Industrial relevance Hot air assisted microwave heating of fruits and vegetables, is more cost effective compared to vapour heat treatment and ionising radiation for disinfestation of insects. Microwave treatment is environmentally friendly compared to fumigation and chemical treatments. Hot air assisted microwave disinfestation can be performed at farms or centralised pack houses since the capital cost would be comparatively lower than vapour heat or ionising radiation treatments

Modern microwave methods in solid state inorganic materials chemistry: from fundamentals to manufacturing

No abstract available

Verapamil and Acebutolol Overdose Results in Asystole: Intra-Aortic Balloon Pump Provides Mechanical Support

This is a case report of a 17-year-old woman who was in severe cardiogenic shock with intermittent consciousness due to an overdose of acebutolol and verapamil when paramedics arrived at her house. Two and one-half hours of CPR were required because she failed to respond to high doses of positive inotropes or to glucagon. A temporary pacemaker and intra-aortic balloon pump were used to provide hemodynamic support and hemoperfusion was used in an attempt to decrease serum levels of the cardiac-depressing drugs. This patient soon experienced complete recovery without sequelae

Aktuelle Praxis und Perspektiven beim CRO-Oversight für Biostatistik- & Data Management-Dienstleistungen - Umfrage unter den Mitgliedern des Verbandes Forschender Arzneimittelhersteller (vfa)

Outsourcing of activities is common and increasing in the pharmaceutical industry, not only for clinical trial conduct, or other trial related aspects but also for biostatistics and data management. This raises the question of whether and how sponsors retain the capability to select and to control the CRO(s) involved and what biometrical expertise still has to be present in the sponsor company to ensure adequate oversight. Not only in the case of partial outsourcing but especially in the case of complete outsourcing sponsors have to find the right balance between a complete "hands off" approach and a resource intensive in-house shadowing of activities to fulfil the requirements.In order to answer these questions, a survey was conducted among the German vfa member companies. This article discusses the specific oversight topics for the outsourcing of data management and biostatistics services, e.g. requirements for data quality, coding, and statistical analyses.This study shows that the majority of the companies use the same CRO for biometrical services as for rest of study services and that there is a preferred provider for these services in 65% of the companies. There are established, specific requirements for the main deliverables of biometrical services: For coding and data standards these are predominantly industry standards (MedDRA, CDISC). For statistic outputs and data quality mainly sponsor standards are used. The adherence to the requirements is mainly checked via spot-checks, and standardized checklists are mainly used for checking data standards. Generally, in all companies participating in the survey, there is an awareness of the necessity of biometrical oversight. Although not necessarily perfect yet, all companies took measures to ensure good biometrical oversight and there is a common understanding, that it is not an option to resign from biometrical oversight.Auslagerung ("Outsourcing ") von Aktivitäten ist üblich und nimmt in der pharmazeutischen Industrie weiter zu - dies trifft nicht nur für die Durchführung von klinischen Studien, sondern insbesondere auch für Biostatistik- und Datenmanagement-Dienstleistungen zu.Dies wirft die Frage auf, ob und wie Sponsoren die Möglichkeit behalten, CROs adäquat auszuwählen und zu kontrollieren und welche biometrische Expertise noch beim Sponsor vorhanden sein muss, um eine angemessene "Oversight " sicher zu stellen. Nicht nur im Falle der partiellen Auslagerung, sondern vor allem im Falle der kompletten Auslagerung müssen Sponsoren die richtige Balance zwischen einem kompletten unkontrollierten Überlassen aller Aktivitäten und einer Ressource-intensiven Wiederholung aller Aktivitäten finden, um ihrer Sponsoren-Verpflichtung gerecht zu werden.Um diese Fragen zu beantworten, wurde eine Umfrage unter den deutschen vfa-Mitgliedsunternehmen durchgeführt. Dieser Artikel beschreibt die spezifischen Oversight -Themen für die Auslagerung von Diensten aus den Bereichen Data Management und Biostatistik; es geht somit um Anforderungen hinsichtlich Datenqualität, Codierung und statistischer Analysen. Diese Studie zeigt, dass die Mehrheit der Unternehmen die gleichen CROs für biometrische Dienstleistungen wie für andere Dienstleistungen verwenden und dass es einen bevorzugten Anbieter ("preferred provider" ) für biometrische Dienstleistungen in 65% der Unternehmen gibt. Es gibt etablierte, spezifische Anforderungen für die Ergebnisse der biometrischen Dienstleistungen hinsichtlich Codierung und Daten-Standards (Industriestandards wie MedDRA und CDISC). Für die Darstellung der Ergebnisse von statistischen Analysen und für die Datenqualität werden vor allem Standards der Sponsoren verwendet. Die Einhaltung der Anforderungen wird vor allem auf Stichproben-Basis überprüft, während standardisierte Checklisten vorwiegend bei der Überprüfung von Datenstandards Anwendung finden. Grundsätzlich gibt es in allen Unternehmen, die an der Umfrage teilgenommen haben, ein Bewusstsein für die Notwendigkeit der biometrischen Aufsicht. Obwohl noch nicht überall unbedingt perfekt implementiert, ergreifen alle Unternehmen Maßnahmen, um eine gute biometrische Kontrolle zu gewährleisten. Es gibt ein gemeinsames Verständnis dafür, dass es keine Alternative zum effektiven biometrischen Oversight gibt