75 research outputs found
Three-dimensional medical printing and associated legal issues in plastic surgery: a scoping review
Three-dimensional printing (3DP) represents an emerging field of surgery. 3DP can facilitate the plastic surgeonâs workflow, including preoperative planning, intraoperative assistance, and postoperative follow-up. The broad clinical application spectrum stands in contrast to the paucity of research on the legal framework of 3DP. This imbalance poses a potential risk for medical malpractice lawsuits. To address this knowledge gap, we aimed to summarize the current body of legal literature on medical 3DP in the US legal system. By combining the promising clinical use of 3DP with its current legal regulations, plastic surgeons can enhance patient safety and outcomes
Pseudomorphic InGaAs base ballistic hotâelectron device
We report the first successful incorporation of a pseudomorphic InGaAs base in a ballistic hotâelectron device. The device, with a 28ânmâthick In0.15Ga0.85As base, had a collectorâbase breakdown voltage of 0.55 V and a maximum current transfer ratio of 0.89 at 4.2 K, considerably higher than the 0.75 in a comparable GaAsâbase device. Electron energy spectroscopy measurements revealed that at least 30% of the injected electrons traversed the InGaAs base ballistically, causing a strong modulation in the injected currents into the quantized base. The ÎâL valley separation in the strained In0.15Ga0.85As was estimated to be about 410 meV.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/71077/2/APPLAB-53-20-1946-1.pd
Three-dimensional Medical Printing and Associated Legal Issues in Plastic Surgery: A Scoping Review
Three-dimensional printing (3DP) represents an emerging field of surgery. 3DP can facilitate the plastic surgeonâs workflow, including preoperative planning, intraoperative assistance, and postoperative follow-up. The broad clinical application spectrum stands in contrast to the paucity of research on the legal framework of 3DP. This imbalance poses a potential risk for medical malpractice lawsuits. To address this knowledge gap, we aimed to summarize the current body of legal literature on medical 3DP in the US legal system. By combining the promising clinical use of 3DP with its current legal regulations, plastic surgeons can enhance patient safety and outcomes
Association of age with perioperative morbidity among patients undergoing surgical management of minor burns
INTRODUCTION: Burn injuries are associated with significant morbidity, often necessitating surgical management. Older patients are more prone to burns and more vulnerable to complications following major burns. While the relationship between senescence and major burns has already been thoroughly investigated, the role of age in minor burns remains unclear. To better understand differences between elderly and younger patients with predominantly minor burns, we analyzed a multi-institutional database.
METHODS: We reviewed the 2008-2020 ACS-NSQIP database to identify patients who had suffered burns according to ICD coding and underwent initial burn surgery.
RESULTS: We found 460 patients, of which 283 (62%) were male and 177 (38%) were female. The mean age of the study cohort was 46 ± 17 years, with nearly one-fourth (n = 108; 23%) of all patients being aged â„60 years. While the majority (n = 293; 64%) suffered from third-degree burns, 22% (n = 99) and 15% (n = 68) were diagnosed with second-degree burns and unspecified burns, respectively. An average operation time of 46 min, a low mortality rate of 0.2% (n = 1), a short mean length of hospital stay (1 day), and an equal distribution of in- and outpatient care (51%, n = 234 and 49%, n = 226, respectively) indicated that the vast majority of patients suffered from minor burns. Patients aged â„60 years showed a significantly prolonged length of hospital stay (p0.0001), creatinine (p>0.0001), white blood cell count (p=0.02), partial thromboplastin time (p = 0.004), and lower levels of albumin (p = 0.0009) and hematocrit (p>0.0001) were identified as risk factors for the occurrence of any complication. Further, complications were more frequent among patients with lower body burns.
DISCUSSION: In conclusion, patients â„60 years undergoing surgery for predominantly minor burns experienced significantly more complications. Minor lower body burns correlated with worse outcomes and a higher incidence of adverse events. Decreased levels of serum albumin and hematocrit and elevated values of blood urea nitrogen, creatinine, white blood count, and partial thromboplastin time were identified as predictive risk factors for complications
Vortex Motion Noise in Micrometre-Sized Thin Films of the Amorphous Nb0.7Ge0.3 Weak-Pinning Superconductor
We report high-resolution measurements of voltage (V) noise in the mixed
state of micrometre-sized thin films of amorphous Nb0.7Ge0.3, which is a good
representative of weak-pinning superconductors. There is a remarkable
difference between the noise below and above the irreversibility field Birr.
Below Birr, in the presence of measurable pinning, the noise at small applied
currents resembles shot noise, and in the regime of flux flow at larger
currents decreases with increasing voltage due to a progressive ordering of the
vortex motion. At magnetic fields B between Birr and the upper critical field
Bc2 flux flow is present already at vanishingly small currents. In this regime
the noise scales with (1-B/Bc2)^2 V^2 and has a frequency (f) spectrum of 1/f
type. We interpret this noise in terms of the properties of strongly driven
depinned vortex systems at high vortex density.Comment: 8 pages, 5 figures, version accepted for publication in PR
Evidence of Vortices on the Insulating Side of the Superconductor-Insulator Transition
The magnetoresistance of ultrathin insulating films of Bi has been studied
with magnetic fields applied parallel and perpendicular to the plane of the
sample. Deep in the strongly localized regime, the magnetoresistance is
negative and independent of field orientation. As film thicknesses increase,
the magnetoresistance becomes positive, and a difference between values
measured in perpendicular and parallel fields appears, which is a linear
function of the magnetic field and is positive. This is not consistent with the
quantum interference picture. We suggest that it is due to vortices present on
the insulating side of the superconductor-insulator transition.Comment: 4 pages, 3 figure
Association of age with perioperative morbidity among patients undergoing surgical management of minor burns
Introduction: Burn injuries are associated with significant morbidity, often necessitating surgical management. Older patients are more prone to burns and more vulnerable to complications following major burns. While the relationship between senescence and major burns has already been thoroughly investigated, the role of age in minor burns remains unclear. To better understand differences between elderly and younger patients with predominantly minor burns, we analyzed a multi-institutional database.
Methods: We reviewed the 2008-2020 ACS-NSQIP database to identify patients who had suffered burns according to ICD coding and underwent initial burn surgery.
Results: We found 460 patients, of which 283 (62%) were male and 177 (38%) were female. The mean age of the study cohort was 46 ± 17 years, with nearly one-fourth (n = 108; 23%) of all patients being aged â„60 years. While the majority (n = 293; 64%) suffered from third-degree burns, 22% (n = 99) and 15% (n = 68) were diagnosed with second-degree burns and unspecified burns, respectively. An average operation time of 46 min, a low mortality rate of 0.2% (n = 1), a short mean length of hospital stay (1 day), and an equal distribution of in- and outpatient care (51%, n = 234 and 49%, n = 226, respectively) indicated that the vast majority of patients suffered from minor burns. Patients aged â„60 years showed a significantly prolonged length of hospital stay (p0.0001), creatinine (p>0.0001), white blood cell count (p=0.02), partial thromboplastin time (p = 0.004), and lower levels of albumin (p = 0.0009) and hematocrit (p>0.0001) were identified as risk factors for the occurrence of any complication. Further, complications were more frequent among patients with lower body burns.
Discussion: In conclusion, patients â„60 years undergoing surgery for predominantly minor burns experienced significantly more complications. Minor lower body burns correlated with worse outcomes and a higher incidence of adverse events. Decreased levels of serum albumin and hematocrit and elevated values of blood urea nitrogen, creatinine, white blood count, and partial thromboplastin time were identified as predictive risk factors for complications
Phase II Study of Cetuximab in Combination with Docetaxel in Patients with Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck after Platinum-Containing Therapy: A Multicenter Study of the Arbeitsgemeinschaft Internistische Onkologie
Background: Cetuximab and docetaxel have single-agent activity in squamous cell carcinoma of the head and neck (SCCHN). The efficacy of their combination was evaluated in platinum-pretreated patients with recurrent and/or metastatic SCCHN. Patients and Methods: A total of 84 patients were treated with docetaxel 35 mg/m2 weekly for a maximum of 6 cycles and concomitant cetuximab 250 mg/m2 weekly until disease progression or unacceptable toxicity. The primary endpoint was the objective response rate and secondary endpoints included the response rate in relation to platinum sensitivity, progression-free survival (PFS), overall survival (OS) and toxicity. Results: Nine (11%) patients achieved a partial response and 34 (40%) stable disease, resulting in a disease control rate of 51%. Response to treatment was 49% in previously platinum-sensitive and 50% in previously platinum-resistant disease. The median PFS was 3.1 months and the median OS 6.7 months. The most common grade 3 or 4 adverse events were mucositis (8%), pneumonia (8%), fatigue (8%) and skin reactions (14%). Sepsis occurred in 3 patients. Conclusion: Cetuximab plus docetaxel is an active treatment regimen with moderate toxicity in SCCHN patients. However, no superiority in comparison with monotherapy could be shown. Responsiveness and survival were independent of previous platinum sensitivity
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