21 research outputs found
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ Π»ΠΎΠΌΠ±Π°ΡΠ΄Π½ΠΎΠΉ ΠΈΠ½Π΄ΡΡΡΡΠΈΠΈ Π½Π° ΡΡΠ½ΠΎΠΊ ΠΏΠΎΡΡΠ΅Π±ΠΈΡΠ΅Π»ΡΡΠΊΠΎΠ³ΠΎ ΠΊΡΠ΅Π΄ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ ΡΠΈΠ½Π°Π½ΡΠΎΠ²ΠΎΠ³ΠΎ ΠΊΡΠΈΠ·ΠΈΡΠ°
ΠΠ΅ΡΠ°Π»ΡΠ½ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ Π»ΠΎΠΌΠ±Π°ΡΠ΄Π½ΠΎΠΉ ΠΈΠ½Π΄ΡΡΡΡΠΈΠΈ Π² Π ΠΎΡΡΠΈΠΈ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½Π°Ρ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° Π»ΠΎΠΌΠ±Π°ΡΠ΄Π½ΠΎΠ³ΠΎ ΠΈ Π±Π°Π½ΠΊΠΎΠ²ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΡΡΠ΅Π±ΠΈΡΠ΅Π»ΡΡΠΊΠΎΠ³ΠΎ ΠΊΡΠ΅Π΄ΠΈΡΠ° Π² ΠΏΠ΅ΡΠΈΠΎΠ΄ ΡΠΈΠ½Π°Π½ΡΠΎΠ²ΠΎΠ³ΠΎ ΠΊΡΠΈΠ·ΠΈΡΠ°, Π²ΡΡΠ²Π»Π΅Π½Ρ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° ΠΈ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΈ Π»ΠΎΠΌΠ±Π°ΡΠ΄Π½ΠΎΠ³ΠΎ ΠΊΡΠ΅Π΄ΠΈΡΠΎΠ²Π°Π½ΠΈΡ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π»ΠΎΠΌΠ±Π°ΡΠ΄Ρ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Π²Π»ΠΈΡΡΡ Π½Π° ΡΡΠ½ΠΎΠΊ ΠΏΠΎΡΡΠ΅Π±ΠΈΡΠ΅Π»ΡΡΠΊΠΎΠ³ΠΎ ΠΊΡΠ΅Π΄ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΡΠΎΡΡΠ°Π²Π»ΡΡΡ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ ΠΊΠΎΠ½ΠΊΡΡΠ΅Π½ΡΠΈΡ ΠΊΠΎΠΌΠΌΠ΅ΡΡΠ΅ΡΠΊΠΈΠΌ Π±Π°Π½ΠΊΠ°ΠΌ. ΠΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½Π° Π²ΠΎΠ·ΡΠΎΡΡΠ°Ρ ΡΠΎΠ»Ρ Π»ΠΎΠΌΠ±Π°ΡΠ΄ΠΎΠ² ΠΊΠ°ΠΊ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΡ
ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·Π°ΡΠΎΡΠΎΠ²
ΠΠΎΠ²ΡΠΎΡΠ΅Π½ΠΈΡ Π½Π°ΡΡΠ½ΡΡ ΠΎΡΠΊΡΡΡΠΈΠΉ Π² ΠΊΠΎΠ½ΡΠ΅ΠΊΡΡΠ΅ ΠΈΠ΄Π΅ΠΉ ΠΈΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΏΠΈΡΡΠ΅ΠΌΠΎΠ»ΠΎΠ³ΠΈΠΈ
ΠΠ½Π°Π»ΠΈΠ·ΠΈΡΡΡΡΡΡ ΠΏΡΠΈΠΌΠ΅ΡΡ ΠΏΠΎΠ²ΡΠΎΡΠ΅Π½ΠΈΠΉ Π½Π°ΡΡΠ½ΡΡ
ΠΎΡΠΊΡΡΡΠΈΠΉ Π² ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ ΠΈΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠ΅ΡΠΈΠΎΠ΄Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π½Π°ΡΡΠ½ΠΎΠ³ΠΎ Π·Π½Π°Π½ΠΈΡ Π² ΠΊΠΎΠ½ΡΠ΅ΠΊΡΡΠ΅ ΠΈΠ΄Π΅ΠΉ ΠΈΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΏΠΈΡΡΠ΅ΠΌΠΎΠ»ΠΎΠ³ΠΈΠΈ. ΠΠ΅Π»Π°Π΅ΡΡΡ Π²ΡΠ²ΠΎΠ΄ ΠΎ ΡΠΎΠΌ, ΡΡΠΎ Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ Π½Π°ΡΠΊΠΈ ΠΌΠ΅Π½ΡΠ»ΠΈΡΡ ΡΡΠ»ΠΎΠ²ΠΈΡ ΠΏΠΎΠ²ΡΠΎΡΠ΅Π½ΠΈΠΉ Π½Π°ΡΡΠ½ΡΡ
ΠΎΡΠΊΡΡΡΠΈΠΉ. Π Π°Π·ΠΌΡΠ²Π°Π½ΠΈΠ΅ ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅Π² Π½Π°ΡΡΠ½ΠΎΡΡΠΈ, ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΡ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ Π½Π°ΡΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠΎΠ±ΡΠ΅ΡΡΠ²Π°, ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΠΎΠ»ΠΈ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π° Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π½Π°ΡΠΊΠΈ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°Π»ΠΈ ΡΠΎΠΌΡ, ΡΡΠΎ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½Π°Ρ Π½Π°ΡΠΊΠ° Π²ΡΠ΅ Π±ΠΎΠ»ΡΡΠ΅ Π½Π°Ρ
ΠΎΠ΄ΠΈΡ ΡΠ΅Π±Π΅ ΠΎΠΏΡΠ°Π²Π΄Π°Π½ΠΈΠ΅ ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ Π²Π»Π°ΡΡΠΈ, ΡΠ΅ΡΠ΅Π· Π²Π»Π°ΡΡΡ, Π° Π²Π»Π°ΡΡΡ ΠΎΠΏΡΠ°Π²Π΄ΡΠ²Π°Π΅Ρ Π½Π°ΡΠΊΡ ΠΏΠ΅ΡΠ΅Π΄ ΠΎΠ±ΡΠ΅ΡΡΠ²ΠΎΠΌ ΠΈ Π΄ΠΎΠΌΠΈΠ½ΠΈΡΡΠ΅Ρ Π½Π°Π΄ Π½ΠΈΠΌ ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ Π°ΠΏΠ΅Π»Π»ΡΡΠΈΠΈ ΠΊ Π½Π°ΡΠΊΠ΅
The Novel Human Influenza A(H7N9) Virus Is Naturally Adapted to Efficient Growth in Human Lung Tissue
A novel influenza A virus (IAV) of the H7N9 subtype has been isolated from severely diseased patients with pneumonia and acute respiratory distress syndrome and, apparently, from healthy poultry in March 2013 in Eastern China. We evaluated replication, tropism, and cytokine induction of the A/Anhui/1/2013 (H7N9) virus isolated from a fatal human infection and two low-pathogenic avian H7 subtype viruses in a human lung organ culture system mimicking infection of the lower respiratory tract. The A(H7N9) patient isolate replicated similarly well as a seasonal IAV in explanted human lung tissue, whereas avian H7 subtype viruses propagated poorly. Interestingly, the avian H7 strains provoked a strong antiviral type I interferon (IFN-I) response, whereas the A(H7N9) virus induced only low IFN levels. Nevertheless, all viruses analyzed were detected predominantly in type II pneumocytes, indicating that the A(H7N9) virus does not differ in its cellular tropism from other avian or human influenza viruses. Tissue culture-based studies suggested that the low induction of the IFN-Ξ² promoter correlated with an efficient suppression by the viral NS1 protein. These findings demonstrate that the zoonotic A(H7N9) virus is unusually well adapted to efficient propagation in human alveolar tissue, which most likely contributes to the severity of lower respiratory tract disease seen in many patients
Approaches for high-speed melt pool detection in laser welding applications
In this paper several approaches for the detection of the melt pool circle (i.e. its position and radius) in laser welding applications are described. Instead of indirectly examining the evolution of the melt pool via the radiation of plasma that is generated during the welding process, we use a direct view onto the melt pool that is possible in a narrow wavelength band with a coaxial aligned high speed CMOS imaging sensor. Since visual inspection is often a bottleneck in mass production, we focus on high speed approaches that enable real-time monitoring of the melt pool parameters